睡眠质量对围绝经期生活质量的影响:幸福感的中介作用
The Impact of Sleep Quality on Health-Related Quality of Life in Perimenopausal Women: The Mediating Role of Well-Being
DOI: 10.12677/acm.2026.1651936, PDF,   
作者: 姜沈佳, 罗芙瑶:重庆医科大学公共卫生学院,重庆;徐晓阳:重庆医科大学附属第二医院体检中心,重庆;范 尧*:重庆医科大学公共卫生学院,重庆;重庆医科大学附属第三医院妇产中心,重庆
关键词: 睡眠质量幸福感健康相关生活质量围绝经期女性中介分析Sleep Quality Well-Being Health-Related Quality of Life Perimenopausal Women Mediation Analysis
摘要: 目的:探讨幸福感在围绝经期女性睡眠质量与健康相关生活质量(HRQoL)之间的中介作用,为制定围绝经期女性生活质量管理策略提供参考依据。方法:采用便利抽样法,选取2024年10月至2025年5月重庆市某三甲医院体检中心468名45~55岁围绝经期女性为研究对象。使用匹兹堡睡眠质量指数(PSQI)、PERMA幸福感量表及SF-12生活质量量表进行调查。通过Spearman相关分析及结构方程模型分析变量间关系,并采用Bootstrap法检验中介效应。结果:围绝经期女性整体睡眠质量处于中等偏差水平。相关分析显示,睡眠质量与健康相关生活质量(r = −0.518)及幸福感(r = −0.537)均呈显著负相关,幸福感与健康相关生活质量呈显著正相关(r = 0.665, P < 0.05)。结构方程模型结果表明,睡眠质量不仅直接影响健康相关生活质量(效应值为−0.158),还可通过幸福感产生显著间接影响(效应值为−0.362),中介效应占总效应的69.62%。结论:围绝经期女性普遍存在睡眠问题,睡眠质量、幸福感与健康相关生活质量密切相关。幸福感在睡眠质量与健康相关生活质量之间发挥重要中介作用。改善睡眠质量并提升幸福感,有助于综合提高围绝经期女性的生活质量。
Abstract: Objective: This paper aims to explore the mediating role of well-being in the relationship between sleep quality and health-related quality of life (HRQoL) among perimenopausal women, and to provide a reference for developing management strategies to improve their quality of life. Methods: A convenience sampling method was used to recruit 468 perimenopausal women aged 45~55 years who attended a health examination center of a tertiary hospital in Chongqing from October 2024 to May 2025. Data were collected using the Pittsburgh Sleep Quality Index (PSQI), the PERMA-Profiler Scale, and the 12-Item Short Form Health Survey (SF-12). Spearman correlation analysis and structural equation modeling were conducted to examine the relationships among variables, and the Bootstrap method was applied to test the mediating effect. Results: The overall sleep quality of perimenopausal women was at a moderate-to-poor level. Correlation analysis showed that sleep quality was significantly negatively correlated with HRQoL (r = −0.518) and well-being (r = −0.537), while well-being was significantly positively correlated with HRQoL (r = 0.665, P < 0.05). Structural equation modeling indicated that sleep quality not only had a direct effect on HRQoL (−0.158), but also exerted a significant indirect effect through well-being (−0.362), with the mediating effect accounting for 69.62% of the total effect. Conclusion: Sleep problems are common among perimenopausal women, and sleep quality, well-being, and HRQoL are closely related. Well-being plays a significant mediating role between sleep quality and HRQoL. Improving sleep quality and enhancing well-being may help to comprehensively improve the quality of life of perimenopausal women.
文章引用:姜沈佳, 罗芙瑶, 徐晓阳, 范尧. 睡眠质量对围绝经期生活质量的影响:幸福感的中介作用[J]. 临床医学进展, 2026, 16(5): 1348-1358. https://doi.org/10.12677/acm.2026.1651936

参考文献

[1] Fang, Y., Liu, F., Zhang, X., Chen, L., Liu, Y., Yang, L., et al. (2024) Mapping Global Prevalence of Menopausal Symptoms among Middle-Aged Women: A Systematic Review and Meta-Analysis. BMC Public Health, 24, Article No. 1767. [Google Scholar] [CrossRef] [PubMed]
[2] Moline, M.L., Broch, L., Zak, R. and Gross, V. (2003) Sleep in Women across the Life Cycle from Adulthood through Menopause. Sleep Medicine Reviews, 7, 155-177. [Google Scholar] [CrossRef] [PubMed]
[3] Harrington, Y.A., Parisi, J.M., Duan, D., Rojo-Wissar, D.M., Holingue, C. and Spira, A.P. (2022) Sex Hormones, Sleep, and Memory: Interrelationships across the Adult Female Lifespan. Frontiers in Aging Neuroscience, 14, Article 800278. [Google Scholar] [CrossRef] [PubMed]
[4] Su, P. and He, M. (2023) Relationship between Sleep Quality and Subjective Well-Being: Resilience as a Mediator and Belief in a Just World as a Moderator. Frontiers in Psychiatry, 14, Article 1297256. [Google Scholar] [CrossRef] [PubMed]
[5] Guo, S.Q., Wang, L.Q., Tu, J.F., et al. (2025) Factors Associated with Depression, Anxiety, and Sleep Disturbance among Patients with Moderate-to-Severe Chronic Pain: A Multicenter Cross-Sectional Study. Journal of Pain Research, 18, 6791-6805. [Google Scholar] [CrossRef
[6] Li, X., Ren, Z., Ji, T., Shi, H., Zhao, H., He, M., et al. (2022) Associations of Sleep Quality, Anxiety Symptoms and Social Support with Subjective Well-Being among Chinese Perimenopausal Women. Journal of Affective Disorders, 302, 66-73. [Google Scholar] [CrossRef] [PubMed]
[7] WHO (1995) The World Health Organization Quality of Life assessment (WHOQOL): Position Paper from the World Health Organization. Social Science & Medicine, 41, 1403-1409.
