铁代谢紊乱对肾移植术后并发症的影响
Impact of Iron Metabolism Disorders on Post-Renal Transplantation Complications
DOI: 10.12677/jcpm.2026.52166, PDF,   
作者: 刘晓玉, 刘 玲*：重庆医科大学附属第二医院泌尿肾病中心，重庆
关键词: 铁过载；铁缺乏；肾移植；并发症；Iron Overload； Iron Deficiency； Kidney Transplantation； Complications
摘要: 铁稳态失衡是肾移植受者术后面临的常见问题。铁作为细胞能量代谢与免疫防御网络的关键微量元素，其作用具有“双刃剑”效应。铁缺乏或过载均会对移植物功能及受者远期预后产生影响。本综述系统梳理了铁的生理调控通路，并探讨其在术后贫血、认知功能障碍、移植后糖尿病及感染等并发症中的差异性作用机制。在此基础上，结合现有临床研究证据，分析不同铁代谢状态与移植结局之间的关联及当前研究的局限性，旨在为肾移植受者的长程代谢管理提供更深层次的理论依据。
Abstract: Dysregulation of iron homeostasis is a common complication following kidney transplantation. As a crucial trace element essential for cellular energy metabolism and the immune defense network, iron exerts a “double-edged sword” effect, wherein both iron deficiency and overload can significantly impact graft function and the long-term prognosis of recipients. This review systematically outlines the physiological regulatory pathways of iron and explores its differential mechanistic roles in postoperative complications, including anemia, cognitive dysfunction, post-transplantation diabetes mellitus (PTDM), and infections. Furthermore, by integrating current clinical evidence, we analyze the associations between varying iron metabolic states and transplant outcomes, as well as the limitations of existing research. Ultimately, this review aims to provide a profound theoretical foundation for the long-term metabolic management of kidney transplant recipients.
文章引用：刘晓玉, 刘玲. 铁代谢紊乱对肾移植术后并发症的影响[J]. 临床个性化医学, 2026, 5(2): 637-644. https://doi.org/10.12677/jcpm.2026.52166

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