生物打印技术在皮肤组织工程的应用研究进展
Research Progress of Bioprinting Technology in Skin Tissue Engineering
DOI: 10.12677/ms.2026.164084, PDF,   
作者: 吴 聪, 李泽宇, 李润泽*, 王光硕：河北工程大学材料科学与工程学院，河北 邯郸
关键词: 生物打印；皮肤组织工程；生物墨水；研究进展；Bioprinting； Skin Tissue Engineering； Biological Ink； Research Progress
摘要: 皮肤是人体最大的屏障器官，其缺损不仅影响外观，更会引发感染等一系列临床问题。生物打印技术作为组织工程领域的新型组织工程手段，能够依据数字模型精确调控种子细胞与生物材料在三维空间内的分布，为实现个体化、结构仿生的皮肤组织构建提供了全新策略。本文系统综述了用于皮肤组织工程的生物墨水的研发进展，并比较了不同生物打印技术的特性与适用性。同时，深入探讨了该技术走向临床所面临的核心挑战，并针对性地提出了可能的解决方案，为生物打印技术在皮肤再生领域的深入发展与临床转化提供理论参考和实践思路。
Abstract: The skin, being the body’s primary barrier organ, poses significant clinical challenges beyond cosmetic concerns when injured, primarily due to risks of infection. Bioprinting has emerged as a novel tissue engineering approach in tissue engineering, allowing for the precise, digital model-driven deposition of cells and biomaterials to create patient-specific, anatomically relevant skin constructs. This review comprehensively investigates the development of novel bioinks tailored for skin bioprinting and critically evaluates the capabilities and limitations of prevailing bioprinting techniques. Promising strategies to address these hurdles are also outlined, with the goal of informing future research directions and facilitating the translation of bioprinting technologies into effective clinical therapies for skin repair.
文章引用：吴聪, 李泽宇, 李润泽, 王光硕. 生物打印技术在皮肤组织工程的应用研究进展[J]. 材料科学, 2026, 16(4): 180-186. https://doi.org/10.12677/ms.2026.164084

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