慢性胰腺炎的切除引流术的临床进展:从Beger手术到Berne手术
Clinical Progression of Resection and Drainage Surgery for Chronic Pancreatitis: From Beger Surgery to Berne Surgery
DOI: 10.12677/acm.2026.1641597, PDF,    科研立项经费支持
作者: 唐子威, 王槐志*:重庆医科大学,重庆;重庆市人民医院肝胆胰腺外科,重庆
关键词: 慢性胰腺炎保留十二指肠的胰头切除术胰腺外科Chronic Pancreatitis Duodenum-Preserving Pancreatic Head Resection Pancreatic Surgery Department
摘要: 胰头切除术(Pancreatic Head Resection, PHR)是一种以保留功能器官为特点的胰腺外科技术,尤其适用于慢性胰腺炎、胰腺良性肿瘤的外科干预。具有组织创伤小、出血少、住院时间短、保留更多胰腺组织等明显优势。DPPHR现已成为治疗胰头良性病变的重要方式,其中主要包括三种代表性术式:保留十二指肠的胰头切除术(Duodenum-Preserving Pancreatic Head Resection, Beger Procedure)、局限性胰头切除加胰管纵切空肠吻合术(Partial Pancreatic Head and Side-to-Side Pancreaticoduct-Jejunal Anastomosis, Frey Procedure)以及保留十二指肠次全胰头切除术(Pylorus-Preserving Subtotal Pancreatic Head Resection, Berne Procedure)。对于胰腺良性病变,传统胰十二指肠切除术需要整体切除胰头部(包括胰头和钩突)、全部十二指肠、胆囊、胆总管下端、远端胃、近端空肠(约15~20 cm),该术式因切除范围广泛,严重破坏了消化系统的完整性和功能性,影响了患者术后的生活质量。
Abstract: Pancreatic head resection (PHR) is a pancreatic surgical technique characterized by the preservation of functional organs. It is particularly indicated for chronic pancreatitis and benign pancreatic tumors, offering notable advantages such as reduced tissue trauma, minimal blood loss, shorter hospital stay, and greater preservation of pancreatic parenchyma. DPPHR has now become an important surgical approach for benign lesions of the pancreatic head, with three representative procedures being predominantly utilized: the duodenum-preserving pancreatic head resection (Beger procedure), partial pancreatic head resection with longitudinal pancreatic duct-jejunal anastomosis (Frey procedure), and the pylorus-preserving subtotal pancreatic head resection (Berne procedure). For benign pancreatic lesions, the conventional pancreaticoduodenectomy involves en bloc resection of the pancreatic head (including the head and uncinate process), the entire duodenum, the gallbladder, the distal common bile duct, the distal stomach, and a proximal segment of the jejunum (approximately 15~20 cm). This procedure, characterized by its extensive resection, substantially disrupts the integrity and function of the digestive system, thereby impairing the patient’s postoperative quality of life.
文章引用:唐子威, 王槐志. 慢性胰腺炎的切除引流术的临床进展:从Beger手术到Berne手术[J]. 临床医学进展, 2026, 16(4): 3348-3356. https://doi.org/10.12677/acm.2026.1641597

参考文献

[1] Beyer, G., Habtezion, A., Werner, J., Lerch, M.M. and Mayerle, J. (2020) Chronic Pancreatitis. The Lancet, 396, 499-512. [Google Scholar] [CrossRef] [PubMed]
[2] Mansbach, C.M. (2004) Malabsorption. In: Johnson, L.R., Ed., Encyclopedia of Gastroenterology, Elsevier, 597-603. [Google Scholar] [CrossRef
[3] Li, J., Wen, L. and Yang, A. (2026) Mechanistic Insights into Pancreatic Duct Pressure: From Basic Physiology to Translational Implications. Current Opinion in Gastroenterology, 42, 100-105. [Google Scholar] [CrossRef
[4] Di Sebastiano, P., di Mola, F.F., Bockman, D.E., Friess, H. and Büchler, M.W. (2003) Chronic Pancreatitis: The Perspective of Pain Generation by Neuroimmune Interaction. Gut, 52, 907-911. [Google Scholar] [CrossRef] [PubMed]
[5] Demir, I.E., Friess, H. and Ceyhan, G.O. (2015) Neural Plasticity in Pancreatitis and Pancreatic Cancer. Nature Reviews Gastroenterology & Hepatology, 12, 649-659. [Google Scholar] [CrossRef] [PubMed]
[6] 杨永君, 向吉锋, 王槐志. 保留十二指肠、胆总管、Oddi’s括约肌的胰头整块全切除术(王氏手术)的手术要点及应用[J]. 中国普外基础与临床杂志, 2025, 32(2): 143-147.
