微波深部热疗对晚期肝细胞癌患者的疗效 及安全性分析
Efficacy and Safety Analysis of Microwave Deep Hyperthermia in Patients with Advanced Hepatocellular Carcinoma
DOI: 10.12677/acm.2026.1641758, PDF,   
作者: 周 璞*：河北北方学院研究生学院，河北 张家口；邢台市人民医院肿瘤内科，河北 邢台；宗力强：沙河市人民医院医学美容科，河北 沙河；贾碧虹, 刘登湘#：邢台市人民医院，河北 邢台；赵 璇：沙河市中医院肛肠皮肤科，河北 沙河；潘 磊：邢台市中心医院心内CCU，河北 邢台；李 莉#：邢台市第五医院，河北 邢台
关键词: 微波深部热疗；肝细胞癌；临床疗效；生活质量；安全性；Microwave Deep Hyperthermia； Hepatocellular Carcinoma； Clinical Efficacy； Quality of Life； Safety
摘要: 目的：探讨微波深部热疗联合药物治疗对晚期肝细胞癌患者的疗效及安全性。方法：采用回顾性分析方法，选取2024年1月至2025年12月邢台市人民医院收治的40例晚期肝细胞癌患者为研究对象，根据治疗方法不同分为热疗组和对照组两组，每组各20例，热疗组患者给予热疗联合药物治疗，对照组仅给予药物治疗。观察治疗4个周期后患者的临床疗效、生活质量及治疗期间出现的不良反应。结果：治疗4个周期后热疗组患者客观缓解率及疾病控制率均高于对照组，差异有统计学意义(P < 0.05)。热疗组对比对照组患者生活质量的改善更明显，差异有统计学意义(P < 0.05)。热疗组与对照组治疗期间不良反应发生率比较，差异无统计学意义(P > 0.05)。结论：微波深部热疗可改善晚期肝细胞癌患者的临床疗效，并未增加不良反应，提示微波深部热疗联合药物治疗是一种具有一定前景的治疗选择。
Abstract: Objective: To explore the efficacy and safety of microwave deep hyperthermia combined with drug therapy in patients with advanced hepatocellular carcinoma. Methods: A retrospective analysis was conducted, involving 40 patients with advanced hepatocellular carcinoma admitted to Xingtai People’s Hospital from January 2024 to December 2025. The patients were divided into a hyperthermia group and a control group, with 20 cases in each group. The hyperthermia group received hyperthermia combined with drug therapy, while the control group received drug therapy alone. Clinical efficacy, quality of life, and adverse reactions during treatment were observed after four treatment cycles. Results: After four treatment cycles, the objective response rate and disease control rate in the hyperthermia group were significantly higher than those in the control group (P < 0.05). The improvement in quality of life was more pronounced in the hyperthermia group compared to the control group (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the hyperthermia group and the control group (P > 0.05). Conclusion: Microwave deep hyperthermia can improve clinical outcomes in patients with advanced hepatocellular carcinoma without increasing adverse reactions, suggesting that microwave deep hyperthermia combined with drug therapy is a promising treatment option.
文章引用：周璞, 宗力强, 贾碧虹, 赵璇, 潘磊, 刘登湘, 李莉. 微波深部热疗对晚期肝细胞癌患者的疗效 及安全性分析[J]. 临床医学进展, 2026, 16(4): 4849-4855. https://doi.org/10.12677/acm.2026.1641758

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