中西医治疗痛风的研究进展

Research Progress on the Treatment of Gout with Traditional Chinese Medicine and Western Medicine

摘要: 痛风是一种发病率在全球范围内呈逐年上升趋势的慢性代谢性疾病，因其病情迁延难愈、症状反复发作，给患者带来极大痛苦。该病不仅累及关节，导致剧烈疼痛与畸形，还可引发眼部、肾脏及心脑血管等多系统病变，造成继发性损害，严重影响患者生活质量。本文通过系统梳理国内外关于痛风发病机制与治疗策略的相关文献，从中医病因病机、西医发病原理、中医治疗、西医治疗以及中西医结合治疗五个维度进行综述。旨在对中西医的相关研究现状做出评述，对未来研究进行展望。综上所述，中西医在痛风的认识与治疗上各有侧重，亦存在互补空间。未来研究应进一步深化中西医结合的机制探讨，推动个体化治疗方案的优化，以期实现更佳的临床疗效。

Abstract: Gout is a chronic metabolic disorder and its global prevalence has demonstrated a marked annual increase. The disease is clinically distinguished by a protracted clinical course punctuated by recurrent acute flares, which not only impose substantial physical and psychological distress on patients but also predispose them to pathological involvement extending beyond the articular system. Manifestations frequently include severe arthralgia and progressive joint deformity, alongside secondary damage to ocular, renal, and cardiovascular systems, cumulatively resulting in a significant deterioration in patient quality of life. This article presents a systematic review of the relevant literature concerning the pathogenesis and therapeutic strategies for gout. The review is comprehensively structured across five principal dimensions: the etiology and pathogenesis as delineated by Traditional Chinese Medicine (TCM), the pathogenic mechanisms defined by Western medicine, TCM therapeutic modalities, Western medical treatments, and integrated therapeutic approaches. The objective of this review is to critically evaluate the current state of research within both medical paradigms and to propose directions for future scholarly inquiry. It is concluded that TCM and Western medicine each offer distinct perspectives and possess inherent therapeutic strengths in the understanding and clinical management of gout, revealing a significant potential for complementarity. Future research endeavors should focus on intensifying the mechanistic exploration of integrated treatment modalities and advancing the optimization of personalized therapeutic regimens, with the ultimate objective of achieving superior clinical efficacy.