|
[1]
|
Rodrigues, M., Ezzedine, K., Hamzavi, I., Pandya, A.G. and Harris, J.E. (2017) New Discoveries in the Pathogenesis and Classification of Vitiligo. Journal of the American Academy of Dermatology, 77, 1-13. [Google Scholar] [CrossRef] [PubMed]
|
|
[2]
|
Lyu, C. and Sun, Y. (2022) Immunometabolism in the Pathogenesis of Vitiligo. Frontiers in Immunology, 13, Article ID: 1055958. [Google Scholar] [CrossRef] [PubMed]
|
|
[3]
|
Chang, W. and Ko, C. (2023) The Role of Oxidative Stress in Vitiligo: An Update on Its Pathogenesis and Therapeutic Implications. Cells, 12, Article No. 936. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
Shah, F., Patel, S., Begum, R. and Dwivedi, M. (2021) Emerging Role of Tissue Resident Memory T Cells in Vitiligo: From Pathogenesis to Therapeutics. Autoimmunity Reviews, 20, Article ID: 102868. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Feingold, K.R. (2007) Thematic Review Series: Skin Lipids. The Role of Epidermal Lipids in Cutaneous Permeability Barrier Homeostasis. Journal of Lipid Research, 48, 2531-2546. [Google Scholar] [CrossRef] [PubMed]
|
|
[6]
|
Bouwstra, J.A., Nădăban, A., Bras, W., McCabe, C., Bunge, A. and Gooris, G.S. (2023) The Skin Barrier: An Extraordinary Interface with an Exceptional Lipid Organization. Progress in Lipid Research, 92, Article ID: 101252. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
Nicolaou, A. and Kendall, A.C. (2024) Bioactive Lipids in the Skin Barrier Mediate Its Functionality in Health and Disease. Pharmacology & Therapeutics, 260, Article ID: 108681. [Google Scholar] [CrossRef] [PubMed]
|
|
[8]
|
Papaccio, F., Ottaviani, M., Truglio, M., D’Arino, A., Caputo, S., Pacifico, A., et al. (2024) Markers of Metabolic Abnormalities in Vitiligo Patients. International Journal of Molecular Sciences, 25, Article No. 10201. [Google Scholar] [CrossRef] [PubMed]
|
|
[9]
|
Lampe, M.A., Burlingame, A.L., Whitney, J., Williams, M.L., Brown, B.E., Roitman, E., et al. (1983) Human Stratum Corneum Lipids: Characterization and Regional Variations. Journal of Lipid Research, 24, 120-130. [Google Scholar] [CrossRef]
|
|
[10]
|
de Szalay, S. and Wertz, P.W. (2023) Protective Barriers Provided by the Epidermis. International Journal of Molecular Sciences, 24, Article No. 3145. [Google Scholar] [CrossRef] [PubMed]
|
|
[11]
|
Masuda-Kuroki, K. and Di Nardo, A. (2022) Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface. Biology, 11, Article No. 809. [Google Scholar] [CrossRef] [PubMed]
|
|
[12]
|
Lordan, R., Tsoupras, A., Zabetakis, I. and Demopoulos, C.A. (2019) Forty Years since the Structural Elucidation of Platelet-Activating Factor (PAF): Historical, Current, and Future Research Perspectives. Molecules, 24, Article No. 4414. [Google Scholar] [CrossRef] [PubMed]
|
|
[13]
|
Proksch, E., Brandner, J.M. and Jensen, J. (2008) The Skin: An Indispensable Barrier. Experimental Dermatology, 17, 1063-1072. [Google Scholar] [CrossRef] [PubMed]
|
|
[14]
|
Pike, L.J. (2006) Rafts Defined: A Report on the Keystone Symposium on Lipid Rafts and Cell Function. Journal of Lipid Research, 47, 1597-1598. [Google Scholar] [CrossRef] [PubMed]
|
|
[15]
|
Lin, M. and Khnykin, D. (2014) Fatty Acid Transporters in Skin Development, Function and Disease. Biochimica et Biophysica Acta (BBA)—Molecular and Cell Biology of Lipids, 1841, 362-368. [Google Scholar] [CrossRef] [PubMed]
