营养素与静脉血栓栓塞症的关联研究进展
Research Progress on the Association between Nutrients and Venous Thromboembolism
DOI: 10.12677/acm.2026.1641753, PDF,    科研立项经费支持
作者: 向俊霖, 陈 虹*：重庆医科大学附属第一医院呼吸与危重症医学科，重庆
关键词: 静脉血栓栓塞症；宏量营养素；微量营养素；血栓预防；Venous Thromboembolism； Macronutrients； Micronutrients； Thromboprophylaxis
摘要: 静脉血栓栓塞症(venous thromboembolism, VTE)是临床上的常见并发症，不仅严重威胁患者的生命健康、增加致残和死亡风险，还会带来沉重的医疗经济负担。目前主要依靠抗凝药物预防VTE，但存在出血风险、适用人群有限、患者长期用药依从性差等问题，急需安全有效的非药物防控手段。营养素可以调节人体的凝血–纤溶平衡、炎症反应和血管内皮功能，宏量营养素与微量营养素都会参与VTE的发生发展过程。但目前各类研究对二者和VTE的具体关联、作用机制还没有形成统一结论，研究结果差异较大，也缺乏对这两类营养素与VTE关系的系统整理。本研究系统梳理了宏量、微量营养素和VTE发生发展的关联，分析其调控VTE的核心分子机制，对现有研究的共识与争议进行总结，可为后续构建新的VTE风险评估体系提供参考。
Abstract: Venous thromboembolism (VTE) is a common clinical complication. It not only poses a severe threat to patients’ life and health and elevates the risk of disability and mortality, but also imposes a substantial medical and economic burden. At present, anticoagulant drugs serve as the primary approach for VTE prevention. However, their application is limited by issues such as bleeding risk, restricted eligible populations, and poor long-term medication adherence in patients, highlighting an urgent demand for safe and effective non-pharmacological prevention and control strategies. Nutrients can modulate the human body’s coagulation-fibrinolysis balance, inflammatory response, and vascular endothelial function. Both macronutrients and micronutrients are involved in the initiation and progression of VTE. Nevertheless, current studies have not reached consistent conclusions regarding the specific association and underlying mechanisms between these nutrients and VTE, with highly divergent results. In addition, there remains a lack of systematic collation on the relationship between these two categories of nutrients and VTE. This study systematically reviews the association between macronutrients, micronutrients and the development of VTE, analyzes the core molecular mechanisms by which these nutrients regulate VTE, and summarizes the consensus and controversies in existing research. The results can provide a reference for the subsequent construction of a new VTE risk assessment system.
文章引用：向俊霖, 陈虹. 营养素与静脉血栓栓塞症的关联研究进展[J]. 临床医学进展, 2026, 16(4): 4805-4815. https://doi.org/10.12677/acm.2026.1641753

参考文献

[1] Henke, P.K., Kahn, S.R., Pannucci, C.J., Secemksy, E.A., Evans, N.S., Khorana, A.A., et al. (2020) Call to Action to Prevent Venous Thromboembolism in Hospitalized Patients: A Policy Statement from the American Heart Association. Circulation, 141, e914-e931. [Google Scholar] [CrossRef] [PubMed]
[2] Watson, T., Shantsila, E. and Lip, G.Y. (2009) Mechanisms of Thrombogenesis in Atrial Fibrillation: Virchow’s Triad Revisited. The Lancet, 373, 155-166. [Google Scholar] [CrossRef] [PubMed]
[3] Wendelboe, A.M. and Raskob, G.E. (2016) Global Burden of Thrombosis: Epidemiologic Aspects. Circulation Research, 118, 1340-1347. [Google Scholar] [CrossRef] [PubMed]
[4] Lutsey, P.L. and Zakai, N.A. (2023) Epidemiology and Prevention of Venous Thromboembolism. Nature Reviews Cardiology, 20, 248-262. [Google Scholar] [CrossRef] [PubMed]
[5] Khan, F., Tritschler, T., Kahn, S.R. and Rodger, M.A. (2021) Venous Thromboembolism. The Lancet, 398, 64-77. [Google Scholar] [CrossRef] [PubMed]
[6] 翟振国. 全国VTE防治质控工作进展汇报[Z]. 第二届中国VTE质控大会, 中国北京, 2025-03-28.
