常用中成药辅助治疗儿童IgA血管炎的机制、疗效及安全性分析

Mechanism, Efficacy and Safety Analysis of Commonly Used Chinese Patent Medicines in the Adjuvant Treatment of Pediatric IgA Vasculitis

摘要: IgA血管炎(IgAV)是儿童时期最常见的系统性小血管炎，肾脏受累是影响远期预后的关键因素，常规西医治疗存在病情反复、不良反应等局限。中成药以免疫调节、抗炎为核心机制，通过多靶点、多通路干预疾病进程，联合西医常规治疗能显著提升疗效、缓解症状、保护肾功能、降低复发率，整体安全性良好。本文系统梳理了白芍总苷胶囊、槐杞黄颗粒、雷公藤多苷片等临床常用中成药辅助治疗儿童IgAV的研究进展，阐述其作用机制、疗效特点及安全性，同时分析了当前研究的不足，为儿童IgAV的中医药辅助治疗及后续研究提供参考。

Abstract: IgA vasculitis (IgAV) is the most common systemic small-vessel vasculitis in children. Renal involvement is a key factor affecting long-term prognosis, and conventional Western medicine treatment has limitations such as recurrent disease and adverse reactions. With immunomodulation and anti-inflammation as the core mechanisms, Chinese patent medicines intervene in the disease process through multi-targets and multi-pathways. Combined with conventional Western medicine treatment, they can significantly improve curative effect, relieve symptoms, protect renal function, reduce recurrence rate, and have good overall safety. This review systematically evaluates the research progress of clinically commonly used Chinese patent medicines such as Total Glucosides of Paeony Capsules, Huaiqihuang Granules, and Tripterygium Glycosides Tablets in the adjuvant treatment of pediatric IgAV, elaborates their action mechanisms, efficacy characteristics and safety, and also analyzes the deficiencies of current research, so as to provide reference for the adjuvant treatment of pediatric IgAV with traditional Chinese medicine and follow-up research.