地黄多糖治疗溃疡性结肠炎的研究进展
Research Progress on the Treatment of Ulcerative Colitis with Rehmannia Polysaccharides
DOI: 10.12677/acm.2026.1651929, PDF,    科研立项经费支持
作者: 王思淼, 汤 伟, 贾东翰, 高一乔*：河南医药大学药学院，河南 新乡；宋相仕*：河南医药大学第四临床学院，河南 新乡
关键词: 溃疡性结肠炎；地黄多糖；肠道菌群；作用机制；Ulcerative Colitis； Rehmannia Polysaccharides； Gut Microbiota； Mechanism of Action
摘要: 地黄为玄参科植物地黄的干燥块根，依炮制工艺分为鲜地黄、生地黄、熟地黄，是中医治疗阴虚内热类疾病的常用药材。地黄多糖作为地黄的核心活性成分，兼具抗炎、抗氧化、调节肠道菌群、促进短链脂肪酸生成、修复肠黏膜屏障等药理作用，可用于缓解溃疡性结肠炎的病理损伤。然而，目前针对地黄治疗溃疡性结肠炎的作用机制相关报道仍相对较少。本文通过对地黄多糖的提取纯化工艺、结构特征及治疗溃疡性结肠炎的作用机制进行综述，以期通过梳理现有研究为地黄多糖的进一步开发应用及机制深入探究提供参考。
Abstract: Rehmannia is the dried root of the plant Rehmannia glutinosa, which is classified into fresh rehmannia, raw rehmannia, and cooked rehmannia based on the processing method. It is a commonly used medicinal material in traditional Chinese medicine for treating diseases related to yin deficiency and internal heat. Rehmannia polysaccharides, as the core active component of rehmannia, possess pharmacological effects such as anti-inflammation, antioxidation, regulation of intestinal flora, promotion of short-chain fatty acid production, and repair of intestinal mucosal barrier, and can be used to alleviate the pathological damage of ulcerative colitis. However, there are still relatively few reports on the mechanism of action of rehmannia in treating ulcerative colitis. This article reviews the extraction and purification process, structural characteristics, and therapeutic mechanism of rehmannia polysaccharides, with the aim of providing references for the further development and application of rehmannia polysaccharides and in-depth exploration of its mechanism.
文章引用：王思淼, 汤伟, 贾东翰, 宋相仕, 高一乔. 地黄多糖治疗溃疡性结肠炎的研究进展[J]. 临床医学进展, 2026, 16(5): 1284-1293. https://doi.org/10.12677/acm.2026.1651929

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