农村老年人口腔衰弱与功能衰退的相关性及经济毒性研究进展
Research Progress on the Correlation between Oral Frailty and Functional Decline among Rural Older Adults, and Associated Financial Toxicity
DOI: 10.12677/ns.2026.155142, PDF,   
作者: 黄紫仪, 陈换利:吉首大学医学院,湖南 吉首;谭江红*:株洲市中心医院,湖南 株洲
关键词: 农村老年人口腔衰弱功能衰退经济毒性护理干预Rural Older Adults Oral Frailty Functional Decline Economic Toxicity Nursing Interventions
摘要: 口腔衰弱作为近年来老年综合征的研究热点,与躯体功能衰退密切相关,受农村地域特征、传统观念、口腔医疗资源匮乏及经济基础薄弱等因素影响,农村老年人更易因口腔衰弱陷入“功能衰退–经济负担加重”的恶性循环,并可能引发显著的经济负担,甚至导致返贫。本文从口腔衰弱的概念入手,综述老年人口腔衰弱与功能衰退的相关性、作用机制、引发的经济毒性效应,以及现有的干预措施与公共政策,为基层研究老年群体口腔健康管理提供新视角,促进健康老龄化。
Abstract: As a research hotspot in the field of geriatric syndromes in recent years, oral frailty is closely associated with the decline in physical function. Influenced by factors such as rural geographical characteristics, traditional beliefs, limited access to oral healthcare services, and weak economic foundations, rural older adults are more likely to fall into a vicious cycle of “functional decline-increased economic burden” due to oral frailty. This may further lead to significant economic toxicity and even a return to poverty. This article begins with the concept of oral frailty and provides a review of the correlation between oral frailty and functional decline in older adults, the underlying mechanisms, the resulting economic toxicity, as well as existing interventions and public policies. It aims to offer new perspectives for primary care research on oral health management in older populations and to promote healthy aging.
文章引用:黄紫仪, 陈换利, 谭江红. 农村老年人口腔衰弱与功能衰退的相关性及经济毒性研究进展[J]. 护理学, 2026, 15(5): 45-56. https://doi.org/10.12677/ns.2026.155142

参考文献

[1] 杨琰, 朱锋, 李艳芬, 等. 老年口腔健康脆弱性治理机制探索[J]. 中华老年口腔医学杂志, 2025, 23(5): 385-390.
[2] Huang, X., Kang, L. and Bi, J. (2025) Epidemiology of Oral Health in Older Adults Aged 65 or Over: Prevalence, Risk Factors and Prevention. Aging Clinical and Experimental Research, 37, Article No. 193. [Google Scholar] [CrossRef] [PubMed]
[3] Tanaka, T., Takahashi, K., Hirano, H., Kikutani, T., Watanabe, Y., Ohara, Y., et al. (2018) Oral Frailty as a Risk Factor for Physical Frailty and Mortality in Community-Dwelling Elderly. The Journals of Gerontology: Series A, 73, 1661-1667. [Google Scholar] [CrossRef] [PubMed]
[4] 台保军. 中国居民口腔健康状况及防控策略第四次全国口腔健康流行病学调查结果解读[C]//中华口腔医学会老年口腔医学专业委员会. 第十三次全国老年口腔医学学术年会论文汇编. 北京: 中华口腔医学会口腔预防专委会; 武汉: 武汉大学口腔医学院, 2018: 16-17.
[5] 马君英, 李恩洪, 洪飞若, 等. 老年人口腔衰弱预防和管理的最佳证据总结[J]. 护理与康复, 2025, 24(9): 66-72.
[6] Hakeem, F.F., Bernabé, E. and Sabbah, W. (2021) Association between Oral Health and Frailty among American Older Adults. Journal of the American Medical Directors Association, 22, 559-563.e2. [Google Scholar] [CrossRef] [PubMed]
[7] Hakeem, F.F., Bernabé, E. and Sabbah, W. (2019) Association between Oral Health and Frailty: A Systematic Review of Longitudinal Studies. Gerodontology, 36, 205-215. [Google Scholar] [CrossRef] [PubMed]
[8] 于建娇, 朱火兰, 张玉莲, 等. 老年住院患者口腔健康与衰弱的相关性[J]. 中华老年多器官疾病杂志, 2023, 22(9): 652-657.
