基于中西医临床病症特点的子宫内膜癌动物模型

Animal Models of Endometrial Cancer Based on the Clinical Characteristics of the Disease in Both Traditional Chinese and Western Medicine

摘要: 子宫内膜癌(Endometrial Cancer, EC)是源于子宫内膜的恶性肿瘤，目前临床尚缺乏有效的治疗措施。动物模型在临床新药的研究及治疗进展中具有不可替代的作用。文章通过查阅知网、PubMed及相关文献，总结了EC主要造模方法，对造模方法原理、优缺点、与中西医临床吻合度进行评价。发现目前EC造模动物以小鼠为主，最常见的是裸鼠；造模方法包括移植与非移植模型，其中皮下移植模型是EC造模最常见的造模方法；转基因模型与西医临床吻合度最高，大多造模方法多将西医作为评价指标，缺少中医证候描述，中医吻合度普遍偏低，在模型发展仍需进一步完善。未来研究可探索动物行为学与中医证候相关联，建立更客观的动物证候模型评价体系，纳入动态评价标准，观察模型在疾病不同阶段的证候演变。

Abstract: Endometrial cancer (EC) is a malignant tumor originating from the endometrial lining, and effective clinical treatment measures are currently lacking. The role of animal models in the research and development of new clinical drugs and therapeutic advances cannot be overlooked. By reviewing CNKI, PubMed, and relevant literature, this study summarizes the primary methods for establishing EC models and evaluates their underlying principles, advantages, and disadvantages, as well as their alignment with clinical practices in both Western and traditional Chinese medicine. It was found that mice are the primary animals used for EC modeling, with nude mice being the most common. Modeling methods include both transplant and non-transplant models, among which the subcutaneous transplantation model is the most commonly used. Transgenic models exhibit the highest degree of correlation with Western medical clinical findings. Most modeling methods use Western medical indicators for evaluation, lacking descriptions of Traditional Chinese Medicine (TCM) syndromes. The concordance with TCM is generally low, indicating that further refinement is needed in model development. Future research could explore the correlation between animal behavior and TCM syndromes to establish a more objective evaluation system for animal syndrome models, incorporating dynamic evaluation criteria to observe the evolution of syndromes at different stages of the disease.