中性粒细胞胞外诱捕网与特发性膜性肾病相关性研究
Correlation between Neutrophil Extracellular Traps and Idiopathic Membranous Nephropathy
摘要: 特发性膜性肾病(IMN)是一种自身免疫性肾小球疾病，是慢性肾脏病(CKD)的常见病因之一。其发病机制主要由循环中的自身抗体针对足细胞抗原引起，主要包括M型磷脂酶A2受体(PLA2R)和含血栓质谱的7A (THSD7A)，也与环境刺激、遗传因素、异常免疫介导的炎症反应密切相关。中性粒细胞胞外诱捕网作为活化的中性粒细胞释放的独特网状结构，在自身免疫疾病中具有潜在毒性，可形成促炎循环、加重内皮损伤、促进肾纤维化及血栓形成等不良反应。本综述侧重探讨NETs与IMN在炎症免疫反应之间的潜在关联，探讨其作为潜在生物标志物和治疗靶点的可能性。
Abstract: Idiopathic membranous nephropathy (IMN) is an autoimmune glomerular disease and one of the common causes of chronic kidney disease (CKD). Its pathogenesis is primarily driven by circulating autoantibodies targeting podocyte antigens, mainly the M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), and is also closely associated with environmental triggers, genetic factors, and aberrant immune-mediated inflammatory responses. Neutrophil extracellular traps (NETs), unique web-like structures released by activated neutrophils, exhibit potential toxicity in autoimmune diseases and can promote pro-inflammatory cycles, exacerbate endothelial injury, and contribute to renal fibrosis and thrombosis. This review focuses on the potential association between NETs and IMN in the context of inflammatory and immune responses, and explores their potential as biomarkers and therapeutic targets.
文章引用：郭嘉钰, 黄兰. 中性粒细胞胞外诱捕网与特发性膜性肾病相关性研究[J]. 临床个性化医学, 2026, 5(2): 622-628. https://doi.org/10.12677/jcpm.2026.52164

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