乳腺癌肝转移机制的研究进展
Advances in the Mechanisms of Breast Cancer Liver Metastasis
DOI: 10.12677/acm.2026.1651890, PDF,   
作者: 刘雅文, 陈 鑫*：重庆医科大学附属第一医院乳腺甲状腺外科，重庆
关键词: 乳腺癌；肝转移；微环境；机制；Breast Cancer； Liver Metastasis； Microenvironment； Mechanisms
摘要: 乳腺癌是女性最常见的恶性肿瘤之一，远处转移仍然是其相关死亡的主要原因。骨、肺、肝和脑是乳腺癌转移的主要靶器官。其中肝脏作为高度血供、免疫耐受和代谢活跃的器官，是乳腺癌重要且预后不良的转移部位。乳腺癌肝转移是肿瘤细胞与肝脏微环境通过多阶段发展、多因素调控及多信号通路共同作用形成的复杂动态过程。进一步理解乳腺癌细胞与肝脏微环境在乳腺癌肝转移中的相互作用，对于指导未来临床治疗至关重要。本文系统综述了乳腺癌细胞与肝脏微环境对乳腺癌肝转移的贡献，可能对未来治疗策略和预防干预带来启示。
Abstract: Breast cancer is one of the most common malignancies among women, and distant metastasis remains the leading cause of cancer-related mortality. The bone, lung, liver, and brain are the principal target organs for metastatic spread. Among these, the liver—characterized by its rich vascularization, immune-tolerant milieu, and highly active metabolic environment—represents a critical site of metastasis associated with particularly poor prognosis. Breast cancer liver metastasis is a complex and dynamic process arising from the interplay between tumor cells and the hepatic microenvironment, involving multiple sequential stages, diverse regulatory factors, and intricate signaling pathways. A deeper understanding of the interactions between breast cancer cells and the liver microenvironment in BCLM is essential for informing future therapeutic strategies. This review systematically summarizes the contributions of both breast cancer cells and the hepatic microenvironment to the development of BCLM, with the aim of providing insights into potential avenues for therapeutic intervention and preventive strategies.
文章引用：刘雅文, 陈鑫. 乳腺癌肝转移机制的研究进展[J]. 临床医学进展, 2026, 16(5): 945-954. https://doi.org/10.12677/acm.2026.1651890

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