中医寒热治法方药治疗溃疡性结肠炎的研究进展
Research Progress on Chinese Herbal Formulas and Medicinals Based on Cold-Heat Therapeutic Principles for Ulcerative Colitis
DOI: 10.12677/tcm.2026.155272, PDF,   
作者: 雎 米：成都中医药大学临床医学院，四川 成都；周 策*：成都中医药大学附属医院肛肠科，四川 成都
关键词: 寒热并用法；溃疡性结肠炎；信号通路；机制研究；Cold-Hot Combined Method； Ulcerative Colitis； Signal Pathway； Mechanism Research
摘要: UC是一种慢性炎症性肠病，其发病机制与多种信号通路的异常活化密切相关。研究发现，中医寒热并用方剂能通过调节NF-κB、MAPK、Notch、NLRP3等信号通路，减轻炎症反应，修复肠道黏膜损伤，从而有效控制UC疾病的进展。本文探讨了寒热并用方剂在治疗UC疾病中的分子机制，以及寒热配伍的协同治疗效应，以期通过探讨寒热并用法的临床作用机制与药效靶点，以求将寒热并用方药更好地运用于UC的临床治疗当中，寒热并用法可能为未来治疗标本同病、虚实错杂等疑难杂症提供新的思路。
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease whose pathogenesis is closely associated with the aberrant activation of multiple signaling pathways. Research has shown that Chinese herbal formulas combining cold and hot properties can attenuate inflammation and repair intestinal mucosal damage by modulating signaling pathways such as NF-κB, MAPK, Notch, and NLRP3, thereby effectively controlling the progression of UC. This article discusses the molecular mechanisms of cold-hot combined method in treating UC and the synergistic therapeutic effects of cold-hot pairing. By exploring the clinical mechanisms and pharmacodynamic targets of this approach, we aim to facilitate the better application of cold-hot combined formulas in the clinical management of UC. The cold-hot combined method may provide a new approach for treating refractory diseases involving simultaneous root and branch manifestations or intermingled deficiency and excess.
文章引用：雎米, 周策. 中医寒热治法方药治疗溃疡性结肠炎的研究进展[J]. 中医学, 2026, 15(5): 220-229. https://doi.org/10.12677/tcm.2026.155272

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