雌二醇在脓毒症及相关器官功能障碍的 最新研究进展
Latest Research Advances on Estradiol in Sepsis and Sepsis-Related Organ Dysfunction
DOI: 10.12677/acm.2026.1641759, PDF,   
作者: 谷立宏, 张 云：吉首大学医学院，湖南 吉首；株洲市中心医院泌尿外一科，湖南 株洲；李钰琦, 田 章, 舒林飞, 谌 磊*：株洲市中心医院泌尿外一科，湖南 株洲
关键词: 雌二醇；脓毒症；器官功能障碍；炎症反应；氧化应激；免疫调节；Estradiol； Sepsis； Organ Dysfunction； Inflammatory Response； Oxidative Stress； Immunomodulation
摘要: 脓毒症是宿主对感染的反应失调所致的危及生命的器官功能障碍，全球发病率和死亡率居高不下。流行病学数据显示脓毒症预后存在显著性别差异，绝经前女性发病率和死亡率低于同龄男性，提示雌激素可能发挥保护作用。雌二醇(E2)作为生物活性最强的雌激素，具有抗炎、抗氧化、保护内皮等多重效应。本文系统综述雌二醇在脓毒症及其相关器官功能障碍(急性肾损伤、心肌病、肝损伤、肺损伤等)中的研究进展，梳理其与疾病预后的临床相关性，阐明其调控炎症、氧化应激和细胞凋亡的分子机制，并分析当前研究的矛盾与争议，探讨其作为脓毒症辅助治疗的临床转化前景与挑战。
Abstract: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, with persistently high global incidence and mortality. Epidemiological data show significant sex-based differences in sepsis outcomes: premenopausal women have lower incidence and mortality than age-matched men, suggesting a potential protective role of estrogen. Estradiol (E2), the most biologically active estrogen, exerts multiple effects including anti-inflammatory, antioxidant, and endothelial-protective actions. This article systematically reviews research progress on estradiol in sepsis and related organ dysfunction (acute kidney injury, septic cardiomyopathy, liver injury, lung injury, etc.), summarizes its clinical associations with prognosis, elucidates molecular mechanisms by which it regulates inflammation, oxidative stress, and apoptosis, and analyzes current inconsistencies and controversies. Finally, it discusses the translational prospects and challenges of estradiol as an adjunctive therapy for sepsis.
文章引用：谷立宏, 李钰琦, 田章, 张云, 舒林飞, 谌磊. 雌二醇在脓毒症及相关器官功能障碍的 最新研究进展[J]. 临床医学进展, 2026, 16(4): 4856-4865. https://doi.org/10.12677/acm.2026.1641759

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