脂蛋白相关磷脂酶A2与全身免疫炎症反应指数在冠心病患者中的表达及临床意义

Expression and Clinical Significance of Lipoprotein-Associated Phospholipase A2 and Systemic Immune-Inflammatory Response Index in Patients with Coronary Heart Disease

摘要: 目的：探讨脂蛋白相关磷脂酶A2 (Lp-PLA2)、全身免疫炎症反应指数(SIIRI)在冠心病患者中的表达水平及其临床意义。方法：纳入行冠脉造影的313例患者，分为冠心病组(226例)和非冠心病组(87例)。比较两组Lp-PLA2、SIIRI水平，采用多因素Logistic回归分析冠心病的独立影响因素。结果：冠心病组Lp-PLA2水平为246.32 (193.80, 297.50) ng/mL，SIIRI水平为317.23 (178.73, 601.30)，均显著高于非冠心病组[201.25 (153.61, 260.49) ng/mL、217.95 (101.47, 314.11)] (P < 0.001)。多因素Logistic回归显示，Lp-PLA2 (OR = 1.008, P = 0.004)、SIIRI (OR = 1.145, P = 0.022)是冠心病的独立危险因素。结论：Lp-PLA2和SIIRI在冠心病患者中显著升高，是冠心病的独立危险因素，可作为冠心病筛查的潜在指标。

Abstract: Objective: To investigate the expression levels and clinical significance of lipoprotein-associated phospholipase A2 (Lp-PLA2) and systemic immune-inflammatory response index (SIIRI) in patients with coronary heart disease (CHD). Methods: A total of 313 patients undergoing coronary angiography were enrolled and divided into the CHD group (226 cases) and the non-CHD group (87 cases). The levels of Lp-PLA2 and SIIRI were compared between the two groups, and multivariate Logistic regression was used to analyze the independent influencing factors of CHD. Results: The levels of Lp-PLA2 and SIIRI in the CHD group were 246.32 (193.80, 297.50) ng/mL and 317.23 (178.73, 601.30), respectively, which were significantly higher than those in the non-CHD group [201.25 (153.61, 260.49) ng/mL and 217.95 (101.47, 314.11), respectively] (P < 0.001). Multivariate Logistic regression showed that Lp-PLA2 (OR = 1.008, P = 0.004) and SIIRI (OR = 1.145, P = 0.022) were independent risk factors for CHD. Conclusion: Lp-PLA2 and SIIRI are significantly elevated in patients with CHD and are independent risk factors for CHD, which can be used as potential indicators for CHD screening.