男性乳腺颗粒细胞瘤1例报道

Male Breast Granular Cell Tumor: A Case Report

摘要: 目的：探讨男性乳腺颗粒细胞瘤的临床病理学特征、鉴别诊断、治疗与预后。方法：收集秦皇岛市第一医院1例男性乳腺颗粒细胞瘤患者的相关信息，进行回顾性总结，包括临床表现，影像学检查，组织病理检查结果等。结果：肿瘤浸润性生长，呈不规则条索或巢状排列，细胞圆形或多边形，胞浆丰富，内含嗜伊红色细颗粒，部分胞浆透亮，核小、圆形，深染，核分裂象不明显。免疫组化：S-100 (+)、S0X-10 (+)、EMA (−)、CD68 (+)、CK8/18 (−)，GATA3 (−)、Ki-67 (+, <2%)。结论：男性乳腺颗粒细胞瘤罕见，组织学常呈浸润性生长、易与乳腺癌混淆，但绝大多数为良性，完整切除后预后良好。因影像学及术中冰冻易误诊，确诊需依赖组织病理及免疫组化。

Abstract: Objective: To explore the clinical and pathological features, differential diagnosis, treatment, and prognosis of granular cell tumor (GCT) of the male breast. Methods: One case of male breast GCT from the First Hospital of Qinhuangdao City was reviewed. Clinical data, imaging findings, and histopathological results were analyzed. Results: The tumor showed infiltrative growth, forming irregular cords or nests. Tumor cells were round or polygonal with abundant eosinophilic granular cytoplasm, some of which appeared clear. Nuclei were small, round, and hyperchromatic, with no obvious mitotic activity. Immunohistochemistry: S-100 (+), SOX-10 (+), EMA (−), CK8/18 (−), GATA3 (−), Ki-67 (+, <2%). Conclusion: Male breast GCT is rare. It often grows invasively and can be confused with breast cancer. However, most cases are benign. Complete excision leads to a good prognosis. Imaging and frozen sections may lead to misdiagnosis. Final diagnosis depends on histopathology and immunohistochemistry.