针灸调节线粒体治疗缺血性脑卒中的实验研究进展
Experimental Research Progress on Acupuncture Regulating Mitochondria in the Treatment of Ischemic Stroke
DOI: 10.12677/tcm.2026.154233, PDF,   
作者: 路兆麟：黑龙江中医药大学研究生院，黑龙江 哈尔滨；尹洪娜*：黑龙江中医药大学附属第二医院针灸科，黑龙江 哈尔滨
关键词: 中医；线粒体；分子机制；综述；缺血性卒中；Traditional Chinese Medicine； Mitochondria； Molecular Mechanism； Review； Ischemic Stroke
摘要: 缺血性卒中因其高患病率、复杂发病机制及治疗困难性，一直是科学研究的重点领域。线粒体在细胞能量稳态中起重要作用，并参与缺血性卒中后的神经元死亡过程。因此，维持线粒体功能对缺血性卒中患者的神经元存活及神经功能改善至关重要，线粒体成为脑卒中研究中的关键治疗靶点。传统中医凭借高效性、低成本及高安全性优势，在缺血性卒中防治领域具有显著优势。大量研究从调控线粒体结构与功能的角度探讨了中医防治缺血性卒中的作用。本综述重点阐述线粒体参与缺血性卒中的分子机制，并总结当前通过调节线粒体实现中医防治缺血性卒中的研究进展，旨在为通过线粒体调控机制开展中医防治缺血性卒中提供新视角与启示。
Abstract: Ischemic stroke has long been a key area of scientific research due to its high prevalence, complex pathogenesis, and therapeutic challenges. Mitochondria play a vital role in cellular energy homeostasis and participate in the process of neuronal death following ischemic stroke. Therefore, maintaining mitochondrial function is crucial for neuronal survival and neurological function recovery in patients with ischemic stroke, making mitochondria a critical therapeutic target in stroke research. Traditional Chinese Medicine (TCM) has prominent advantages in the prevention and treatment of ischemic stroke owing to its high efficacy, low cost, and favorable safety profile. Numerous studies have investigated the effects of TCM on ischemic stroke by regulating mitochondrial structure and function. This review focuses on the molecular mechanisms by which mitochondria are involved in ischemic stroke and summarizes the current research progress of TCM in preventing and treating ischemic stroke through mitochondrial modulation. It aims to provide new perspectives and insights for TCM research targeting mitochondria in the management of ischemic stroke.
文章引用：路兆麟, 尹洪娜. 针灸调节线粒体治疗缺血性脑卒中的实验研究进展[J]. 中医学, 2026, 15(4): 468-477. https://doi.org/10.12677/tcm.2026.154233

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