肿瘤干细胞在肿瘤中的分布规律与临床关联
Distribution Patterns and Clinical Associations of Cancer Stem Cells in Tumors
DOI: 10.12677/acm.2026.1651825, PDF,   
作者: 何雁灵, 吕 炯*：浙江大学医学院附属第一医院口腔颌面外科，浙江 杭州
关键词: 肿瘤干细胞；空间异质性；临床预后；Cancer Stem Cells； Spatial Heterogeneity； Clinical Prognosis
摘要: 肿瘤干细胞(CSCs)是肿瘤内部存在的具有自我更新与分化潜能的细胞亚群，它们促进肿瘤的复发转移与治疗抵抗。本文综述了肿瘤干细胞在肿瘤组织内部的部分特征与其分布影响因素，以及分布特征与临床预后的相关研究。研究表明肿瘤干细胞的分布与肿瘤的缺氧等微环境相关，也存在着不同的信号通路与调控网络维持其干性，同时，肿瘤干细胞的分布规律与临床预后确有相关。尽管现有研究取得进展，但是多数研究关注肿瘤干细胞数量的富集分布特征，仍存在缺乏空间维度信息分析的局限。未来，随着空间组学、人工智能等新技术的发展和应用，我们对肿瘤干细胞的认识也将更加深入，为临床个性化分层治疗提供理论依据。
Abstract: Cancer Stem Cells (CSCs) are a subpopulation of cells within tumors that possess the potential for self‑renewal and differentiation. They drive tumor recurrence, metastasis, and therapeutic resistance. This paper reviews several characteristics of cancer stem cells within tumor tissues, factors influencing their distribution, and research on the correlation between their distribution patterns and clinical prognosis. Studies have shown that the distribution of CSCs is associated with the tumor microenvironment, such as hypoxia. Various signaling pathways and regulatory networks also function to maintain their stemness. Meanwhile, the distribution patterns of CSCs are indeed correlated with clinical prognosis. Although progress has been made in existing research, most studies focus on the enrichment and quantitative distribution of CSCs, which is limited by the lack of spatial dimension analysis. In the future, with the development and application of new technologies including spatial omics and artificial intelligence, our understanding of cancer stem cells will be further deepened, providing a theoretical basis for personalized and stratified clinical therapy.
文章引用：何雁灵, 吕炯. 肿瘤干细胞在肿瘤中的分布规律与临床关联[J]. 临床医学进展, 2026, 16(5): 355-364. https://doi.org/10.12677/acm.2026.1651825

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