[8] Saadeh, M., Welmer, A.K., Dekhtyar, S., et al. (2020) The Role of Psychological and Social Well-Being on Physical Function Trajectories in Older Adults. The Journals of Gerontology: Series A, 75, 1579-1585. [Google Scholar] [CrossRef] [PubMed]
[9] Zhu, C., Lian, Z., Huang, Y., Zhong, Q. and Wang, J. (2023) Association between Subjective Well-Being and All-Cause Mortality among Older Adults in China. BMC Psychiatry, 23, Article No. 624. [Google Scholar] [CrossRef] [PubMed]
[10] Hess, R., Thurston, R.C., Hays, R.D., Chang, C.H., Dillon, S.N., Ness, R.B., et al. (2012) The Impact of Menopause on Health-Related Quality of Life: Results from the STRIDE Longitudinal Study. Quality of Life Research, 21, 535-544. [Google Scholar] [CrossRef] [PubMed]
[11] Buysse, D.J., Reynolds, C.F., Monk, T.H., Berman, S.R. and Kupfer, D.J. (1989) The Pittsburgh Sleep Quality Index: A New Instrument for Psychiatric Practice and Research. Psychiatry Research, 28, 193-213. [Google Scholar] [CrossRef] [PubMed]
[12] Butler, J. and Kern, M.L. (2016) The PERMA-Profiler: A Brief Multidimensional Measure of Flourishing. International Journal of Wellbeing, 6, 1-48. [Google Scholar] [CrossRef
[13] Ware, J.E., Keller, S.D. and Kosinski, M. (1995) SF-12: How to Score the SF-12 Physical and Mental Health Summary Scales. Health Institute, New England Medical Center.
[14] McDonald, R.P. and Ho, M.R. (2002) Principles and Practice in Reporting Structural Equation Analyses. Psychological Methods, 7, 64-82. [Google Scholar] [CrossRef] [PubMed]
[15] Hwang, J.H., Lee, K., Choi, E., Cho, H.N., Park, B., Rhee, Y., et al. (2021) Sleep Quality and Associated Factors in Premenopausal, Perimenopausal, and Postmenopausal Women in Korea: Findings from the K-Stori 2016. Nature and Science of Sleep, 13, 1137-1145. [Google Scholar] [CrossRef] [PubMed]
[16] Park, S.K., Jung, J.Y., Oh, C., McIntyre, R.S. and Lee, J. (2018) Association between Sleep Duration, Quality and Body Mass Index in the Korean Population. Journal of Clinical Sleep Medicine, 14, 1353-1360. [Google Scholar] [CrossRef] [PubMed]
[17] Saeed, H.A., Mohsen, A.H., Alqayem, A.T., Hasan, S.H., Hasan, M.M. and Alzeera, H.A. (2024) Sleep Quality and Its Contributing Factors among Patients with Obesity: A Cross-Sectional Study. Cureus, 16, e74038. [Google Scholar] [CrossRef] [PubMed]
[18] Isono, S. (2012) Obesity and Obstructive Sleep Apnoea: Mechanisms for Increased Collapsibility of the Passive Pharyngeal Airway. Respirology, 17, 32-42. [Google Scholar] [CrossRef] [PubMed]
[19] Sun, Y., Laksono, I., Selvanathan, J., Saripella, A., Nagappa, M., Pham, C., et al. (2021) Prevalence of Sleep Disturbances in Patients with Chronic Non-Cancer Pain: A Systematic Review and Meta-Analysis. Sleep Medicine Reviews, 57, Article 101467. [Google Scholar] [CrossRef] [PubMed]
[20] Aldabayan, Y.S., Alqahtani, J.S., Al Rajeh, A.M., Abdelhafez, A.I., Siraj, R.A., Thirunavukkarasu, V., et al. (2022) Prevalence and Predictors of Sleep Disturbance, Anxiety and Depression among Patients with Chronic Respiratory Diseases. International Journal of Environmental Research and Public Health, 19, Article 12819. [Google Scholar] [CrossRef] [PubMed]
[21] Prather, A.A., Puterman, E., Epel, E.S. and Dhabhar, F.S. (2014) Poor Sleep Quality Potentiates Stress-Induced Cytokine Reactivity in Postmenopausal Women with High Visceral Abdominal Adiposity. Brain, Behavior, and Immunity, 35, 155-162. [Google Scholar] [CrossRef] [PubMed]
[22] de Menezes Júnior, L.A.A., Almeida, F.M., Barbosa, B.C.R., Machado-Coelho, G.L.L. and Meireles, A.L. (2025) Chronic Non-Communicable Diseases and Poor Sleep Quality during the COVID-19 Pandemic: An Analysis of Mediation by Anxiety and Depression Symptoms. Sleep Science and Practice, 9, Article No. 4. [Google Scholar] [CrossRef
