ECMO支持期间短期低剂量输注致丙泊酚输注综合征一例并文献复习
Propofol Infusion Syndrome Induced by Short-Term Low-Dose Infusion in a Patient during ECMO Support: A Case Report and Literature Review
摘要: 丙泊酚相关输注综合征(PRIS)是一种罕见并发症，通常与大剂量或长期输注丙泊酚相关。本文报告了一例暴发性心肌炎患者在接受静脉–动脉体外膜氧合(VA-ECMO)治疗期间，使用低剂量(0.5~1.25 mg/(kg·h))丙泊酚进行短期(32小时)镇静后诱发PRIS的病例。丙泊酚镇静的VA-ECMO体外循环掩盖患者血流动力学变化，干扰PRIS临床症状的鉴别诊断，极易发生误诊或漏诊。通过检索PubMed和Embase数据库，尚无ECMO运行期间PRIS的报道。
Abstract: Propofol-related infusion syndrome (PRIS) is a rare complication of propofol, classically linked to high-dose or prolonged administration. We report a case of PRIS in a patient with fulminant myocarditis receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO), which developed PRIS after short-term (32-hour) period with a low-dose propofol sedation [0.5~1.25 mg/(kg·h)]. Mechanical circulatory support may mask the fact of hemodynamic instability and confound the differential diagnosis of PRIS-related clinical manifestations. A comprehensive search of PubMed and Embase databases identified no previously confirmed cases of PRIS reported during VA-ECMO support.
文章引用：王思卿, 刘莹, 赵国立, 邢金燕, 苑志勇. ECMO支持期间短期低剂量输注致丙泊酚输注综合征一例并文献复习[J]. 临床医学进展, 2026, 16(4): 3968-3976. https://doi.org/10.12677/acm.2026.1641665

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