基于网络药理学探讨荷叶治疗肥胖的 作用机制
Exploring the Mechanism of Lotus Leaf in Treating Obesity Based on Network Pharmacology
DOI: 10.12677/acm.2026.1651881, PDF,   
作者: 唐钦连：深圳市宝安区松岗人民医院塘下涌社区健康服务站，广东 深圳；杨胜男：深圳市宝安区松岗人民医院满京华社区健康服务站，广东 深圳
关键词: 荷叶；肥胖；网络药理学；活性成分；关键靶点；Lotus Leaf； Obesity； Network Pharmacology； Active Ingredients； Key Targets
摘要: 目的：采用网络药理学探讨荷叶治疗肥胖的作用机制。方法：检索TCMSP数据库，获取荷叶中的活性成分及其靶点，通过UniProt数据库和查找相关文献规范靶点，在GeneCards、Disgenet数据库中检索肥胖(Obesity)相关基因，运用Venn图获得两者作用的交集靶点，将其导入String数据库，导出蛋白互作关系，使用CytoscapeV3.8.2进行可视化分析获取核心靶点并构建“药物–成分–靶点–疾病”网络。借助DAVID数据库对交集靶点基因进行基因本体(GO)功能注释及KEGG通路富集。结果：筛选出荷叶活性成分共15种，对应靶点206个，与肥胖交集靶点141个，关键靶点为AKT1、TNF、MAPK1、IL6等；共获得200条GO分析条目和80条KEGG信号通路，得到以上靶点主要参与了癌症通路、肿瘤坏死因子信号通路、乙型肝炎、癌症中的蛋白多糖、PI3K-Akt信号通路等相关通路的调控。结论：本研究初步分析了荷叶治疗肥胖的作用机制，为其在临床的应用提供了理论基础。
Abstract: Objective: To explore the mechanism of action of lotus leaf in the treatment of obesity by using network pharmacology. Methods: Search the TCMSP database to obtain the active ingredients and their targets in the lotus leaf, use the UniProt database and search for related literature standard targets, search for obesity-related genes in the GeneCards and Disgenet databases, and use the Venn diagram to obtain the intersection targets of effects of both, import them into the String database, export the protein interaction relationship, use CytoscapeV3.8.2 to perform visual analysis to obtain the core targets and construct the “drug-component-target-disease” network. With the help of DAVID database, the gene ontology (GO) function annotation and KEGG pathway enrichment of the intersection target genes are carried out. Results: A total of 15 active ingredients in lotus leaves were screened, corresponding to 206 targets, and 141 targets that intersect with obesity. The key targets are AKT1, TNF, MAPK1, IL6, etc.; a total of 200 GO analysis items and 80 KEGG signals were obtained. The above targets are mainly involved in the regulation of cancer pathways, tumor necrosis factor signaling pathways, hepatitis B, proteoglycans in cancer, PI3K-Akt signaling pathways and other related pathways. Conclusion: This study preliminarily analyzed the mechanism of lotus leaf in the treatment of obesity, and provided a theoretical basis for its clinical application.
文章引用：唐钦连, 杨胜男. 基于网络药理学探讨荷叶治疗肥胖的 作用机制[J]. 临床医学进展, 2026, 16(5): 846-856. https://doi.org/10.12677/acm.2026.1651881

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