膝三针配合独活寄生汤治疗膝骨关节炎临床疗效观察

Observation of the Clinical Efficacy of Three Knee Injections Combined with Live Parasitic Soup in the Treatment of Knee Osteoarthritis

摘要: 目的：对肝肾亏虚型膝骨关节炎(KOA)的临床疗效进行膝三针配合独活寄生汤的观察，为临床提供安全有效的中医治疗方案，充实此类疾病的中医临床治疗思路与实践依据。方法：随机将60名肝肾亏虚型KOA患者，按纳入标准分成观察组和对照组，每组30人。对照组口服美罗昔康片7.5 mg，每日1次；观察组膝三针针刺配合独活寄生汤内服，两组患者均连续接受10天的治疗。分别采用视觉模拟评分法(VAS)、西安大略和麦克马斯特大学骨关节炎指数量表(WOMAC)、中医证候积分评估疼痛、关节功能和中医证候改善等方法进行治疗前和治疗10天后的改善情况，同时对不良反应进行记录。结果：治疗10天后，两组患者的VAS疼痛评分、WOMAC膝关节功能评分及中医证候评分，相较于治疗前均呈现显著降低趋势，差异具备统计学意义(P < 0.05)；观察组指标改善程度优于对照组(P < 0.05)；观察组的总有效率为93.33%，比对照组的73.33% (P < 0.05)，有效率明显提高。两组不良反应发生率的差异没有统计学意义(P > 0.05)。结语：膝三针配伍独活寄生汤治疗肝肾亏虚型膝骨关节炎(KOA)，可有效减轻患者关节疼痛程度，显著改善关节活动功能与相关中医证候，临床治疗效果确切，且治疗期间安全性良好，无明显不良反应，具备较高的临床实用性与推广价值。

Abstract: Objective: To treat renal and hepatic knee osteoarthritis. The clinical efficacy of KOA is observed by three knee injections together with a living parasite soup, providing a safe and effective traditional Chinese medicine treatment plan for the clinic, and enhancing the basis of traditional Chinese clinical treatment ideas and practices for such diseases. Methods: 60 patients with KOA of liver and kidney deficiency were randomly divided into an observation group and a control group according to the inclusion criteria, 30 patients in each group. The control group was given Meloxicam 7.5 mg once a day. In the observational group, three knee injections was given in combination with live parasitic soup. Patients in both groups received treatment for 10 consecutive days. Visual analog score (VAS), Western Ontario and McMaster University Osteoarthritis Index Scale (WOMAC), TCM syndrome score to assess pain, joint function and improvement of TCM syndrome before and after 10 days of treatment, and record the negative response. Results: After 10 days of treatment, the VAS pain score, the WOMAC knee function score and the TCM symptom score in both groups showed a significant decrease compared to the pre-treatment differences (P < 0.05). The improvement degree of the observation group was better than that of the control group (P < 0.05). The total effective rate in the observation group was 93.33%, which was higher than that in the control group (73.33%, P < 0.05). There was no significant difference between the two groups (P > 0.05). Conclusion: The treatment of knee osteoarthritis (KOA) of liver and kidney deficiency type with living parasite soup combined with three knee injections, It can effectively reduce the degree of joint pain in patients, significantly improve joint activity function and related traditional Chinese medicine symptoms, clinical treatment effect is precise, and safety is good during treatment, there are no obvious adverse reactions, and has high clinical use and promotional value.