脂质代谢及其异常在白癜风发病机制中的作用
Role of Lipid Metabolism and Its Abnormalities in Vitiligo Pathogenesis
摘要: 白癜风不仅是以黑素细胞损伤和免疫失衡为核心的色素脱失性疾病,也伴随显著的脂质代谢重塑。现有研究表明,非皮损皮肤已存在角质形成细胞分化异常、屏障脂质失衡及膜脂重构,血液中脂肪酸、溶血磷脂和鞘脂等亦发生改变。脂质代谢异常可能通过影响皮肤屏障稳态、氧化应激、免疫放大及黑素细胞存活,参与白癜风的发生、发展与转归。本文就皮肤脂质的合成与分布、主要脂质类型在白癜风中的作用及其临床干预前景进行综述,以期为白癜风机制研究与分层治疗提供新的脂质生物学视角。
Abstract: Vitiligo is not only a depigmenting disorder characterized by melanocyte damage and immune dysregulation, but also a disease accompanied by substantial lipid metabolic remodeling. Current evidence indicates that even non-lesional skin exhibits abnormal keratinocyte differentiation, impaired barrier lipids, and membrane lipid reprogramming, while circulating fatty acids, lysophospholipids, and sphingolipids are also altered. Lipid metabolic abnormalities may contribute to the initiation, progression, and outcome of vitiligo by affecting epidermal barrier homeostasis, oxidative stress, immune amplification, and melanocyte survival. This review summarizes the synthesis and distribution of skin lipids, the roles of major lipid classes in vitiligo, and the clinical prospects of lipid-targeted interventions, aiming to provide a novel lipid-biological perspective for mechanistic research and stratified therapy in vitiligo.
文章引用:尹喜辉, 仲辉. 脂质代谢及其异常在白癜风发病机制中的作用[J]. 临床医学进展, 2026, 16(5): 1097-1104. https://doi.org/10.12677/acm.2026.1651908

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