|
|
[16]
|
Ye, Z., Chen, J., Du, P., Ni, Q., Li, B., Zhang, Z., et al. (2022) Metabolomics Signature and Potential Application of Serum Polyunsaturated Fatty Acids Metabolism in Patients with Vitiligo. Frontiers in Immunology, 13, Article ID: 839167. [Google Scholar] [CrossRef] [PubMed]
|
|
[17]
|
Ataş, H. and Gönül, M. (2017) Increased Risk of Metabolic Syndrome in Patients with Vitiligo. Balkan Medical Journal, 34, 219-225. [Google Scholar] [CrossRef] [PubMed]
|
|
[18]
|
Dailami, K.N., Hosseini, A., Rokni, G.R., et al. (2020) Efficacy of Topical Latanoprost in the Treatment of Eyelid Vitiligo: A Randomized, Double‐Blind Clinical Trial Study. Dermatologic Therapy, 33, e13175. [Google Scholar] [CrossRef] [PubMed]
|
|
[19]
|
Liang, L., Li, Y., Tian, X., Zhou, J. and Zhong, L. (2019) Comprehensive Lipidomic, Metabolomic and Proteomic Profiling Reveals the Role of Immune System in Vitiligo. Clinical and Experimental Dermatology, 44, e216-e223. [Google Scholar] [CrossRef] [PubMed]
|
|
[20]
|
Ryborg, A.K., Johansen, C., Iversen, L. and Kragballe, K. (2004) Lysophosphatidylcholine Induces Keratinocyte Differentiation and Upregulation of AP-1-and NF-kappaB DNA-Binding Activity. Acta Dermato-Venereologica, 84, 433-438. [Google Scholar] [CrossRef] [PubMed]
|
|
[21]
|
Scott, G.A., Jacobs, S.E. and Pentland, A.P. (2006) sPLA2-X Stimulates Cutaneous Melanocyte Dendricity and Pigmentation through a Lysophosphatidylcholine-Dependent Mechanism. Journal of Investigative Dermatology, 126, 855-861. [Google Scholar] [CrossRef] [PubMed]
|
|
[22]
|
Wong, B.H., Mishra, K., Chin, C.F., Galam, D.L.A., Tan, B.C., Ding, M., et al. (2026) Mfsd2a Is Important for Maintaining Epidermal Homeostasis. Proceedings of the National Academy of Sciences, 123, e2531159123. [Google Scholar] [CrossRef]
|
|
[23]
|
Paradies, G., Paradies, V., Ruggiero, F.M. and Petrosillo, G. (2019) Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects. Cells, 8, Article No. 728. [Google Scholar] [CrossRef] [PubMed]
|
|
[24]
|
Wu, X., Jin, S., Yang, Y., Lu, X., Dai, X., Xu, Z., et al. (2022) Altered Expression of Ferroptosis Markers and Iron Metabolism Reveals a Potential Role of Ferroptosis in Vitiligo. Pigment Cell & Melanoma Research, 35, 328-341. [Google Scholar] [CrossRef] [PubMed]
|
|
[25]
|
Yang, M., Li, X., Li, H., Zhang, X., Liu, X. and Song, Y. (2021) Baicalein Inhibits RLS3-Induced Ferroptosis in Melanocytes. Biochemical and Biophysical Research Communications, 561, 65-72. [Google Scholar] [CrossRef] [PubMed]
|
|
[26]
|
Zhao, C., Wang, D., Wang, X., Mao, Y., Xu, Z., Sun, Y., et al. (2020) Down‐Regulation of Exosomal miR-200c Derived from Keratinocytes in Vitiligo Lesions Suppresses Melanogenesis. Journal of Cellular and Molecular Medicine, 24, 12164-12175. [Google Scholar] [CrossRef] [PubMed]
|
|
[27]
|
Li, D., Zhou, T., She, Q., Nie, X., Liu, Z., Pan, R., et al. (2022) Circulating Exosomal miR-493-3p Affects Melanocyte Survival and Function by Regulating Epidermal Dopamine Concentration in Segmental Vitiligo. Journal of Investigative Dermatology, 142, 3262-3273.e11. [Google Scholar] [CrossRef] [PubMed]
|
|
[28]
|
li, W., Pang, Y., He, Q., Song, Z., Xie, X., Zeng, J., et al. (2024) Exosome-Derived microRNAs: Emerging Players in Vitiligo. Frontiers in Immunology, 15, Article ID: 1419660. [Google Scholar] [CrossRef] [PubMed]