[9] 胡慧敏, 李晨, 卢俊伟, 等. 营养风险在老年住院患者口腔衰弱与衰弱间的中介效应研究[J]. 护理管理杂志, 2025, 25(9): 786-789+823.
[10] Yang, C., Gao, Y., An, R., Lan, Y., Yang, Y. and Wan, Q. (2024) Oral Frailty: A Concept Analysis. Journal of Advanced Nursing, 80, 3134-3145. [Google Scholar] [CrossRef] [PubMed]
[11] 冯晓彤, 蒋微, 赵秋艳, 等. 老年人口腔衰弱与认知衰弱相关性研究进展[J]. 四川医学, 2025, 46(10): 1179-1184.
[12] 华玮怡, 邵瑜娇, 刘锦秀, 等. 领悟社会支持与营养在农村老年人口腔衰弱与身体衰弱间的链式中介作用[J]. 蚌埠医科大学学报, 2025, 50(8): 1021-1027.
[13] Zafar, S.Y., Peppercorn, J.M., Schrag, D., Taylor, D.H., Goetzinger, A.M., Zhong, X., et al. (2013) The Financial Toxicity of Cancer Treatment: A Pilot Study Assessing Out-of-Pocket Expenses and the Insured Cancer Patient’s Experience. The Oncologist, 18, 381-390. [Google Scholar] [CrossRef] [PubMed]
[14] 郭淑珂, 赛娅热·雪克拉提, 徐琪鸿, 等. 口腔衰弱与老年综合征的相关性研究进展[J]. 实用心电与临床诊疗, 2025, 34(4): 610-614+619.
[15] Baniasadi, K., Armoon, B., Higgs, P., Bayat, A., Mohammadi Gharehghani, M.A., Hemmat, M., et al. (2021) The Association of Oral Health Status and Socio‐Economic Determinants with Oral Health‐Related Quality of Life among the Elderly: A Systematic Review and Meta‐Analysis. International Journal of Dental Hygiene, 19, 153-165. [Google Scholar] [CrossRef] [PubMed]
[16] Li, P., Xie, L., Ou, Y., et al. (2025) Adverse Health Outcomes of Oral Frailty in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. Archives of Gerontology and Geriatrics, 139, Article ID: 106004. [Google Scholar] [CrossRef
[17] Atchison, K. and Dolan, T. (1990) Development of the Geriatric Oral Health Assessment Index. Journal of Dental Education, 54, 680-687. [Google Scholar] [CrossRef
[18] Kakudate, N., Morita, M. and Kawanami, M. (2008) Oral Health Care-Specific Self‐Efficacy Assessment Predicts Patient Completion of Periodontal Treatment: A Pilot Cohort Study. Journal of Periodontology, 79, 1041-1047. [Google Scholar] [CrossRef] [PubMed]
[19] 辛蔚妮, 凌均棨.《口腔健康影响程度量表(OHIP-14中文版)》与《老年口腔健康评价指数(GOHAI中文版)》的比较研究[J]. 口腔医学研究, 2014, 30(3): 252-257.
[20] 王优, 彭爽, 周芙玲. 口腔衰弱对老年慢性疾病的影响及管理策略[J]. 临床口腔医学杂志, 2026, 42(1): 57-61.
[21] Dou, J., Liu, H., Mei, Y., Wang, S., Zhang, Y., Zhao, S., et al. (2025) Prevalence of Oral Frailty in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. Frontiers in Public Health, 13, Article ID: 1423387. [Google Scholar] [CrossRef] [PubMed]
[22] Li, T., Shen, Y., Leng, Y., Zeng, Y., Li, L., Yang, Z., et al. (2024) The Prevalence of Oral Frailty among Older Adults: A Systematic Review and Meta-Analysis. European Geriatric Medicine, 15, 645-655. [Google Scholar] [CrossRef] [PubMed]
[23] Huang, P., Wu, L., Zhang, R., Chen, S., Zhang, Y. and Chen, Y. (2025) Systematic Review and Meta-Analysis on the Prevalence and Risk Factors of Oral Frailty among Older Adults. Frontiers in Medicine, 12, Article ID: 1512927. [Google Scholar] [CrossRef] [PubMed]
[24] 唐吉, 唐小艳, 曾黎, 等. 贵州省农村地区老年人口腔衰弱的流行现况及影响因素分析[J]. 中国慢性病预防与控制, 2023, 31(5): 327-331.
