“铁代谢–炎症–铁死亡”轴与急性缺血性 脑卒中早期神经功能恶化的研究进展
Advances in the “Iron Metabolism-Inflammation-Ferroptosis” Axis in Early Neurological Deterioration after Acute Ischemic Stroke
DOI: 10.12677/acm.2026.1641757, PDF,    科研立项经费支持
作者: 邬蔚琦, 周明瑞, 刘露露, 缪 薇*：昆明医科大学第二附属医院神经内科，云南 昆明
关键词: 急性缺血性脑卒中；早期神经功能恶化；炎症；铁代谢；铁死亡；Acute Ischemic Stroke； Early Neurological Deterioration； Inflammation； Iron Metabolism； Ferroptosis
摘要: 急性缺血性脑卒中(Acute Ischemic Stroke, AIS)后早期神经功能恶化(Early Neurological Deterioration, END)是严重影响患者预后的临床难题，其病理机制复杂，亟待深入阐明。近年来，以“铁代谢–炎症–铁死亡”为核心的病理轴被证实是驱动END的关键恶性循环通路，为理解其发生发展提供了全新视角。本综述旨在系统阐述该轴在END中的作用机制，并归纳其临床监测指标与潜在治疗靶点。
Abstract: Early neurological deterioration (END) after acute ischemic stroke (AIS) is a clinical challenge that severely impacts patients’ prognosis. Its pathological mechanism is complex and urgently needs to be thoroughly elucidated. In recent years, the pathological axis centered on “iron metabolism-inflammation-ferroptosis” has been identified as a key vicious cycle pathway driving END, providing a novel perspective for understanding its occurrence and development. This review aims to systematically elaborate on the mechanism of action of this axis in END, and summarize its clinical monitoring indicators and potential therapeutic targets.
文章引用：邬蔚琦, 周明瑞, 刘露露, 缪薇. “铁代谢–炎症–铁死亡”轴与急性缺血性 脑卒中早期神经功能恶化的研究进展[J]. 临床医学进展, 2026, 16(4): 4841-4848. https://doi.org/10.12677/acm.2026.1641757

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