肺癌术后心房颤动发生特征及危险因素 研究进展
Research Progress on Onset Characteristics and Risk Factors of Postoperative Atrial Fibrillation in Lung Cancer Patients
DOI: 10.12677/acm.2026.1641745, PDF,    科研立项经费支持
作者: 徐 谊, 卢 婷, 许 可, 冯晓延, 熊荣生*：广西壮族自治区南溪山医院(广西壮族自治区第二人民医院)胸外科，广西 桂林
关键词: 肺癌；术后心房颤动；危险因素；手术方式；预测；防治；Lung Cancer； Postoperative Atrial Fibrillation； Risk Factors； Surgical Approach； Prediction； Prevention
摘要: 通过检索国内外相关文献并结合近年来研究结果，本文对肺癌患者术后新发心房颤动(postoperative atrial fibrillation, POAF)的发生情况、高发时段及主要危险因素进行综述。现有研究表明，POAF多集中发生于术后24~72 h，发生率约为8%~42%。其发生与高龄、左心房增大、术式选择、切除范围、手术时长、电解质失衡及术后炎症反应等因素密切相关，核心机制涉及自主神经功能失衡、心房电重构与结构重构、炎症应激及血流动力学异常等多通路共同作用。本文旨在为肺癌患者围术期风险评估、术中干预策略制定及术后监测管理提供参考依据，从而促进POAF的早期识别与有效预防。
Abstract: By reviewing relevant domestic and international literature, this article summarizes the incidence, peak onset period, and major risk factors of postoperative atrial fibrillation (POAF) in patients undergoing lung cancer surgery. Current evidence indicates that POAF most commonly occurs within 24 to 72 hours after surgery, with an incidence ranging from 8% to 42%. Its occurrence is closely associated with advanced age, left atrial enlargement, surgical approach, extent of resection, operative duration, electrolyte imbalance, and postoperative inflammatory response. The core mechanisms involve the combined effects of multiple pathways, such as autonomic nervous system imbalance, atrial electrical and structural remodeling, inflammatory stress and hemodynamic abnormalities. This review aims to provide a reference for perioperative risk assessment, intraoperative intervention strategies, and postoperative monitoring and management in patients with lung cancer, thereby facilitating early identification and effective prevention of POAF.
文章引用：徐谊, 卢婷, 许可, 冯晓延, 熊荣生. 肺癌术后心房颤动发生特征及危险因素 研究进展[J]. 临床医学进展, 2026, 16(4): 4735-4743. https://doi.org/10.12677/acm.2026.1641745

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