油性鱼类摄入与前列腺癌风险及预后关联性的研究进展综述
A Review of Research Progress on the Association between Oily Fish Intake and the Risk and Prognosis of Prostate Cancer
摘要: 前列腺癌是全球男性最常见的恶性肿瘤，其发生发展与环境和生活方式因素密切相关。饮食因素，尤其是富含长链n-3多不饱和脂肪酸的油性鱼类摄入，在癌症预防与治疗中的作用逐渐受到广泛关注。本文旨在系统综述油性鱼类摄入与前列腺癌发病风险、疾病进展及患者生存预后之间关联的流行病学证据，并深入探讨其潜在的生物学机制，如发挥抗炎作用、调节关键细胞信号通路及影响肿瘤微环境等。同时，本文也分析了当前研究存在的争议与局限性，并对未来研究方向进行展望，以期为前列腺癌的膳食预防和辅助治疗策略提供科学依据。
Abstract: Prostate cancer which is one of the most common malignant tumors among men all over the world has its occurrence and development closely related with environmental and lifestyle factors. Dietary factors, especially the intake of fatty fish that are rich in long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs), have been attracting more and more attention because of their potential functions in cancer prevention and treatment. This article intends to carry out a systematic review of the epidemiological evidence related to the associations between the consumption of oily fish and prostate cancer incidence, disease progression, and patient survival outcomes. It also delves into the potential biological “mechanisms” as well, including the anti-inflammatory “effects” as well as the regulation of key cellular signaling pathways and the adjustment of the tumor microenvironment. In addition, this paper analyzes the current controversies and limitations in existing research and offers perspectives on future directions, with the goal of providing a scientific basis for dietary prevention and adjuvant therapeutic strategies for prostate cancer.
文章引用：胡科, 卿菁, 张家模. 油性鱼类摄入与前列腺癌风险及预后关联性的研究进展综述[J]. 临床医学进展, 2026, 16(4): 3324-3332. https://doi.org/10.12677/acm.2026.1641594