https://www.thrombosischina.cn/info/1043/6865.htm
[7] Grosse, S.D., Nelson, R.E., Nyarko, K.A., Richardson, L.C. and Raskob, G.E. (2016) The Economic Burden of Incident Venous Thromboembolism in the United States: A Review of Estimated Attributable Healthcare Costs. Thrombosis Research, 137, 3-10. [Google Scholar] [CrossRef] [PubMed]
[8] Barco, S., Woersching, A.L., Spyropoulos, A.C., Piovella, F. and Mahan, C.E. (2016) European Union-28: An Annualised Cost-of-Illness Model for Venous Thromboembolism. Thrombosis and Haemostasis, 115, 800-808. [Google Scholar] [CrossRef] [PubMed]
[9] Khan, F., Rahman, A., Carrier, M., Kearon, C., Weitz, J.I., Schulman, S., et al. (2019) Long Term Risk of Symptomatic Recurrent Venous Thromboembolism after Discontinuation of Anticoagulant Treatment for First Unprovoked Venous Thromboembolism Event: Systematic Review and Meta-Analysis. BMJ, 366, Article l4363. [Google Scholar] [CrossRef] [PubMed]
[10] Forgo, G., Micieli, E., Ageno, W., Castellucci, L.A., Cesarman‐Maus, G., Ddungu, H., et al. (2022) An Update on the Global Use of Risk Assessment Models and Thromboprophylaxis in Hospitalized Patients with Medical Illnesses from the World Thrombosis Day Steering Committee: Systematic Review and Meta‐Analysis. Journal of Thrombosis and Haemostasis, 20, 409-421. [Google Scholar] [CrossRef] [PubMed]
[11] Kang, H., Jones, B.L., Lo-Ciganic, W., DeRemer, C.E., Dietrich, E.A., Huang, P., et al. (2023) Trajectories of Adherence to Extended Treatment with Direct Oral Anticoagulants and Risks of Recurrent Venous Thromboembolism and Major Bleeding. Journal of Managed Care & Specialty Pharmacy, 29, 1219-1230. [Google Scholar] [CrossRef] [PubMed]
[12] Dehghan, M., Mente, A., Zhang, X., Swaminathan, S., Li, W., Mohan, V., et al. (2017) Associations of Fats and Carbohydrate Intake with Cardiovascular Disease and Mortality in 18 Countries from Five Continents (PURE): A Prospective Cohort Study. The Lancet, 390, 2050-2062. [Google Scholar] [CrossRef] [PubMed]
[13] Hernáez, Á., Castañer, O., Tresserra‐Rimbau, A., Pintó, X., Fitó, M., Casas, R., et al. (2020) Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial. Molecular Nutrition & Food Research, 64, e2000350. [Google Scholar] [CrossRef] [PubMed]
[14] Rocha, H.N.M., Velasco, L.L., Batista, G.M.S., Storch, A.S., Garcia, V.P., Teixeira, G.F., et al. (2024) Ascorbic Acid Prevents Stress-Induced Hypercoagulability in Overweight and Obese Individuals. Scientific Reports, 14, Article No. 3122. [Google Scholar] [CrossRef] [PubMed]
[15] Nie, S., Huang, P., Niu, H., Ding, F., Gong, L., Zou, C., et al. (2025) Vitamin D Deficiency Enhances Platelet Activation and Thrombosis by Regulating VDR/Akt Pathway Based on Platelet Proteomics. European Journal of Pharmacology, 999, Article 177684. [Google Scholar] [CrossRef] [PubMed]
