中蒙药抗癫痫作用机制研究进展：基于大鼠 癫痫模型的系统综述
Advances in the Mechanisms of Action of Traditional Chinese and Mongolian Medicines in Epilepsy Treatment: A Systematic Review Using Rat Epilepsy Models
DOI: 10.12677/acm.2026.1651838, PDF,    科研立项经费支持
作者: 杨涌禄, 郝 丽, 贾凯茹, 赵 璐, 李珮荣, 昝曼杰：内蒙古医科大学第一临床医学院，内蒙古 呼和浩特；陈柏谕, 付俊鲜, 李天霞, 贾月欣, 乔治东, 潘 浩, 杨光路*：内蒙古医科大学附属医院儿科，内蒙古 呼和浩特
关键词: 癫痫；中药；蒙药；癫痫大鼠；Epilepsy； Traditional Chinese Medicine； Mongolian Medicine； Epileptic Rats
摘要: 癫痫(epilepsy)是一种以具有持久性的产生癫痫发作的倾向为特征的慢性脑部疾病。针对膜离子通道或GABA能神经传递的抗癫痫药物是控制癫痫发作的首选，但药物耐药性和不良反应在很大程度上限制了现有抗癫痫药物的应用。这更凸显了传统中蒙药在治疗癫痫中显示出独特优势，近年来，对于中蒙药的研究已经从过去的循证医学证据发展到更具系统性的机制方面，这为治疗癫痫提供了新思路和新方案。本文系统综述了近5年来中蒙药及其活性成分在大鼠癫痫模型中的治疗作用及机制进展，其具有多靶点、多通路的作用特点，并在此基础上提出未来研究方向，旨在推动中蒙药在癫痫治疗中的现代化与规范化进程。
Abstract: Epilepsy is a chronic brain disorder characterized by a persistent tendency to experience seizures. Antiepileptic drugs that target membrane ion channels or GABAergic neurotransmission are the first-line treatments for controlling seizures. However, drug resistance and side effects significantly limit the use of these medications. This highlights the unique advantages of traditional Chinese and Mongolian medicines in treating epilepsy. In recent years, research on these medicines has progressed from focusing on evidence-based medical data to exploring more systematic mechanisms of action, thereby providing new approaches and treatment options for epilepsy. This article systematically reviews the therapeutic effects and mechanisms of traditional Chinese and Mongolian medicines and their active ingredients in rat epilepsy models over the past five years. These medicines act through multiple targets and pathways. Based on this research, future directions for study are proposed, with the aim of advancing the modernization and standardization of the use of traditional Chinese and Mongolian medicines in epilepsy treatment.
文章引用：杨涌禄, 郝丽, 贾凯茹, 赵璐, 李珮荣, 昝曼杰, 陈柏谕, 付俊鲜, 李天霞, 贾月欣, 乔治东, 潘浩, 杨光路. 中蒙药抗癫痫作用机制研究进展：基于大鼠 癫痫模型的系统综述[J]. 临床医学进展, 2026, 16(5): 477-486. https://doi.org/10.12677/acm.2026.1651838

