CT-FFR及FAI在冠心病中的应用进展
Application Progress of CT-FFR and FAI in Coronary Heart Disease
DOI: 10.12677/acm.2026.1641677, PDF,   
作者: 刘葑菁, 闫 文, 陈 博：延安大学医学院，陕西 延安；李 飞*：延安大学附属医院心血管内科三病区，陕西 延安
关键词: CT血流储备分数；脂肪衰减指数；冠心病；CT-FFR； FAI； Coronary Heart Disease
摘要: 冠心病是(CHD)临床上最常见的心血管疾病，其发病率仍不断上升。传统冠状动脉CT血管成像(CCTA)在评估冠状动脉狭窄方面具有较高的灵敏度与阴性预测价值，但无法反映血流动力学变化。CT血流储备分数(CT-FFR)可通过模拟冠脉血流动力学，实现“一站式”无创评估，区分解剖狭窄与功能缺血，指导精准干预，避免过度治疗。冠状动脉周围脂肪衰减指数(FAI)作为新型生物标志物，可评估血管炎症状态、识别易损斑块和高危血管段，用于疗效监测和长期心脏事件风险预测。本文对CT-FFR及FAI在冠心病中的应用进展进行综述。
Abstract: Coronary heart disease (CHD) remains the most common clinical cardiovascular disease, with its incidence continuing to rise. Traditional coronary computed tomography angiography (CCTA) demonstrates high sensitivity and negative predictive value in assessing coronary stenosis but fails to reflect hemodynamic changes. Computed tomography-derived fractional flow reserve (CT-FFR) enables a “one-stop” noninvasive evaluation by simulating coronary hemodynamics, distinguishing anatomical stenosis from functional ischemia, thus guiding precise intervention and avoiding overtreatment. The perivascular fat attenuation index (FAI), as a novel biomarker, can assess vascular inflammatory status, identify vulnerable plaques and high-risk vessel segments, and be utilized for therapeutic monitoring and long-term cardiac event risk prediction. This article reviews the application progress of CT-FFR and FAI in coronary heart disease.
文章引用：刘葑菁, 闫文, 陈博, 李飞. CT-FFR及FAI在冠心病中的应用进展[J]. 临床医学进展, 2026, 16(4): 4095-4102. https://doi.org/10.12677/acm.2026.1641677

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