[16] Lutsey, P.L., Steffen, L.M., Virnig, B.A. and Folsom, A.R. (2009) Diet and Incident Venous Thromboembolism: The Iowa Women’s Health Study. American Heart Journal, 157, 1081-1087. [Google Scholar] [CrossRef] [PubMed]
[17] Varraso, R., Kabrhel, C., Goldhaber, S.Z., Rimm, E.B. and Camargo, C.A. (2012) Prospective Study of Diet and Venous Thromboembolism in US Women and Men. American Journal of Epidemiology, 175, 114-126. [Google Scholar] [CrossRef] [PubMed]
[18] Morelli, V.M., de Mutsert, R., de Roos, A., Lamb, H.J., van Hylckama Vlieg, A., Bos, M.H.A., et al. (2020) Association between Hepatic Triglyceride Content and Coagulation Factors: The Netherlands Epidemiology of Obesity Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 40, 3004-3014. [Google Scholar] [CrossRef] [PubMed]
[19] Xiang, Q., Tian, F., Xu, J., Du, X., Zhang, S. and Liu, L. (2022) New Insight into Dyslipidemia‐Induced Cellular Senescence in Atherosclerosis. Biological Reviews, 97, 1844-1867. [Google Scholar] [CrossRef] [PubMed]
[20] Delluc, A., Malécot, J., Kerspern, H., Nowak, E., Carre, J., Mottier, D., et al. (2012) Lipid Parameters, Lipid Lowering Drugs and the Risk of Venous Thromboembolism. Atherosclerosis, 220, 184-188. [Google Scholar] [CrossRef] [PubMed]
[21] Doggen, C.J.M., Smith, N.L., Lemaitre, R.N., Heckbert, S.R., Rosendaal, F.R. and Psaty, B.M. (2004) Serum Lipid Levels and the Risk of Venous Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, 1970-1975. [Google Scholar] [CrossRef] [PubMed]
[22] Chen, F., Peng, D., Xia, Y., Sun, H., Shen, H. and Xia, M. (2024) Identification of Oxylipins and Lipid Mediators in Pulmonary Embolism. Lipids in Health and Disease, 23, Article No. 330. [Google Scholar] [CrossRef] [PubMed]
[23] Jones, W.L., Ramos, C.R., Banerjee, A., Moore, E.E., Hansen, K.C., Coleman, J.R., et al. (2022) Apolipoprotein A-I, Elevated in Trauma Patients, Inhibits Platelet Activation and Decreases Clot Strength. Platelets, 33, 1119-1131. [Google Scholar] [CrossRef] [PubMed]
[24] Lin, L., Luo, P., Yang, M., Wang, J., Hou, W. and Xu, P. (2023) A Bidirectional Mendelian Randomized Study of Classical Blood Lipids and Venous Thrombosis. Scientific Reports, 13, Article No. 3904. [Google Scholar] [CrossRef] [PubMed]
[25] Luo, P., Yuan, Q., Wan, X., Yang, M. and Xu, P. (2023) A Two-Sample Mendelian Randomization Study of Circulating Lipids and Deep Venous Thrombosis. Scientific Reports, 13, Article No. 7432. [Google Scholar] [CrossRef] [PubMed]
[26] Huang, W., Zou, Y., Zhang, K., Yao, S., Tang, S., Wu, H., et al. (2024) Two-Sample Mendelian Randomization Analysis Reveals Causal Relationships between Blood Lipids and Venous Thromboembolism. Haematologica, 109, 2978-2987. [Google Scholar] [CrossRef] [PubMed]
