食管胃底静脉曲张个体化计算流体力学：牛顿与非牛顿模型比较
Individualized Computational Fluid Dynamics of Esophagogastric Varices: Comparison of Newtonian and Non-Newtonian Models
摘要: 目的：构建肝硬化食管胃底静脉曲张血流动力学模型，比较牛顿流体与非牛顿流体模型在不同边界条件下的模拟差异。方法：选取1例典型肝硬化食管胃底静脉曲张患者，基于Fluent软件设置5种血液粘度模型，开展计算流体力学仿真，并利用Python对门静脉主干、门静脉左支、门静脉右支、食管胃底静脉、脾静脉及肠系膜上静脉等区域的血流动力学参数进行统计分析。结果：不同血液粘度模型对门静脉系统血流动力学参数的预测存在显著影响。与各非牛顿流体模型相比，牛顿流体模型整体表现为低估TAWSS、高估OSI与RRT，并预测出更强的局部流动扰动及螺旋流结构。结论：在肝硬化门静脉高压患者的个体化血流动力学评估中，建议优先采用能够反映剪切稀化特性的非牛顿流体模型。
Abstract: Objective: To construct a hemodynamic model of esophagogastric varices in liver cirrhosis and compare the simulation differences between Newtonian and non-Newtonian fluid models under various boundary conditions. Methods: A patient with typical cirrhotic esophagogastric varices was selected. Five blood viscosity models were configured using Fluent software to perform computational fluid dynamics simulations. Hemodynamic parameters in regions including the main portal vein, left portal vein, right portal vein, esophagogastric varices, splenic vein, and superior mesenteric vein were statistically analyzed using Python. Results: Different blood viscosity models had significant effects on the prediction of hemodynamic parameters in the portal venous system. Compared with the non-Newtonian models, the Newtonian model generally underestimated TAWSS, overestimated OSI and RRT, and predicted stronger local flow disturbances and helical flow structures. Conclusion: In individualized hemodynamic assessment of patients with cirrhotic portal hypertension, it is recommended to prioritize non-Newtonian fluid models that can capture shear-thinning characteristics.
文章引用：杨红鱼, 董慧敏, 郭立. 食管胃底静脉曲张个体化计算流体力学：牛顿与非牛顿模型比较[J]. 临床医学进展, 2026, 16(5): 868-880. https://doi.org/10.12677/acm.2026.1651883

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