中蒙药干预大鼠癫痫的作用及其药理机制综述
A Review of the Effect of Chinese and Mongolian Medicine on Epilepsy in Rats and Its Pharmacological Mechanism
DOI: 10.12677/acm.2026.1641622, PDF,    科研立项经费支持
作者: 郝 丽, 陈柏谕, 付俊鲜, 李天霞, 乔治东, 贾月欣, 潘 浩, 杨涌禄, 贾凯茹, 赵 璐, 李珮荣, 昝曼杰, 杨光路*：内蒙古医科大学附属医院儿科，内蒙古 呼和浩特
关键词: 中医；中药；蒙医药；癫痫；大鼠；Traditional Chinese Medicine； Chinese Herbal Medicine； Mongolian Medicine； Epilepsy； Rat
摘要: 目的：癫痫是一种复杂的、以持久性惊厥发作倾向为核心特征的慢性脑部疾病，可表现为肌肉痉挛、短暂认知障碍和情感症状的一组脑功能障碍。目前研究认为其发病机制主要为兴奋性和抑制性神经传递的失调，导致不受控制的神经元放电。在临床实践中，多种中药及蒙药展现出显著的抗癫痫作用，人们对其抗癫痫治疗的研究也更加深入。本文旨在基于现有研究，系统综述了多种中药及蒙药对大鼠癫痫的干预作用及其药理机制，为中蒙药抗癫痫的深入研究与临床应用提供理论参考。方法：以“癫痫”、“中药”或“草药”、“蒙医药”等为关键词，在中国知网、Pubmed等数据库中分别检索中文、英文相关文献共41篇，收集相关公开发布的研究成果作为本综述的分析依据。结论：中药及蒙药治疗癫痫具有多靶点、多通路、多途径的特点，且副作用相对较小，同时，其联合西药治疗可协同增效，对共病有更好的改善效果，在癫痫的治疗中展现出独特的疗效。
Abstract: Objective: Epilepsy is a complex neurological disorder characterized by seizures, muscle spasms, transient cognitive impairment, and emotional symptoms. Etiology usually involves dysregulation of excitatory and inhibitory neurotransmission, leading to uncontrolled neuronal firing. In clinical practice, various traditional Chinese medicines and Mongolian medicines have shown significant antiepileptic effects, and research on their antiepileptic treatment has become more in-depth. This article aims to systematically review the intervention effects and pharmacological mechanisms of various traditional Chinese medicines and Mongolian medicines on epilepsy in rats based on existing research, providing theoretical references for the in-depth study and clinical application of Chinese and Mongolian medicines in anti-epilepsy. Method: Using keywords such as “epilepsy”, “traditional Chinese medicine”, “herbal medicine”, “Mongolian medicine”, etc., a total of 41 Chinese and English related literature were retrieved from databases such as CNKI and PubMed. Relevant publicly released research results were collected as the analysis basis for this review. Conclusion: Traditional Chinese medicine and Mongolian medicine in the treatment of epilepsy have the characteristics of multi-target, multi-pathway and multi-channel, and the side effects are relatively small. Combined with western medicine, it can synergize and improve the comorbidity, showing a unique curative effect in the treatment of epilepsy.
文章引用：郝丽, 陈柏谕, 付俊鲜, 李天霞, 乔治东, 贾月欣, 潘浩, 杨涌禄, 贾凯茹, 赵璐, 李珮荣, 昝曼杰, 杨光路. 中蒙药干预大鼠癫痫的作用及其药理机制综述[J]. 临床医学进展, 2026, 16(4): 3582-3590. https://doi.org/10.12677/acm.2026.1641622

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