[7] Kleeff, J., Klose, J. and Ronellenfitsch, U. (2025) Combined Procedures (Open vs. Mis). In: Ceppa, E.P., El-Hayek, K.M., Hogg, M.E. and Pecorelli, N., Eds., The SAGES Manual of Evolving Techniques in Pancreatic Surgery, Springer, 141-155. [Google Scholar] [CrossRef
[8] Lark, M.E., Maatman, T.K. and Zyromski, N.J. (2025) Duodenal-Preserving Pancreatic Head Resection: A Pictorial Essay. Journal of Gastrointestinal Surgery, 29, Article ID: 102044. [Google Scholar] [CrossRef] [PubMed]
[9] Beger, H.G., Kunz, R. and Poch, B. (2004) The Beger Procedure—Duodenum-Preserving Pancreatic Head Resection. Journal of Gastrointestinal Surgery, 8, 1090-1097. [Google Scholar] [CrossRef] [PubMed]
[10] Beger, H.G., Mayer, B. and Poch, B. (2023) Duodenum-Preserving Pancreatic Head Resection for Benign and Premalignant Tumors—A Systematic Review and Meta-Analysis of Surgery-Associated Morbidity. Journal of Gastrointestinal Surgery, 27, 2611-2627. [Google Scholar] [CrossRef] [PubMed]
[11] Müller, M.W., Friess, H., Martin, D.J., Hinz, U., Dahmen, R. and Büchler, M.W. (2008) Long-Term Follow-Up of a Randomized Clinical Trial Comparing Beger with Pylorus-Preserving Whipple Procedure for Chronic Pancreatitis. Journal of British Surgery, 95, 350-356. [Google Scholar] [CrossRef] [PubMed]
[12] Ray, S., Basu, C., Dhali, A. and Dhali, G.K. (2022) Frey Procedure for Chronic Pancreatitis: A Narrative Review. Annals of Medicine & Surgery, 80, Article ID: 104229. [Google Scholar] [CrossRef] [PubMed]
[13] Frey, C.F. and Smith, G.J. (1987) Description and Rationale of a New Operation for Chronic Pancreatitis. Pancreas, 2, 701-707. [Google Scholar] [CrossRef] [PubMed]
[14] Keck, T., Wellner, U.F., Riediger, H., Adam, U., Sick, O., Hopt, U.T., et al. (2010) Long-Term Outcome after 92 Duodenum-Preserving Pancreatic Head Resections for Chronic Pancreatitis: Comparison of Beger and Frey Procedures. Journal of Gastrointestinal Surgery, 14, 549-556. [Google Scholar] [CrossRef] [PubMed]
[15] Strobel, O., Büchler, M.W. and Werner, J. (2009) Duodenumerhaltende Pankreaskopfresektion: Technik nach Beger, Technik nach Frey und Berner Modifikation [Duodenum-Preserving Pancreatic Head Resection: Technique According to Beger, Technique According to Frey and Berne Modifications]. Der Chirurg, 80, 22-27. [Google Scholar] [CrossRef] [PubMed]
[16] Kelemen, D., Deák, R., Ferencz, S., Farkas, N. and Vereczkei, A. (2024) Comparative Study of Different Types of Pancreatic Head Resection for Chronic Pancreatitis. Indian Journal of Surgery, 86, 130-136. [Google Scholar] [CrossRef
[17] Klaiber, U., Alldinger, I., Probst, P., Bruckner, T., Contin, P., Köninger, J., et al. (2016) Duodenum-Preserving Pancreatic Head Resection: 10-Year Follow-Up of a Randomized Controlled Trial Comparing the Beger Procedure with the Berne Modification. Surgery, 160, 127-135. [Google Scholar] [CrossRef] [PubMed]
[18] Mou, Y., Song, Y., Chen, H., Wang, X., Huang, W., Liu, X., et al. (2022) Which Surgeries Are the Best Choice for Chronic Pancreatitis: A Network Meta-Analysis of Randomized Controlled Trials. Frontiers in Surgery, 8, Article 798867. [Google Scholar] [CrossRef] [PubMed]
[19] 刘颂, 卢杏生. 保留十二指肠的胰头切除术的临床及微创应用进展[J]. 中国普外基础与临床杂志, 2023, 30(11): 1395-1401.
[20] Cai, H., Cai, Y., Wang, X. and Peng, B. (2020) Laparoscopic Beger Procedure for the Treatment of Chronic Pancreatitis: A Single-Centre First Experience. BMC Surgery, 20, Article No. 84. [Google Scholar] [CrossRef] [PubMed]
[21] Li, Y., Zong, K., Li, M., Liu, Y., Wu, Z. and Zhou, B. (2024) Video-based Indocyanine Green Fluorescence Applied to Robotic Duodenum-Preserving Pancreatic Head Resection. Annals of Surgical Oncology, 31, 2654-2655. [Google Scholar] [CrossRef] [PubMed]
[22] Beger, H.G., Mayer, B. and Poch, B. (2025) Duodenum-Preserving Pancreatic Head Resection in 1063 Patients for Benign, Premalignant Cystic, and Neuroendocrine Neoplasms—Short-Term Surgical Outcomes and Risk of Recurrence—Results of a Systematic Review. HPB, 27, 1489-1502. [Google Scholar] [CrossRef