[25] 王志燕, 高欢玲, 杨玉霖, 等. 山西省农村空巢老人口腔健康与衰弱的相关性研究[J]. 实用老年医学, 2021, 35(10): 1054-1057.
[26] 于浩, 叶学荣, 陈泓颖, 等. 住院老年高血压患者衰弱状态与口腔健康的相关性研究及其对临床预后影响的分析[J]. 中国循证心血管医学杂志, 2024, 16(12): 1520-1523.
[27] 李苏婷, 刘天云, 计全月, 等. 老年吞咽障碍和口腔衰弱的相关性研究[J]. 中国老年保健医学, 2025, 23(1): 114-118.
[28] 陈丽娟, 黄欢欢, 胥利, 等. 社区老年人口腔衰弱现状及与肌少症的相关性研究[J]. 蚌埠医科大学学报, 2025, 50(8): 1045-1049.
[29] 李毛毛, 张飞, 沈鑫, 等. 老年人口腔衰弱与跌倒关系的研究进展[J]. 实用老年医学, 2024, 38(9): 876-879+888.
[30] Zhang, X., Wu, X. and Chen, W. (2022) The Association between Number of Teeth and Cognitive Frailty in Older Adults: A Cross-Sectional Study. The Journal of nutrition, health and aging, 26, 430-438. [Google Scholar] [CrossRef] [PubMed]
[31] Ma, L., Zhang, L., Sun, F., Li, Y. and Tang, Z. (2019) Cognitive Function in Prefrail and Frail Community-Dwelling Older Adults in China. BMC Geriatrics, 19, Article No. 53. [Google Scholar] [CrossRef] [PubMed]
[32] Lozupone, M., Panza, F., Dibello, V., Manfredini, D., Dibello, A., Zupo, R., et al. (2021) Oral Frailty and Neurodegeneration in Alzheimer’s Disease. Neural Regeneration Research, 16, 2149-2153. [Google Scholar] [CrossRef] [PubMed]
[33] Kobayashi, T., Kubota, M., Takahashi, T., Nakasato, A., Nomura, T., Furuya, J., et al. (2018) Effects of Tooth Loss on Brain Structure: A Voxel-Based Morphometry Study. Journal of Prosthodontic Research, 62, 337-341. [Google Scholar] [CrossRef] [PubMed]
[34] Galindo-Moreno, P., Lopez-Chaichio, L., Padial-Molina, M., Avila-Ortiz, G., O’valle, F., Ravida, A., et al. (2022) The Impact of Tooth Loss on Cognitive Function. Clinical Oral Investigations, 26, 3493-3500. [Google Scholar] [CrossRef] [PubMed]
[35] 王凤, 郭琪, 马微波, 等. 老年人口腔健康状况与认知功能的关联性[J]. 中华老年医学杂志, 2021, 40(4): 433-437.
[36] Bulthuis, M.S., van Gennip, L.L.A., Thomas, R.Z., Bronkhorst, E.M., Laheij, A.M.G.A., Raber-Durlacher, J.E., et al. (2022) Caries Progression after Haematopoietic Stem Cell Transplantation and the Role of Hyposalivation. Caries Research, 56, 187-196. [Google Scholar] [CrossRef] [PubMed]
[37] 苏荣, 朱红梅, 刘娟, 等. 老年胃肠道肿瘤患者口腔衰弱现状及影响因素分析[J]. 中国医药导报, 2025, 22(17): 135-140.
[38] Liu, M., Liu, B., Shen, J., Qian, S., Lai, H., Yuan, C., et al. (2024) Low Energy Intake and Nutritional Maladaptation in Terminal Stage iv Periodontitis. Journal of Clinical Periodontology, 51, 1147-1156. [Google Scholar] [CrossRef] [PubMed]
[39] Poisson, P., Laffond, T., Campos, S., Dupuis, V. and Bourdel‐Marchasson, I. (2016) Relationships between Oral Health, Dysphagia and Undernutrition in Hospitalised Elderly Patients. Gerodontology, 33, 161-168. [Google Scholar] [CrossRef] [PubMed]
[40] Chouinard, J. (2000) Dysphagia in Alzheimer Disease: A Review. Journal of Nutrition, Health & Aging, 4, 214-217.