[23] Sarıarslan, H.A., Gulhan, Y.B., Unalan, D., Basturk, M. and Delibas, S. (2015) The Relationship of Sleep Problems to Life Quality and Depression. Neurosciences, 20, 236-242. [Google Scholar] [CrossRef] [PubMed]
[24] Sella, E., Miola, L., Toffalini, E. and Borella, E. (2023) The Relationship between Sleep Quality and Quality of Life in Aging: A Systematic Review and Meta-Analysis. Health Psychology Review, 17, 169-191. [Google Scholar] [CrossRef] [PubMed]
[25] Varma, P., Burge, M., Meaklim, H., Junge, M. and Jackson, M.L. (2021) Poor Sleep Quality and Its Relationship with Individual Characteristics, Personal Experiences and Mental Health during the COVID-19 Pandemic. International Journal of Environmental Research and Public Health, 18, Article 6030. [Google Scholar] [CrossRef] [PubMed]
[26] Du, J., Li, J., Liang, H., Wang, F., Lin, Y. and Shao, B. (2024) State of Mental Health, Sleep Status, and the Interaction with Health-Related Quality of Life in HIV-Infected Chinese Patients during the COVID-19 Pandemic. BMC Public Health, 24, Article No. 1445. [Google Scholar] [CrossRef] [PubMed]
[27] Zang, W., Liu, N., Wu, J., Wu, J., Guo, B., Xiao, N., et al. (2025) From Quality of Life to Sleep Quality in Chinese College Students: Stress and Anxiety as Sequential Mediators with Nonlinear Effects via Machine Learning. Journal of Affective Disorders, 389, Article 119679. [Google Scholar] [CrossRef] [PubMed]
[28] Khazaie, H., Mohammadi, H., Rezaei, M. and Faghihi, F. (2019) Hypothalamic-Pituitary-Gonadal Activity in Paradoxical and Psychophysiological Insomnia. Journal of Medical Signals & Sensors, 9, 59-67. [Google Scholar] [CrossRef] [PubMed]
[29] Cohn, A.Y., Grant, L.K., Nathan, M.D., Wiley, A., Abramson, M., Harder, J.A., et al. (2023) Effects of Sleep Fragmentation and Estradiol Decline on Cortisol in a Human Experimental Model of Menopause. The Journal of Clinical Endocrinology & Metabolism, 108, e1347-e1357. [Google Scholar] [CrossRef] [PubMed]
[30] Fredrickson, B.L. (2004) The Broaden-and-Build Theory of Positive Emotions. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 359, 1367-1377. [Google Scholar] [CrossRef] [PubMed]
[31] Graham-Engeland, J.E., Sin, N.L., Smyth, J.M., Jones, D.R., Knight, E.L., Sliwinski, M.J., et al. (2018) Negative and Positive Affect as Predictors of Inflammation: Timing Matters. Brain, Behavior, and Immunity, 74, 222-230. [Google Scholar] [CrossRef] [PubMed]
[32] Zuccarella-Hackl, C., Princip, M., Sivakumar, S. and von Känel, R. (2024) Positive Psychological Well-Being and Cardiovascular Health. Frontiers in Psychiatry, 15, Article 1443978. [Google Scholar] [CrossRef] [PubMed]
[33] Andreasson, A.N., Szulkin, R., Undén, A., von Essen, J., Nilsson, L. and Lekander, M. (2013) Inflammation and Positive Affect Are Associated with Subjective Health in Women of the General Population. Journal of Health Psychology, 18, 311-320. [Google Scholar] [CrossRef] [PubMed]
[34] Weinberg, M.K., Noble, J.M. and Hammond, T.G. (2016) Sleep Well Feel Well: An Investigation into the Protective Value of Sleep Quality on Subjective Well‐Being. Australian Journal of Psychology, 68, 91-97. [Google Scholar] [CrossRef
[35] Ren, X.Q., Zhao, G.M., Fang, S.W., et al. (2024) Mediating Roles of Activities of Daily Living and Depression on the Relationship between Sleep Quality and Health-Related Quality of Life. Scientific Reports, 14, Article No. 14057. [Google Scholar] [CrossRef] [PubMed]
[36] Yuan, Y., Li, J., Jing, Z., Yu, C., Zhao, D., Hao, W., et al. (2020) The Role of Mental Health and Physical Activity in the Association between Sleep Quality and Quality of Life among Rural Elderly in China: A Moderated Mediation Model. Journal of Affective Disorders, 273, 462-467. [Google Scholar] [CrossRef] [PubMed]