氧含量与青少年特发性脊柱侧凸的关联及其 潜在机制研究进展

Advances in Research on the Association Between Oxygen Content and Adolescent Idiopathic Scoliosis and Its Potential Mechanisms

摘要: 脊柱侧凸是一种复杂的三维脊柱畸形，除冠状面侧弯外，还涉及矢状面与轴向旋转异常，其发病率近年来呈显著上升趋势。现有治疗策略多聚焦于脊柱畸形的力学矫正，而针对疾病发生发展的分子与细胞机制的干预手段仍较为有限，这凸显了探究脊柱侧凸发病机制的紧迫性。在这一领域的研究中，环境因素在AIS发生发展中的作用受到关注。通过对过去十年文献的系统检索和整理，本文详尽概述了氧含量与脊柱侧凸发生发展的最新研究进展，旨在为深化理解脊柱侧凸的病理机制并探寻潜在治疗策略提供有力的理论依据。

Abstract: Scoliosis is a complex three-dimensional spinal deformity, involving not only coronal plane curvature but also abnormalities in the sagittal plane and axial rotation. The incidence of scoliosis has significantly increased in recent years. Current treatment strategies primarily focus on mechanical correction of the spinal deformity, while interventions targeting the molecular and cellular mechanisms underlying disease onset and progression remain limited. This highlights the urgency of investigating the pathogenesis of scoliosis. In this field of research, environmental factors have attracted attention for their potential role in the development and progression of Adolescent Idiopathic Scoliosis (AIS). Through a systematic review of the literature over the past decade, this paper provides a comprehensive overview of the latest research on the relationship between oxygen levels and the occurrence and progression of scoliosis. The aim is to offer a strong theoretical foundation for deepening the understanding of the pathological mechanisms of scoliosis and exploring potential therapeutic strategies.