[27] Zheng, X., Jia, R., Li, Y., Liu, T. and Wang, Z. (2020) Omega-3 Fatty Acids Reduce Post-Operative Risk of Deep Vein Thrombosis and Pulmonary Embolism after Surgery for Elderly Patients with Proximal Femoral Fractures: A Randomized Placebo-Controlled, Double-Blind Clinical Trial. International Orthopaedics, 44, 2089-2093. [Google Scholar] [CrossRef] [PubMed]
[28] Yang, J., Cha, L., Wang, Y., Zhang, Q., Tang, X., Shao, J., et al. (2023) L-Palmitoylcarnitine Potentiates Plasmin and tPA to Inhibit Thrombosis. Natural Products and Bioprospecting, 13, Article No. 48. [Google Scholar] [CrossRef] [PubMed]
[29] Liu, Z., Ma, H., Zhang, L., Xu, X., Su, S. and He, X. (2025) Exploring Metabolite-Mediated Links between Lipidome and Deep Vein Thrombosis: Insights from Mendelian Randomization Analysis. Medicine, 104, e41783. [Google Scholar] [CrossRef] [PubMed]
[30] de Moraes Mizurini, D., da Costa Maia, I., de Carvalho Sardinha, F.L., de Queiroz Monteiro, R., Ortiz-Costa, S. and das Graças Tavares do Carmo, M. (2011) Venous Thrombosis Risk: Effects of Palm Oil and Hydrogenated Fat Diet in Rats. Nutrition, 27, 233-238. [Google Scholar] [CrossRef] [PubMed]
[31] Johansson, M., Brækkan, S.K., Giskeødegård, G.F., Wade, K.H., Hindberg, K.D., Timpson, N., et al. (2025) High Concentrations of Polyunsaturated N-3 Fatty Acids in Serum Are Inversely Associated with Risk of Future Incident Venous Thromboembolism—The HUNT Cohort Study. The American Journal of Clinical Nutrition, 122, 1195-1203. [Google Scholar] [CrossRef] 
[32] Reiner, M.F., Stivala, S., Limacher, A., Bonetti, N.R., Méan, M., Egloff, M., et al. (2017) Omega‐3 Fatty Acids Predict Recurrent Venous Thromboembolism or Total Mortality in Elderly Patients with Acute Venous Thromboembolism. Journal of Thrombosis and Haemostasis, 15, 47-56. [Google Scholar] [CrossRef] [PubMed]
[33] Wu, G. (2016) Dietary Protein Intake and Human Health. Food & Function, 7, 1251-1265. [Google Scholar] [CrossRef] [PubMed]
[34] Luo, P., Xu, J., Xu, K., Jing, W., Liu, L. and Xu, P. (2022) Exploring the Genetic Relationship between Deep Vein Thrombosis and Plasma Protein: A New Research Idea. Expert Review of Hematology, 15, 867-873. [Google Scholar] [CrossRef] [PubMed]
[35] Wolberg, A.S. and Sang, Y. (2022) Fibrinogen and Factor XIII in Venous Thrombosis and Thrombus Stability. Arteriosclerosis, Thrombosis, and Vascular Biology, 42, 931-941. [Google Scholar] [CrossRef] [PubMed]
[36] Nossent, A.Y., Eikenboom, J.C.J. and Bertina, R.M. (2007) Plasma Coagulation Factor Levels in Venous Thrombosis. Seminars in Hematology, 44, 77-84. [Google Scholar] [CrossRef] [PubMed]
