子宫内膜癌中IL-1β、IL-6及TNF-α的研究 现状综述
A Review of Research on IL-1β, IL-6, and TNF-α in Endometrial Cancer
DOI: 10.12677/acm.2026.1641614, PDF,   
作者: 陈 艺：重庆医科大学第一临床医学院，重庆；王 辉*：重庆医科大学附属第一医院妇科，重庆
关键词: 细胞因子；子宫内膜癌；炎症；Cytokine； Endometrial Cancer； Inflammation
摘要: 子宫内膜癌作为女性生殖系统常见恶性肿瘤，其发病与慢性炎症密切相关。本文综述了IL-1β、IL-6及TNF-α三种促炎细胞因子在子宫内膜癌中的作用机制、临床意义及应用前景。现有研究表明，这三种细胞因子通过参与免疫逃逸、调控肿瘤细胞增殖、侵袭与转移等过程，在肿瘤发生发展中发挥关键作用，并具备成为早期筛查和预后评估无创标志物的潜力。
Abstract: Endometrial cancer is a common malignancy of the female reproductive tract, and its development is closely linked to chronic inflammation. This review examines the mechanisms, clinical relevance, and potential applications of three pro-inflammatory cytokines—IL-1β, IL-6, and TNF-α, in endometrial cancer. Current evidence indicates that these cytokines contribute to tumor initiation and progression by promoting immune escape and regulating tumor cell proliferation, invasion, and metastasis. In addition, they show promise as noninvasive biomarkers for early detection and prognostic evaluation.
文章引用：陈艺, 王辉. 子宫内膜癌中IL-1β、IL-6及TNF-α的研究 现状综述[J]. 临床医学进展, 2026, 16(4): 3502-3507. https://doi.org/10.12677/acm.2026.1641614

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