参考文献

[1] Li, G., Zhang, S., Cheng, Y., Lu, Y., Jia, Z., Yang, X., et al. (2022) Baicalin Suppresses Neuron Autophagy and Apoptosis by Regulating Astrocyte Polarization in Pentylenetetrazol-Induced Epileptic Rats and PC12 Cells. Brain Research, 1774, Article ID: 147723. [Google Scholar] [CrossRef] [PubMed]
[2] Yang, J., Jia, Z., Xiao, Z., Zhao, J., Lu, Y., Chu, L., et al. (2021) Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects through Activating TLR4/MYD88/Caspase-3 Pathway in Rats. Drug Design, Development and Therapy, 15, 3163-3180. [Google Scholar] [CrossRef] [PubMed]
[3] Xie, Z., Zhao, Y., Wang, Y., Song, W. and Li, G. (2025) Apigenin Regulating PI3K/AKT Pathway to Improve Depressive Behavior in Epileptic Rats. Combinatorial Chemistry & High Throughput Screening. [Google Scholar] [CrossRef] [PubMed]
[4] Lu, W., Wu, Z., Zhang, C., Gao, T., Ling, X., Xu, M., et al. (2022) Jujuboside a Exhibits an Antiepileptogenic Effect in the Rat Model via Protection against Traumatic Epilepsy-Induced Oxidative Stress and Inflammatory Responses. Evidence-Based Complementary and Alternative Medicine, 2022, Article ID: 7792791. [Google Scholar] [CrossRef] [PubMed]
[5] Guo, Y., Cai, Y. and Zhang, X. (2020) Icariin Ameliorates the Cognitive Function in an Epilepsy Neonatal Rat Model by Blocking the GluR2/ERK I/II Pathway. Folia Neuropathologica, 58, 245-252. [Google Scholar] [CrossRef] [PubMed]
[6] Yang, C.S., Chiu, S.C., Liu, P.Y., Wu, S.N., Lai, M.C. and Huang, C.W. (2021) Gastrodin Alleviates Seizure Severity and Neuronal Excitotoxicities in the Rat Lithium-Pilocarpine Model of Temporal Lobe Epilepsy via Enhancing GABAergic Transmission. Journal of Ethnopharmacology, 269, Article ID: 113751. [Google Scholar] [CrossRef] [PubMed]
[7] Chen, L., Li, J., Fang, C. and Wang, J. (2025) Metabolomics-Based Study on the Anticonvulsant Mechanism of Acorus Tatarinowii: GABA Transaminase Inhibition Alleviates Ptz-Induced Epilepsy in Rats. Metabolites, 15, Article No. 175. [Google Scholar] [CrossRef] [PubMed]
[8] Liu, C., Sun, J., Shen, X., Li, S., Luo, S., Chen, N., et al. (2024) Peimine Promotes Microglial Polarization to the M2 Phenotype to Attenuate Drug-Resistant Epilepsy through Suppressing the TLR4/NF-κB/HIF-1α Signaling Pathway in a Rat Model and in BV-2 Microglia. Heliyon, 10, e34987. [Google Scholar] [CrossRef] [PubMed]
[9] Wang, Y., Li, C., Xiong, Z., Chen, N., Wang, X., Xu, J., et al. (2022) Up-and-Coming Anti-Epileptic Effect of Aloesone in Aloe Vera: Evidenced by Integrating Network Pharmacological Analysis, in Vitro, and in Vivo Models. Frontiers in Pharmacology, 13, Article ID: 962223. [Google Scholar] [CrossRef] [PubMed]
[10] Li, X., Liu, Y., Wang, S., Jiang, Y., Algradi, A.M., Zhou, Y., et al. (2022) The Aerial Parts of Bupleurum chinense DC. Aromatic Oil Attenuate Kainic Acid‐Induced Epilepsy‐Like Behavior and Its Potential Mechanisms. BioMed Research International, 2022, Article ID: 1234612. [Google Scholar] [CrossRef] [PubMed]
[11] Zhang, J., Zhu, C., Jin, Y., Shen, W., Pan, Y. and Shen, Y. (2023) Ginsenoside Rg1 Improved Learning and Memory Ability and Reduces Neuronal Apoptosis in Epileptic Rats through ERK/CREB/BDNF Signal Pathway. Biochemical and Biophysical Research Communications, 675, 26-32. [Google Scholar] [CrossRef] [PubMed]
[12] Zhao, J., Qin, X., Yang, L., Guo, H., Chen, S., Tian, K., et al. (2025) Application of TCM Network Pharmacology and Experimental Verification to Explore the Mechanism of Kaempferol against Epilepsy. Brain Research Bulletin, 220, Article ID: 111150. [Google Scholar] [CrossRef] [PubMed]
[13] Zhao, X., Liang, L., Xu, R., Cheng, P., Jia, P., Bai, Y., et al. (2022) Revealing the Antiepileptic Effect of α-Asaronol on Pentylenetetrazole-Induced Seizure Rats Using NMR-Based Metabolomics. ACS Omega, 7, 6322-6334. [Google Scholar] [CrossRef] [PubMed]
[14] Xia, S., Yang, P., Li, F., Yu, Q., Kuang, W., Zhu, Y., et al. (2021) Chaihu-Longgu-Muli Decoction Exerts an Antiepileptic Effect in Rats by Improving Pyroptosis in Hippocampal Neurons. Journal of Ethnopharmacology, 270, Article ID: 113794. [Google Scholar] [CrossRef] [PubMed]
[15] Feng, G., Liu, X., Wang, B., Li, R., Chang, Y., Guo, N., et al. (2023) Exploring the Mechanism of Chaihujia Longgu Muli Decoction in the Treatment of Epilepsy in Rats Based on the RhoA/ROCK Signaling Pathway. Molecular Biology Reports, 50, 3389-3399. [Google Scholar] [CrossRef] [PubMed]
[16] Wang, Q., Qin, B., Yu, H., Zeng, J., Fan, J., Wu, Q., et al. (2025) Mitigating Effects of Jiawei Chaihu Shugan Decoction on Necroptosis and Inflammation of Hippocampal Neurons in Epileptic Mice. Scientific Reports, 15, Article No. 4649. [Google Scholar] [CrossRef] [PubMed]
[17] 董笑克, 李中浩, 刘冲冲, 等. 柴贝止痫汤下调海马p-Tau表达改善癫痫大鼠认知功能[J]. 中华中医药杂志, 2020, 35(5): 2369-2373.
[18] 梁韡斌, 张高炼, 郭建辉, 等. Keap1/Nrf2/HO-1/GPX4信号通路阻断癫痫大鼠海马神经元铁死亡机制及草果知母汤的干预效应[J]. 中西医结合心脑血管病杂志, 2022, 20(18): 3323-3329.
[19] Yu, D., Li, S., Li, X., Zhang, X. and Guo, D. (2025) Xianyu Capsule Ameliorates Neuroinflammatory and Glycerophospholipid Metabolism in Lithium-Pilocarpine-Induced Acute Epilepsy. Frontiers in Nutrition, 12, Article ID: 1625533. [Google Scholar] [CrossRef] 
[20] 傅卓, 杨光路, 赵晶晶, 等. 蒙药朝伦雄胡-5对癫痫模型大鼠的治疗效果[J]. 内蒙古医科大学学报, 2022, 44(6): 577-580.
[21] 贾月欣. 蒙药朝伦雄胡-5对癫痫持续状态大鼠模型海马中VEGF表达影响的研究[D]: [硕士学位论文]. 呼和浩特: 内蒙古医科大学, 2022.

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