[37] Lai, Z., Li, J., Zhou, S., Wu, X., Yuan, J., Li, F., et al. (2024) Mutation Ter462GlnextTer17 Introduces a Tail to C-Terminus of Protein C and Causes Venous Thrombosis. Thrombosis Research, 240, Article 109044. [Google Scholar] [CrossRef] [PubMed]
[38] Calzavarini, S., Prince-Eladnani, R., Saller, F., Bologna, L., Burnier, L., Brisset, A.C., et al. (2020) Platelet Protein S Limits Venous but Not Arterial Thrombosis Propensity by Controlling Coagulation in the Thrombus. Blood, 135, 1969-1982. [Google Scholar] [CrossRef] [PubMed]
[39] Neupane, S., Pudasaini, P., Dhakal, B., Awal, S., Thapa, S. and Subedi, B. (2022) Protein S Deficiency with Recurrent Deep Vein Thrombosis and Post Thrombotic Syndrome: A Case Report. Journal of Nepal Medical Association, 60, 892-894. [Google Scholar] [CrossRef] [PubMed]
[40] Ku, C., Yu, X., Zhao, Q.Y., Grzegorski, S.J., Daniel, J.G., Ferguson, A.C., et al. (2025) Loss of Protein C vs Protein S Results in Discrepant Thrombotic Phenotypes. Blood Advances, 9, 545-557. [Google Scholar] [CrossRef] [PubMed]
[41] Thondapu, V., Montes, D., Rosovsky, R., Dua, A., McDermott, S., Lu, M.T., et al. (2021) Venous Thrombosis, Thromboembolism, Biomarkers of Inflammation, and Coagulation in Coronavirus Disease 2019. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 9, 835-844.e4. [Google Scholar] [CrossRef] [PubMed]
[42] Dix, C., Zeller, J., Stevens, H., Eisenhardt, S.U., Shing, K.S.C.T., Nero, T.L., et al. (2022) C-Reactive Protein, Immunothrombosis and Venous Thromboembolism. Frontiers in Immunology, 13, Article ID: 1002652. [Google Scholar] [CrossRef] [PubMed]
[43] Betensky, M., Amankwah, E.K., Brandal, S., Everett, A.D. and Goldenberg, N.A. (2021) Plasma Fibrinolysis, Inflammatory Markers, and Postthrombotic Syndrome: Preliminary Findings from the Kids-Dott Biobank. Blood Advances, 5, 233-239. [Google Scholar] [CrossRef] [PubMed]
[44] Yan, M., Wang, Y., Niu, L., Wang, S., Yu, H., Yin, Q., et al. (2025) Apolipoprotein A-IV Regulates Coagulation and Ischemic Stroke by Potentiating Activated Protein C. Journal of Thrombosis and Haemostasis, 23, 2837-2848. [Google Scholar] [CrossRef] [PubMed]
[45] Konieczyńska, M., Natorska, J., Ząbczyk, M. and Undas, A. (2024) Lipoprotein (a) and Thromboembolism: Current State of Knowledge and Unsolved Issues. Archives of Medical Science, 20, 1770-1783. [Google Scholar] [CrossRef] [PubMed]
[46] Milford, E.M. and Reade, M.C. (2019) Resuscitation Fluid Choices to Preserve the Endothelial Glycocalyx. Critical Care, 23, Article No. 77. [Google Scholar] [CrossRef] [PubMed]
[47] Xia, X., Tie, X., Hong, M. and Yin, W. (2025) Exploration of the Causal Relationship and Mechanisms between Serum Albumin and Venous Thrombosis: A Bidirectional Mendelian Randomization Analysis and Bioinformatics Study. Thrombosis Journal, 23, Article No. 17. [Google Scholar] [CrossRef] [PubMed]