[41] 贾琳, 陈文莉, 石晶, 等. 维持性血液透析患者慢性牙周疾病与营养不良-炎症复合性综合征相关性的研究[J]. 临床肾脏病杂志, 2019, 19(6): 411-415.
[42] Ishii, M., Yamaguchi, Y., Hamaya, H., Iwata, Y., Takada, K., Ogawa, S., et al. (2022) Influence of Oral Health on Frailty in Patients with Type 2 Diabetes Aged 75 Years or Older. BMC Geriatrics, 22, Article No. 145. [Google Scholar] [CrossRef] [PubMed]
[43] 陆旦娟. 2型糖尿病患者糖化血红蛋白、血脂与口腔健康生活质量的相关性研究[D]: [硕士学位论文]. 南宁: 广西医科大学, 2021.
[44] Nishimoto, M., Tanaka, T., Hirano, H., Watanabe, Y., Ohara, Y., Shirobe, M., et al. (2023) Severe Periodontitis Increases the Risk of Oral Frailty: A Six-Year Follow-Up Study from Kashiwa Cohort Study. Geriatrics, 8, Article 25. [Google Scholar] [CrossRef] [PubMed]
[45] 李易, 张紫嫣, 邹炎铃, 等. 住院癌症患者口腔衰弱现状及影响因素分析[J]. 护理学杂志, 2024, 39(3): 49-52.
[46] Lin, H., Wang, X., Tian, M., Li, X. and Tan, H. (2022) Betel Quid Chewing and Oral Potential Malignant Disorders and the Impact of Smoking and Drinking: A Meta-Analysis. World Journal of Clinical Cases, 10, 3131-3142. [Google Scholar] [CrossRef] [PubMed]
[47] 陈佳楠, 赵阳鹏, 张倩, 等. 海军基地官兵吸烟与口腔健康调查研究[J]. 临床军医杂志, 2025, 53(2): 179-180.
[48] Tonetti, M.S., Jepsen, S., Jin, L. and Otomo‐Corgel, J. (2017) Impact of the Global Burden of Periodontal Diseases on Health, Nutrition and Wellbeing of Mankind: A Call for Global Action. Journal of Clinical Periodontology, 44, 456-462. [Google Scholar] [CrossRef] [PubMed]
[49] 王敏, 杨文娟, 廖婷, 等. 社区老年人口腔衰弱风险预测模型的构建及验证[J]. 中华护理杂志, 2025, 60(3): 274-280.
[50] Nagayoshi, M., Higashi, M., Takamura, N., Tamai, M., Koyamatsu, J., Yamanashi, H., et al. (2017) Social Networks, Leisure Activities and Maximum Tongue Pressure: Cross-Sectional Associations in the Nagasaki Islands Study. BMJ Open, 7, e014878. [Google Scholar] [CrossRef] [PubMed]
[51] Tsakos, G., Sabbah, W., Chandola, T., Newton, T., Kawachi, I., Aida, J., et al. (2013) Social Relationships and Oral Health among Adults Aged 60 Years or Older. Psychosomatic Medicine, 75, 178-186. [Google Scholar] [CrossRef] [PubMed]
[52] Mills, C.M., Keller, H.H., DePaul, V.G. and Donnelly, C. (2023) Social Network Factors Affect Nutrition Risk in Middle-Aged and Older Adults: Results from the Canadian Longitudinal Study on Aging. The Journal of nutrition, health and aging, 27, 46-58. [Google Scholar] [CrossRef] [PubMed]
[53] Wu, J., Lin, D., Chen, W., Zhang, L., Shen, X., Fu, D., et al. (2025) Research Status and Hotspots of Oral Frailty in Older Adults: A Bibliometric Analysis from 2013 to 2024. Frontiers in Oral Health, 6, Article ID: 1533159. [Google Scholar] [CrossRef] [PubMed]
[54] Zafar, S.Y. and Abernethy, A.P. (2013) Financial Toxicity, Part I: A New Name for a Growing Problem. Oncology, 27, 80-149.
