血清β-hCG在辅助生殖早期妊娠结局预测中的研究进展与临床应用
Research Progress and Clinical Application of Serum β-hCG in Predicting Early Pregnancy Outcomes in Assisted Reproduction
DOI: 10.12677/acm.2026.1641598, PDF,   
作者: 彭娇霞, 李维宏*：重庆医科大学附属第一医院生殖医学中心，重庆
关键词: ART；β-hCG；妊娠结局预测；截断值；联合预测模型；ART； β-hCG； Pregnancy Outcome Prediction； Cutoff Value； Combined Prediction Model
摘要: 早期妊娠结局预测是辅助生殖技术(assisted reproductive technology, ART)中的核心环节。血清β-人绒毛膜促性腺激素(β-human chorionic gonadotropin, β-hCG)作为胚胎着床后最早可检测的生物标志物，其水平及增长趋势与妊娠结局密切相关，但不同研究提出的预测参数和cutoff值仍存在一定差异，因此系统梳理相关研究具有一定的临床意义。本文旨在系统性地梳理β-hCG在ART治疗后早期妊娠结局预测中的价值及其相应的关键参数，重点分析不同检测时间点的预测效能、关键参数(cutoff值、增长倍数)的临床意义，探讨多种变量联合预测妊娠结局的模型构建及其在临床上的应用，以期为患者提供早期的妊娠咨询、缓解其焦虑紧张情绪，也为临床医生提供相关理论参考依据。
Abstract: Early pregnancy outcome prediction is a critical component of assisted reproductive technology (ART). Serum β-human chorionic gonadotropin (β-hCG), as the earliest detectable biomarker following embryo implantation, exhibits levels and growth patterns closely associated with pregnancy outcomes. However, discrepancies persist among studies regarding predictive parameters and cutoff values, underscoring the clinical significance of systematically reviewing relevant research. This article aims to comprehensively summarize the value of β-hCG in predicting early pregnancy outcomes after ART treatment and its corresponding key parameters, with a focus on analyzing the predictive efficacy at different detection time points and the clinical implications of critical parameters (cutoff values, doubling time). It also explores the construction of multi-variable combined prediction models for pregnancy outcomes and their clinical application, with the goal of providing early pregnancy counseling to alleviate patient anxiety and offering theoretical reference for clinicians.
文章引用：彭娇霞, 李维宏. 血清β-hCG在辅助生殖早期妊娠结局预测中的研究进展与临床应用[J]. 临床医学进展, 2026, 16(4): 3357-3365. https://doi.org/10.12677/acm.2026.1641598

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