[48] Casulleras, M., Flores-Costa, R., Duran-Güell, M., Alcaraz-Quiles, J., Sanz, S., Titos, E., et al. (2020) Albumin Internalizes and Inhibits Endosomal TLR Signaling in Leukocytes from Patients with Decompensated Cirrhosis. Science Translational Medicine, 12, eaax5135. [Google Scholar] [CrossRef] [PubMed]
[49] Stefanini, L., Lee, R.H., Paul, D.S., O’Shaughnessy, E.C., Ghalloussi, D., Jones, C.I., et al. (2018) Functional Redundancy between RAP1 Isoforms in Murine Platelet Production and Function. Blood, 132, 1951-1962. [Google Scholar] [CrossRef] [PubMed]
[50] Lotfollahzadeh, S., Jose, A., Yang, X., Bathla, T., Lazowski, A., Hoekstra, I., et al. (2025) Dietary Tryptophan Augments Cancer-Associated Venous Thrombogenicity Mitigated by Indoleamine 2,3-Dioxygenase 1 Inhibition. Blood Advances, 9, 4910-4923. [Google Scholar] [CrossRef] [PubMed]
[51] Tokajuk, A., Zakrzeska, A., Chabielska, E. and Car, H. (2019) Whey Protein Concentrate Limits Venous Thrombosis in Rats. Applied Physiology, Nutrition, and Metabolism, 44, 907-910. [Google Scholar] [CrossRef] [PubMed]
[52] Panchagnula, N. and Brasher, W.P. (2024) Hyperglycemia and Venous Thromboembolism. Diagnostics, 14, Article 1994. [Google Scholar] [CrossRef] [PubMed]
[53] Li, X., Weber, N.C., Cohn, D.M., Hollmann, M.W., DeVries, J.H., Hermanides, J., et al. (2021) Effects of Hyperglycemia and Diabetes Mellitus on Coagulation and Hemostasis. Journal of Clinical Medicine, 10, Article 2419. [Google Scholar] [CrossRef] [PubMed]
[54] Yang, D., Wang, M., Zhang, C. and Wang, Y. (2024) Endothelial Dysfunction in Vascular Complications of Diabetes: A Comprehensive Review of Mechanisms and Implications. Frontiers in Endocrinology, 15, Article ID: 1359255. [Google Scholar] [CrossRef] [PubMed]
[55] Pushpakumar, S., Kundu, S. and Sen, U. (2014) Endothelial Dysfunction: The Link between Homocysteine and Hydrogen Sulfide. Current Medicinal Chemistry, 21, 3662-3672. [Google Scholar] [CrossRef] [PubMed]
[56] Zhang, M., Peng, Y., Zhang, J., Du, B., Wang, M., Chen, S., et al. (2025) Dietary Fructose from Added Sugar Beverages and Foods Is Positively Associated with Homocysteine: NHANES 2003-2006. Nutrition Research, 143, 111-129. [Google Scholar] [CrossRef] 
[57] Hu, S., Li, H., Wu, L., Ye, L., Huang, G., Lin, J., et al. (2025) Causal Associations between Diet and Thromboembolism: A 2-Sample Mendelian Randomization Study. Medicine, 104, e46296. [Google Scholar] [CrossRef] 
[58] Zoroddu, M.A., Aaseth, J., Crisponi, G., Medici, S., Peana, M. and Nurchi, V.M. (2019) The Essential Metals for Humans: A Brief Overview. Journal of Inorganic Biochemistry, 195, 120-129. [Google Scholar] [CrossRef] [PubMed]
[59] Guilland, J.C. (2013) Qu’estce qu’une vitamine? Revue Pratique, 63, 1060-1069.
