金属有机骨架材料的临床应用进展
Research Progress on Clinical Applications of Metal-Organic Frameworks
DOI: 10.12677/acm.2026.1651962, PDF,    科研立项经费支持
作者: 练 达*, 侯代鑫, 刘鲲鹏, 姜 昊, 何梓睿, 张倍宁:佳木斯大学临床医学院,黑龙江 佳木斯;赵雨轩:佳木斯大学材料科学与工程学院,黑龙江 佳木斯;谢鹏宇#:佳木斯大学基础医学院,黑龙江 佳木斯
关键词: 金属有机骨架材料临床应用临床医学材料科学Metal-Organic Frameworks Clinical Application Clinical Medicine Material Sciences
摘要: 金属有机骨架材料(Metal-organic frameworks, MOFs)是由金属离子或团簇与有机配体通过配位键连接形成的新型多孔杂化材料,以高孔隙率、可定制化结构、多重刺激响应性及易功能化修饰为核心特性。其兼具疾病精准诊断与靶向治疗的多重临床价值,突破了传统医用载体载药量低、药物控释效果差、靶向性不足的局限,同时可实现诊疗一体化功能的整合与生物相容性的灵活优化。本文综述了MOFs在临床医学领域的研究进展,重点分析了其核心特性、临床应用优势和局限性等,为临床疾病个体化精准诊疗方案的优化及新型医用载体的研发提供参考。
Abstract: Metal-organic frameworks (MOFs) are a novel class of porous hybrid materials self-assembled from metal ions or clusters and organic ligands via coordination bonds, with high porosity, tailorable structure, multi-stimuli responsiveness, and ease of functionalization as their core characteristics. These inherent properties endow MOFs with multifaceted clinical value in both precise disease diagnosis and targeted therapy, overcoming the inherent limitations of conventional biomedical delivery vehicles, including low drug loading capacity, suboptimal controlled drug release performance, and insufficient targeting specificity. Meanwhile, MOFs enable the seamless integration of theranostic functions and flexible modulation of biocompatibility. This review summarizes the research advances of MOFs in clinical medicine, with a focus on the analysis of their core characteristics, clinical application advantages, and existing limitations, aiming to provide a reference for optimizing individualized precise diagnosis and treatment regimens for clinical diseases and the development of novel biomedical delivery carriers.
文章引用:练达, 赵雨轩, 侯代鑫, 刘鲲鹏, 姜昊, 何梓睿, 张倍宁, 谢鹏宇. 金属有机骨架材料的临床应用进展[J]. 临床医学进展, 2026, 16(5): 1595-1605. https://doi.org/10.12677/acm.2026.1651962

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