PDMS微流控芯片对 小分子药物吸附的机制、 测定与矫正策略
Absorption of Small-Molecule Drugs in PDMS-Based Organ-on-a-Chip Systems: Mechanisms, Characterization Methods, and Correction Strategies
摘要: 聚二甲基硅氧烷(polydimethylsiloxane, PDMS)因具有良好的光学透明性、气体通透性和加工便利性，被广泛应用于微流控器官芯片系统。然而，PDMS对小分子药物，尤其是疏水性化合物，存在明显的吸附与吸收行为，可导致芯片内药物实际暴露浓度下降，从而影响药物筛选、毒性评价及药代动力学等研究结果的准确性。本文综述了PDMS对小分子药物吸附行为的研究进展，总结其吸附机制及影响因素，并介绍常用的测量与表征方法。同时归纳了降低PDMS吸附影响的工程策略及基于数学模型的浓度矫正方法，以期为器官芯片药物研究中PDMS吸附问题的评估与校正提供参考。
Abstract: Polydimethylsiloxane (PDMS) is widely used in microfluidic organ-on-a-chip systems because of its excellent optical transparency, gas permeability, and ease of fabrication. However, PDMS exhibits significant adsorption and absorption of small-molecule compounds, particularly hydrophobic drugs, which may reduce the actual drug exposure concentration in chip systems and thereby affect the accuracy of drug screening, toxicity evaluation, and pharmacokinetic studies. This review summarizes recent advances in the adsorption behavior of small-molecule drugs in PDMS-based systems. The mechanisms and influencing factors of PDMS adsorption are discussed, and commonly used measurement and characterization methods are introduced. In addition, engineering strategies for minimizing PDMS absorption and mathematical modeling approaches for concentration correction are summarized. This review aims to provide a reference for evaluating and correcting PDMS-related absorption effects in organ-on-a-chip drug studies.
文章引用：刘砚, 余果. PDMS微流控芯片对 小分子药物吸附的机制、 测定与矫正策略[J]. 临床医学进展, 2026, 16(4): 4718-4727. https://doi.org/10.12677/acm.2026.1641743

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