度洛西汀临床应用的研究进展
Research Advances in the Clinical Application of Duloxetine
DOI: 10.12677/hjbm.2026.163042, PDF,   
作者: 胡筹琪, 方春月, 刘起荣, 马伟杰：大理大学药学院，云南 大理；云南省第三人民医院，云南 昆明；王江涛：大理大学药学院，云南 大理；温 瑾, 杨琼晖, 钟媛媛, 华 鹏*：云南省第三人民医院，云南 昆明
关键词: 度洛西汀；临床应用；安全性；联合用药；个体化治疗；Duloxetine； Clinical Application； Safety； Combination Therapy； Personalized Treatment
摘要: 度洛西汀作为一种选择性5-羟色胺和去甲肾上腺素再摄取抑制剂，已被多个国际指南推荐用于抑郁症、广泛性焦虑障碍、纤维肌痛等的治疗。本文系统综述了度洛西汀药动学特征、作用机制、临床应用等的研究进展，重点探讨了不同适应症的剂量策略、联合治疗方案及特殊人群用药风险。通过整合最新的随机对照试验、荟萃分析及真实世界研究数据，旨在为临床决策提供全面、平衡的循证依据。
Abstract: Duloxetine, as a selective serotonin and norepinephrine reuptake inhibitor, has been recommended by multiple international guidelines for the treatment of depression, generalized anxiety disorder, fibromyalgia, and other conditions. This article systematically reviews the research progress on the pharmacokinetic characteristics, mechanism of action, and clinical applications of duloxetine, with a focus on dosage strategies for different indications, combination treatment regimens, and medication risks in special populations. By integrating the latest data from randomized controlled trials, meta-analyses, and real-world studies, it aims to provide comprehensive and balanced evidence-based support for clinical decision-making.
文章引用：胡筹琪, 王江涛, 方春月, 刘起荣, 马伟杰, 温瑾, 杨琼晖, 钟媛媛, 华鹏. 度洛西汀临床应用的研究进展[J]. 生物医学, 2026, 16(3): 399-405. https://doi.org/10.12677/hjbm.2026.163042

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