[55] Somay, E. (2025) Comment on “Association between Tooth Loss and Geriatric Syndromes in Older Adults: A Cohort Study from a Rural Area in Eastern China”. Aging Clinical and Experimental Research, 37, Article No. 261. [Google Scholar] [CrossRef
[56] Gao, Q., Wang, X., Jiang, Y., Chen, W., Gao, K. and Shi, Y. (2025) Oral Health and Nutrition: Addressing Disparities in Socioeconomically Disadvantaged Older Adults in Rural China. BMC Public Health, 25, Article No. 977. [Google Scholar] [CrossRef] [PubMed]
[57] Hiroshimaya, T., Kawagoe, Y., Fukuhara, K., Ijichi, H. and Tamaki, N. (2025) Relationship between Oral Hypofunction and Medical Expenditure in Older Adults in Japan. Scientific Reports, 15, Article No. 1874. [Google Scholar] [CrossRef] [PubMed]
[58] 肖圣军, 原静民, 徐海艳, 等. 慢性阻塞性肺疾病患者经济毒性的研究进展[J]. 现代医药卫生, 2026, 42(1): 48-52+57.
[59] Tian, Z., Wang, Y., Li, Y., Lu, J., Song, L., Ding, L., et al. (2023) Defining the Connotations of Oral Health Literacy Using the Conceptual Composition Method. International Journal of Environmental Research and Public Health, 20, 3518. [Google Scholar] [CrossRef] [PubMed]
[60] 王琳, 鞠梅, 王婷, 等. 社区老年人口腔衰弱风险现状及影响因素分析[J]. 护理学杂志, 2023, 38(18): 112-116.
[61] 庄友梅, 张淼, 刘菁彧. 新疆和田地区农村中老年人口腔龋病状况及影响因素分析[J]. 实用预防医学, 2023, 30(9): 1069-1072.
[62] Sigsgaard, A.M., Bolvig, I., Jensen, K.D., Altmann, S., Hede, B. and Øzhayat, E.B. (2024) Oral Health Promotion and Labour Market Prospects of Socially Disadvantaged and Unemployed People—A Randomised Controlled Trial. Scandinavian Journal of Public Health, 52, 71-79. [Google Scholar] [CrossRef] [PubMed]
[63] 雷泽惠, 黎明. “两不愁三保障”的生成逻辑与当代价值研究[J]. 经济研究导刊, 2025(6): 10-13.
[64] 王玟璇, 马俪瑄, 韩亚轩, 等. 健康生态学视角下社区老年人口腔衰弱影响因素的潜在类别分析[J]. 天津护理, 2026, 34(1): 18-24.
[65] 刘曦然, 王彩霞, 王雅桤, 等. 老年糖尿病患者口腔衰弱发生机制、影响因素及其干预策略的研究进展[J]. 中国老年学杂志, 2025, 45(24): 6135-6140.
[66] 刘格, 刘畅. 多任务协同干预在老年口腔衰弱中的应用进展[J]. 口腔医学研究, 2025, 41(9): 737-742.