[60] Mohammadifard, N., Humphries, K.H., Gotay, C., Mena-Sánchez, G., Salas-Salvadó, J., Esmaillzadeh, A., et al. (2017) Trace Minerals Intake: Risks and Benefits for Cardiovascular Health. Critical Reviews in Food Science and Nutrition, 59, 1334-1346. [Google Scholar] [CrossRef] [PubMed]
[61] Evstatiev, R. (2016) Eisenmangel, thrombozytose und thromboembolie. Wiener Medizinische Wochenschrift, 166, 437-446. [Google Scholar] [CrossRef] [PubMed]
[62] Henderson, S.J., Stafford, A.R., Leslie, B.A., Kim, P.Y., Vaezzadeh, N., Ni, R., et al. (2015) Zinc Delays Clot Lysis by Attenuating Plasminogen Activation and Plasmin-Mediated Fibrin Degradation. Thrombosis and Haemostasis, 113, 1278-1288. [Google Scholar] [CrossRef] [PubMed]
[63] Gattermann, N., Muckenthaler, M.U., Kulozik, A.E., Metzgeroth, G. and Hastka, J. (2021) The Evaluation of Iron Deficiency and Iron Overload. Deutsches Ärzteblatt international, 118, 847-856. [Google Scholar] [CrossRef] [PubMed]
[64] Wu, J., Zhang, Y., Liu, T., Yang, J., Sun, X. and Gao, X. (2024) The Mechanism of Selenium Regulating the Permeability of Vascular Endothelial Cells through Selenoprotein O. Redox Biology, 70, Article 103063. [Google Scholar] [CrossRef] [PubMed]
[65] Lv, X., Zhao, L., Song, Y., Chen, W. and Tuo, Q. (2024) Deciphering the Role of Copper Homeostasis in Atherosclerosis: From Molecular Mechanisms to Therapeutic Targets. International Journal of Molecular Sciences, 25, Article 11462. [Google Scholar] [CrossRef] [PubMed]
[66] Kim, D., Meza, C.A., Clarke, H., Kim, J. and Hickner, R.C. (2020) Vitamin D and Endothelial Function. Nutrients, 12, Article 575. [Google Scholar] [CrossRef] [PubMed]
[67] Jakubowski, H. and Witucki, Ł. (2025) Homocysteine Metabolites, Endothelial Dysfunction, and Cardiovascular Disease. International Journal of Molecular Sciences, 26, Article 746. [Google Scholar] [CrossRef] [PubMed]
[68] Potaczek, D.P., Jankowska, E.A., Wypasek, E. and Undas, A. (2016) Iron Deficiency: A Novel Risk Factor of Recurrence in Patients after Unprovoked Venous Thromboembolism. Polish Archives of Internal Medicine, 126, 159-165. [Google Scholar] [CrossRef] [PubMed]
[69] Gill, D., Brewer, C.F., Monori, G., Trégouët, D., Franceschini, N., Giambartolomei, C., et al. (2019) Effects of Genetically Determined Iron Status on Risk of Venous Thromboembolism and Carotid Atherosclerotic Disease: A Mendelian Randomization Study. Journal of the American Heart Association, 8, e012994. [Google Scholar] [CrossRef] [PubMed]
[70] Signorelli, S.S., Barbagallo, A., Oliveri Conti, G., Fiore, M., Cristaldi, A. and Ferrante, M. (2024) Oxidative Status, Iron Plasma Levels in Venous Thrombosis Patients. Antioxidants, 13, Article 689. [Google Scholar] [CrossRef] [PubMed]
[71] Kunutsor, S.K., Jae, S.Y. and Laukkanen, J.A. (2022) No Evidence of a Prospective Relationship between Serum Zinc and Venous Thromboembolism in Caucasian Men: A Cohort Study. BioMetals, 35, 785-793. [Google Scholar] [CrossRef] [PubMed]
[72] Kunutsor, S.K., Dey, R.S. and Laukkanen, J.A. (2021) Circulating Serum Copper Is Associated with Atherosclerotic Cardiovascular Disease, but Not Venous Thromboembolism: A Prospective Cohort Study. Pulse, 9, 109-115. [Google Scholar] [CrossRef] [PubMed]
[73] Ferrante, M., Fiore, M., Conti, G.O., Fiore, V., Grasso, A., Copat, C., et al. (2017) Transition and Heavy Metals Compared to Oxidative Parameter Balance in Patients with Deep Vein Thrombosis: A Case-Control Study. Molecular Medicine Reports, 15, 3438-3444. [Google Scholar] [CrossRef] [PubMed]
