基于代谢重编程探讨活血化瘀药抗心肌纤维化的机制研究进展
Research Progress on Mechanism of Anti-Myocardial Fibrosis of Blood-Activating and Blood-Removing Drugs Based on Metabolic Reprogramming
DOI: 10.12677/tcm.2026.155258, PDF,   
作者: 李康杰*：黑龙江中医药大学研究生院，黑龙江 哈尔滨；陈会君#：黑龙江中医药大学附属第二医院心血管二科，黑龙江 哈尔滨
关键词: 活血化瘀；心肌纤维化；中药；代谢重编程；Activating Blood Circulation and Removing Blood Stasis； Myocardial Fibrosis； Traditional Chinese Medicine； Metabolic Reprogramming
摘要: 心肌纤维化是多种心血管疾病的共同病理结局，其特征为心脏成纤维细胞过度活化及细胞外基质异常沉积。能量代谢紊乱是心肌纤维化的核心环节，包括线粒体功能障碍、脂肪酸氧化异常、葡萄糖利用障碍及ATP生成不足等一系列变化。活血化瘀药主要通过改善线粒体功能、调控糖/脂代谢、调节关键信号通路多靶点调控心肌能量代谢，发挥抗纤维化作用。活血化瘀中药通过靶向能量代谢的多环节、多通路协同作用，改善心肌代谢稳态，为心肌纤维化临床治疗方案的优化提供参考。
Abstract: Myocardial fibrosis (MF) is a prevalent pathological consequence of various cardiovascular diseases, characterized by the excessive activation of cardiac fibroblasts and aberrant deposition of extracellular matrix. It has been established that energy metabolism disruption is the central mechanism underlying MF, encompassing mitochondrial dysfunction, abnormal fatty acid oxidation, impaired glucose utilization, and ATP depletion. Blood-activating and stasis-removing medications primarily modulate myocardial energy metabolism by enhancing mitochondrial function, regulating glucose/lipid metabolism, and influencing key signaling pathways, thereby exerting anti-fibrotic effects. Chinese herbal remedies aimed at promoting blood circulation and resolving blood stasis can enhance myocardial metabolic equilibrium through targeting multiple aspects and pathways of energy metabolism, offering insights for refining clinical treatment strategies for MF.
文章引用：李康杰, 陈会君. 基于代谢重编程探讨活血化瘀药抗心肌纤维化的机制研究进展[J]. 中医学, 2026, 15(5): 120-127. https://doi.org/10.12677/tcm.2026.155258

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