参考文献

[1] Ross, J.A., Vissers, J.P.C., Nanda, J., Stewart, G.D., Husi, H., Habib, F.K., et al. (2020) The Influence of Hypoxia on the Prostate Cancer Proteome. Clinical Chemistry and Laboratory Medicine (CCLM), 58, 980-993. [Google Scholar] [CrossRef] [PubMed]
[2] Wilson, K.M. and Mucci, L.A. (2019) Diet and Lifestyle in Prostate Cancer. In: Dehm, S. and Tindall, D., Eds., Prostate Cancer, Springer, 1-27. [Google Scholar] [CrossRef] [PubMed]
[3] Plym, A., Zhang, Y., Stopsack, K.H., Delcoigne, B., Wiklund, F., Haiman, C., et al. (2023) A Healthy Lifestyle in Men at Increased Genetic Risk for Prostate Cancer. European Urology, 83, 343-351. [Google Scholar] [CrossRef] [PubMed]
[4] Allen, R., Liu, V., Chan, J.M., Graff, R.E., Stampfer, M.J., Aronson, W.J., et al. (2026) Effect of Postdiagnosis Diet and Lifestyle on Clinical Outcomes in Prostate Cancer Survivors: A Systematic Review. Journal of Urology, 215, 376-395. [Google Scholar] [CrossRef] 
[5] Langlais, C.S., Graff, R.E., Van Blarigan, E.L., Kenfield, S.A., Neuhaus, J., Tabung, F.K., et al. (2022) Postdiagnostic Inflammatory, Hyperinsulinemic, and Insulin-Resistant Diets and Lifestyles and the Risk of Prostate Cancer Progression and Mortality. Cancer Epidemiology, Biomarkers & Prevention, 31, 1760-1768. [Google Scholar] [CrossRef] [PubMed]
[6] Plym, A., Zhang, Y., Stopsack, K.H., Ugalde-Morales, E., Seibert, T.M., Conti, D.V., et al. (2024) Early Prostate Cancer Deaths among Men with Higher vs Lower Genetic Risk. JAMA Network Open, 7, e2420034. [Google Scholar] [CrossRef] [PubMed]
[7] Babakhanlou, R. and Gowin, K. (2025) The Impact of Diet and Nutrition on Prostate Cancer—Food for Thought? Current Oncology Reports, 27, 278-289. [Google Scholar] [CrossRef] [PubMed]
[8] Huang, J., Liu, D., Li, J., Xu, J., Dong, S. and Zhang, H. (2023) A 12-Gene Panel in Estimating Hormone-Treatment Responses of Castration-Resistant Prostate Cancer Patients Generated Using a Combined Analysis of Bulk and Single-Cell Sequencing Data. Annals of Medicine, 55, Article ID: 2260387. [Google Scholar] [CrossRef] [PubMed]
[9] Liu, V.N., Van Blarigan, E.L., Zhang, L., Graff, R.E., Loeb, S., Langlais, C.S., et al. (2024) Plant-Based Diets and Disease Progression in Men with Prostate Cancer. JAMA Network Open, 7, e249053. [Google Scholar] [CrossRef] [PubMed]
[10] Pernigoni, N., Zagato, E., Calcinotto, A., Troiani, M., Mestre, R.P., Calì, B., et al. (2021) Commensal Bacteria Promote Endocrine Resistance in Prostate Cancer through Androgen Biosynthesis. Science, 374, 216-224. [Google Scholar] [CrossRef] [PubMed]
[11] Fujita, K., Matsushita, M., Banno, E., De Velasco, M.A., Hatano, K., Nonomura, N., et al. (2022) Gut Microbiome and Prostate Cancer. International Journal of Urology, 29, 793-798. [Google Scholar] [CrossRef] [PubMed]
[12] Mughees, M., Kaushal, J.B., Sharma, G., Wajid, S., Batra, S.K. and Siddiqui, J.A. (2022) Chemokines and Cytokines: Axis and Allies in Prostate Cancer Pathogenesis. Seminars in Cancer Biology, 86, 497-512. [Google Scholar] [CrossRef] [PubMed]
[13] Pal, A., Kainat, Bano, N. and Sharma, P.K. (2025) Targeting Epigenetic Effects of Androgen-Androgen Receptor Signaling in Prostate Cancer. Vitamins and Hormones, 129, 143-183. [Google Scholar] [CrossRef] [PubMed]
[14] Wang, A., Van Blarigan, E.L., Cheng, I., Chan, J.M., Wan, P., Park, S., et al. (2025) Race and Ethnicity, Lifestyle, Diet, and Survival in Patients with Prostate Cancer. JAMA Network Open, 8, e2460785. [Google Scholar] [CrossRef] [PubMed]
[15] Unterberger, C.J., Maklakova, V.I., Lazar, M., Arneson, P.D., Mcilwain, S.J., Tsourkas, P.K., et al. (2022) GH Action in Prostate Cancer Cells Promotes Proliferation, Limits Apoptosis, and Regulates Cancer-Related Gene Expression. Endocrinology, 163, bqac031. [Google Scholar] [CrossRef] [PubMed]
[16] Zhang, Y., Stopsack, K.H., Song, M., Mucci, L.A., Liu, B., Penney, K.L., et al. (2024) Healthy Dietary Patterns and Risk of Prostate Cancer in Men at High Genetic Risk. International Journal of Cancer, 155, 71-80. [Google Scholar] [CrossRef] [PubMed]
[17] Wright, J.L., Schenk, J.M., Gulati, R., Beatty, S.J., VanDoren, M., Lin, D.W., et al. (2024) The Prostate Cancer Active Lifestyle Study (PALS): A Randomized Controlled Trial of Diet and Exercise in Overweight and Obese Men on Active Surveillance. Cancer, 130, 2108-2119. [Google Scholar] [CrossRef] [PubMed]
[18] Bergengren, O., Enblad, A.P., Garmo, H., Bratt, O., Holmberg, L., Johansson, E., et al. (2020) Changes in Lifestyle among Prostate Cancer Survivors: A Nationwide Population‐Based Study. Psycho-Oncology, 29, 1713-1719. [Google Scholar] [CrossRef] [PubMed]
[19] Hybel, T.E., Dietrichs, D., Sahana, J., Corydon, T.J., Nassef, M.Z., Wehland, M., et al. (2020) Simulated Microgravity Influences VEGF, MAPK, and PAM Signaling in Prostate Cancer Cells. International Journal of Molecular Sciences, 21, Article 1263. [Google Scholar] [CrossRef] [PubMed]
[20] Pisano, C., Tucci, M., Di Stefano, R.F., Turco, F., Scagliotti, G.V., Di Maio, M., et al. (2021) Interactions between Androgen Receptor Signaling and Other Molecular Pathways in Prostate Cancer Progression: Current and Future Clinical Implications. Critical Reviews in Oncology/Hematology, 157, Article ID: 103185. [Google Scholar] [CrossRef] [PubMed]
[21] Sánchez, P., Castro, B., Martínez-Rodríguez, S., Ríos-Pelegrina, R., del Moral, R.G., Torres, J.M., et al. (2022) Impact of Chronic Exposure of Rats to Bisphenol a from Perinatal Period to Adulthood on Intraprostatic Levels of 5α-Reductase Isozymes, Aromatase, and Genes Implicated in Prostate Cancer Development. Environmental Research, 212, Article ID: 113142. [Google Scholar] [CrossRef] [PubMed]
[22] Shi, X., Zhang, Y., Shi, Y., Zhang, Q., Duan, H., Liu, J., et al. (2023) Analysis of the Alleviating Effect of Modified Huangqi Chifeng Decoction on Rats with Focal Segmental Glomerulosclerosis Based on Gut Microbiota and Fecal Metabolomics. Journal of Applied Microbiology, 134, lxad205. [Google Scholar] [CrossRef] [PubMed]

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