[74] Xiang, H., Zhou, C., Gan, X., Huang, Y., He, P., Ye, Z., et al. (2024) Relationship of Serum 25‐Hydroxyvitamin D Concentrations, Diabetes, Vitamin D Receptor Gene Polymorphisms and Incident Venous Thromboembolism. Diabetes/Metabolism Research and Reviews, 41, e70014. [Google Scholar] [CrossRef] [PubMed]
[75] Rodabough, R.J., Budrys, N., Johnson, K.C., Berger, J.S., Shikany, J.M., Raiesdana, A., et al. (2015) The Effect of Calcium Plus Vitamin D Supplementation on the Risk of Venous Thromboembolism. Thrombosis and Haemostasis, 113, 999-1009. [Google Scholar] [CrossRef] [PubMed]
[76] Delluc, A., Moineau, M., Tromeur, C., Gouillou, M., Lacut, K., Carré, J., et al. (2016) Serum Levels of 25(OH)D Are Not Associated with Venous Thromboembolism in the Elderly Population. Thrombosis and Haemostasis, 115, 169-175. [Google Scholar] [CrossRef] [PubMed]
[77] Cattaneo, M., Lombardi, R., Lecchi, A., Bucciarelli, P. and Mannucci, P.M. (2001) Low Plasma Levels of Vitamin B6 Are Independently Associated with a Heightened Risk of Deep-Vein Thrombosis. Circulation, 104, 2442-2446. [Google Scholar] [CrossRef] [PubMed]
[78] Hron, G., Lombardi, R., Eichinger, S., Lecchi, A., Kyrle, P.A. and Cattaneo, M. (2007) Low Vitamin B6 Levels and the Risk of Recurrent Venous Thromboembolism. Haematologica, 92, 1250-1253. [Google Scholar] [CrossRef] [PubMed]
[79] Shu, X.J., Li, Z.F., Chang, Y.W., et al. (2017) Effects of Folic Acid Combined with Vitamin B12 on DVT in Patients with Homocysteine Cerebral Infarction. European Review for Medical and Pharmacological Sciences, 21, 2538-2544.
[80] den Heijer, M., Willems, H.P.J., Blom, H.J., Gerrits, W.B.J., Cattaneo, M., Eichinger, S., et al. (2006) Homocysteine Lowering by B Vitamins and the Secondary Prevention of Deep Vein Thrombosis and Pulmonary Embolism: A Randomized, Placebo-Controlled, Double-Blind Trial. Blood, 109, 139-144. [Google Scholar] [CrossRef] [PubMed]
[81] Glynn, R.J., Ridker, P.M., Goldhaber, S.Z., Zee, R.Y.L. and Buring, J.E. (2007) Effects of Random Allocation to Vitamin E Supplementation on the Occurrence of Venous Thromboembolism: Report from the Women’s Health Study. Circulation, 116, 1497-1503. [Google Scholar] [CrossRef] [PubMed]
[82] Al Sulaiman, K., Aljuhani, O., Saleh, K.B., Badreldin, H.A., Al Harthi, A., Alenazi, M., et al. (2021) Ascorbic Acid as an Adjunctive Therapy in Critically Ill Patients with COVID-19: A Propensity Score Matched Study. Scientific Reports, 11, Article No. 17648. [Google Scholar] [CrossRef] [PubMed]
[83] Vučković, B.A., van Rein, N., Cannegieter, S.C., Rosendaal, F.R. and Lijfering, W.M. (2015) Vitamin Supplementation on the Risk of Venous Thrombosis: Results from the MEGA Case-Control Study. The American Journal of Clinical Nutrition, 101, 606-612. [Google Scholar] [CrossRef] [PubMed]
[84] King, J.C., Brown, K.H., Gibson, R.S., Krebs, N.F., Lowe, N.M., Siekmann, J.H., et al. (2016) Biomarkers of Nutrition for Development (Bond)—Zinc Review. The Journal of Nutrition, 146, 858S-885S. [Google Scholar] [CrossRef] [PubMed]
[85] Wang, L., Hung, K., Lin, Y., Chang, Y., Wu, Z., Ho, C., et al. (2020) Age, Gender and Season Are Good Predictors of Vitamin D Status Independent of Body Mass Index in Office Workers in a Subtropical Region. Nutrients, 12, Article 2719. [Google Scholar] [CrossRef] [PubMed]

为你推荐