|
|
[29]
|
Kovacs, D., Bastonini, E., Briganti, S., Ottaviani, M., D’Arino, A., Truglio, M., et al. (2022) Altered Epidermal Proliferation, Differentiation, and Lipid Composition: Novel Key Elements in the Vitiligo Puzzle. Science Advances, 8, eabn9299. [Google Scholar] [CrossRef] [PubMed]
|
|
[30]
|
Vanderweil, S.G., Amano, S., Ko, W., Richmond, J.M., Kelley, M., Senna, M.M., et al. (2017) A Double-Blind, Placebo-Controlled, Phase-II Clinical Trial to Evaluate Oral Simvastatin as a Treatment for Vitiligo. Journal of the American Academy of Dermatology, 76, 150-151.e3. [Google Scholar] [CrossRef] [PubMed]
|
|
[31]
|
Nguyen, S., Chuah, S.Y., Fontas, E., Khemis, A., Jhingan, A., Thng, S.T.G., et al. (2018) Atorvastatin in Combination with Narrowband UV-B in Adult Patients with Active Vitiligo: A Randomized Clinical Trial. JAMA Dermatology, 154, 725-726. [Google Scholar] [CrossRef] [PubMed]
|
|
[32]
|
Shaker, E.S.E., Allam, S.H., Mabrouk, M.M., Elgharbawy, N.M. and Salaam, S.F.A. (2022) Simvastatin and Non-Segmental Vitiligo: A New Potential Treatment Option? Dermatologic Therapy, 35, e15969. [Google Scholar] [CrossRef] [PubMed]
|
|
[33]
|
Niezgoda, A., Winnicki, A., Krysiński, J., Niezgoda, P., Nowowiejska, L. and Czajkowski, R. (2024) Topical Application of Simvastatin Acid Sodium Salt and Atorvastatin Calcium Salt in Vitiligo Patients. Results of the Randomized, Double-Blind EVRAAS Pilot Study. Scientific Reports, 14, Article No. 14612. [Google Scholar] [CrossRef] [PubMed]
|
|
[34]
|
Agarwal, P., Rashighi, M., Essien, K.I., Richmond, J.M., Randall, L., Pazoki-Toroudi, H., et al. (2015) Simvastatin Prevents and Reverses Depigmentation in a Mouse Model of Vitiligo. Journal of Investigative Dermatology, 135, 1080-1088. [Google Scholar] [CrossRef] [PubMed]
|
|
[35]
|
Pratchyapruit, W., Kikuchi, K., Gritiyarangasan, P., Aiba, S. and Tagami, H. (2007) Functional Analyses of the Eyelid Skin Constituting the Most Soft and Smooth Area on the Face: Contribution of Its Remarkably Large Superficial Corneocytes to Effective Water‐Holding Capacity of the Stratum Corneum. Skin Research and Technology, 13, 169-175. [Google Scholar] [CrossRef] [PubMed]
|
|
[36]
|
Kleesz, P., Darlenski, R. and Fluhr, J.W. (2012) Full-Body Skin Mapping for Six Biophysical Parameters: Baseline Values at 16 Anatomical Sites in 125 Human Subjects. Skin Pharmacology and Physiology, 25, 25-33. [Google Scholar] [CrossRef] [PubMed]
|
|
[37]
|
DeLeo, V., Scheide, S., Meshulam, J., Hanson, D. and Cardullo, A. (1988) Ultraviolet Radiation Alters Choline Phospholipid Metabolism in Human Keratinocytes. Journal of Investigative Dermatology, 91, 303-308. [Google Scholar] [CrossRef] [PubMed]
|
|
[38]
|
Gauthier, Y., Cario-Andre, M., Lepreux, S., Pain, C. and Taieb, A. (2003) Melanocyte Detachment after Skin Friction in Non Lesional Skin of Patients with Generalized Vitiligo. British Journal of Dermatology, 148, 95-101. [Google Scholar] [CrossRef] [PubMed]
|
|
[39]
|
Boukhedouni, N., Martins, C., Darrigade, A., Drullion, C., Rambert, J., Barrault, C., et al. (2020) Type-1 Cytokines Regulate Matrix Metalloprotease-9 Production and E-Cadherin Disruption to Promote Melanocyte Loss in Vitiligo. JCI Insight, 5, e133772. [Google Scholar] [CrossRef] [PubMed]
|