[67] Prabandari, Y., Astuti, N., Hanindriyo, L. and Probosuseno, (2023) Types and Effects of Oral Exercise on Oral Function in the Elderly: A Scoping Review of Interventional Studies. Journal of International Oral Health, 15, 328-336. [Google Scholar] [CrossRef
[68] Iwasaki, M., Motokawa, K., Watanabe, Y., Shirobe, M., Inagaki, H., Edahiro, A., et al. (2020) Association between Oral Frailty and Nutritional Status among Community-Dwelling Older Adults: The Takashimadaira Study. The Journal of Nutrition, Health and Aging, 24, 1003-1010. [Google Scholar] [CrossRef] [PubMed]
[69] Ticinesi, A., Meschi, T., Lauretani, F., Felis, G., Franchi, F., Pedrolli, C., et al. (2016) Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, N-3 Polyunsaturated Fatty Acids and Whey Proteins. Nutrients, 8, Article 186. [Google Scholar] [CrossRef] [PubMed]
[70] Matsuo, K., Kito, N., Ogawa, K., Izumi, A., Kishima, M., Itoda, M., et al. (2021) Improvement of Oral Hypofunction by a Comprehensive Oral and Physical Exercise Programme Including Textured Lunch Gatherings. Journal of Oral Rehabilitation, 48, 411-421. [Google Scholar] [CrossRef] [PubMed]
[71] Park, H., Nam, H., Seo, H. and Hwang, S. (2015) Change of Periodontal Inflammatory Indicators through a 4-Week Weight Control Intervention Including Caloric Restriction and Exercise Training in Young Koreans: A Pilot Study. BMC Oral Health, 15, Article No. 109. [Google Scholar] [CrossRef] [PubMed]
[72] Iwao, Y., Shigeishi, H., Takahashi, S., Uchida, S., Kawano, S. and Sugiyama, M. (2019) Improvement of Physical and Oral Function in Community‐Dwelling Older People after a 3‐Month Long‐Term Care Prevention Program Including Physical Exercise, Oral Health Instruction, and Nutritional Guidance. Clinical and Experimental Dental Research, 5, 611-619. [Google Scholar] [CrossRef] [PubMed]
[73] Wu, X., Xu, Y., Liu, Y., Ma, A., Zhong, F., Gao, T., et al. (2024) Relationships between Oral Function, Dietary Intake and Nutritional Status in Older Adults Aged 75 Years and Above: A Cross-Sectional Study. BMC Public Health, 24, Article No. 1465. [Google Scholar] [CrossRef] [PubMed]
[74] Khairinisa, S., Kiuchi, S., Matsuyama, Y., Iwasaki, M. and Aida, J. (2025) Oral Frailty, Dental Visits, and Healthy Life Expectancy: A 6‐Year Prospective Cohort among Japanese Older Adults. Geriatrics & Gerontology International, 25, 1884-1893. [Google Scholar] [CrossRef
[75] Lin, Y.E., Zhang, X., Chen, M., Ji, Y., Shi, Y., Lin, Y., et al. (2025) Prevalence and Associated Factors of Denture Use among Older Adults Living in Rural and Urban Areas of China: A National Cross-Sectional Study. BMC Oral Health, 25, Article No. 415. [Google Scholar] [CrossRef] [PubMed]
[76] Lee, B., Choi, J., Ko, K., Lee, J. and Kim, Y. (2025) Association between Dental Care and Improvement in Long‐Term Care Dependency Levels in Korean Beneficiaries. Geriatrics & Gerontology International, 25, 911-917. [Google Scholar] [CrossRef] [PubMed]
[77] Kakei, Y., Kagimura, T., Yamamoto, Y., Osaki, T., Kajita, H., Kojima, S., et al. (2023) Tooth Loss as a Predictor of Long-Term Care Requirements in the Elderly: A Study in Kobe City, Japan. Cureus, 15, e49851. [Google Scholar] [CrossRef] [PubMed]
[78] Beltrán, V., Muñoz-Sepúlveda, F., Acevedo, C., Navarro, P., Venegas, B., Salgado, C., et al. (2024) A Rural Teledentistry Care Experience: A Geriatric Approach to Assessing Oral Health Status and Treatment Needs in Older Adults from a Mapuche Community in Chile. Frontiers in Public Health, 12, Article ID: 1356622. [Google Scholar] [CrossRef] [PubMed]
[79] Cheng, B., Ho, P., Hsu, C., Chen, F., Chen, M., Kabasawa, Y., et al. (2024) Effectiveness of the Lay Health Advisor Program on Oral Function and Quality of Life in Aboriginal Older Adults: A Randomized Controlled Trial. Journal of Oral Rehabilitation, 51, 840-850. [Google Scholar] [CrossRef] [PubMed]
[80] Huang, Y., Liu, Y., Wong, C.M., Liu, Y., Chen, J. and Leung, A.Y.M. (2025) Understanding Barriers and Facilitators to Oral Health Interventions in Community-Dwelling Older Adults with Cognitive Impairment: A Scoping Review. Archives of Gerontology and Geriatrics, 139, Article 106014. [Google Scholar] [CrossRef
[81] Bakri, N.N., Ferguson, C.A., Majeed, S., Thomson, W.M., Oda, K., Bartlett, S., et al. (2024) Workplace Oral Health Promotion Activities among Community‐Aged Care Workers: A Qualitative Exploration. Community Dentistry and Oral Epidemiology, 52, 389-397. [Google Scholar] [CrossRef] [PubMed]