铁死亡和焦亡:与三种神经退行性疾病的关联
Ferroptosis and Pyroptosis: Association with Three Types of Neurodegenerative Diseases
DOI: 10.12677/acm.2026.1641658, PDF,   
作者: 刘睿瑶:扬州大学医学院,江苏 扬州;孔晴晴, 付雨露, 迟文瑄, 刘 毅:徐州医科大学,江苏省新药研究与临床药学重点实验室,江苏 徐州;高 巨*:扬州大学医学院,江苏 扬州;扬州大学附属苏北人民医院麻醉科,江苏 扬州
关键词: 铁死亡焦亡神经退行性疾病Ferroptosis Pyroptosis Neurodegenerative Disease
摘要: 铁死亡(ferroptosis)和焦亡(pyroptosis)这两种新型细胞死亡模式因其在多种疾病发展中的重要作用而备受关注。铁死亡是一种铁依赖性、非凋亡性细胞死亡形式,其特征为细胞内活性氧(ROS)的积累。焦亡是由炎症驱动的程序性细胞死亡类型,其特征为大量炎症介质的释放。神经退行性疾病(NDDs)表现为神经元功能受损,某些情况下甚至出现神经元死亡。铁死亡和焦亡可加剧神经退行性疾病的起始和进展。本综述旨在探讨铁死亡和焦亡的生物学过程,为三种常见神经退行性疾病的治疗和预防提供新视角。
Abstract: Two novel modes of cell death, ferroptosis and pyroptosis, have attracted a lot of interest recently since their important roles in the development of different diseases. An iron-dependent, non-apoptotic form of cell death, ferroptosis is typified by the accumulation of intracellular reactive oxygen species (ROS). Pyroptosis is a type of programmed cell death driven by inflammation marked by the release of large amounts of inflammatory mediators. A class of neurological diseases known as neurodegenerative diseases (NDDs) consists of compromised neuronal function and in some cases, neuronal death. Ferroptosis and pyroptosis can aggravate the beginning and spread of NDDs. The objective of this review is to provide novel perspectives on the treatment and prevention of three prevalent NDDs. The review investigates the processes of ferroptosis and pyroptosis and their respective consequences.
文章引用:刘睿瑶, 孔晴晴, 付雨露, 迟文瑄, 刘毅, 高巨. 铁死亡和焦亡:与三种神经退行性疾病的关联[J]. 临床医学进展, 2026, 16(4): 3890-3905. https://doi.org/10.12677/acm.2026.1641658

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