深度学习舌诊模型在消化道疾病中的应用研究进展
Research Progress on the Application of Deep Learning Tongue Diagnosis Models in Gastrointestinal Diseases
DOI: 10.12677/acm.2026.1651975, PDF,   
作者: 林映清:广西中医药大学第一临床医学院,广西 南宁;刘熙荣*:广西中医药大学第一附属医院消化内镜诊疗区,广西 南宁
关键词: 舌诊深度学习图像分析卷积神经网络Tongue Diagnosis Deep Learning Image Analysis Convolutional Neural Network
摘要: 舌诊作为中医四诊中望诊的代表手段之一,可令医者做到司外揣内,然而传统舌诊常受限于医生的经验和主观性而无法充分发挥其作用,基于深度学习构建的各类舌诊模型的出现为上消化道疾病的早期筛查和辨证施治提供了智能化支持。本文探究舌诊客观化发展历程,检索了近10年来发表的高质量研究,对舌象采集及处理、模型网络架构、模型优化等方面的进展及深度学习舌诊模型在消化道疾病中的应用研究进行了系统综述,发现现有研究多仍存在如样本量受限、多模态模型较少等不足,未来需朝着多中心、大样本、标准化采集迈进,可将舌诊模型与胃镜图像结合综合进行预测,提高智能舌诊模型的预测精度,还能进一步引入时序卷积网络(TCN)捕捉长期的舌象演变趋势,实现疗效与预后的评估,推动医学与人工智能学科交叉应用的发展。
Abstract: Tongue diagnosis, as one of the representative methods of inspection in the four diagnostic methods of traditional Chinese medicine, enables doctors to infer internal conditions from external observations. However, traditional tongue diagnosis is often limited by the doctor’s experience and subjectivity, thus failing to fully exert its potential. The emergence of various tongue diagnosis models based on deep learning has provided intelligent support for the early screening and syndrome differentiation treatment of upper gastrointestinal diseases. This paper explores the development process of objective tongue diagnosis, retrieves high-quality studies published in the past decade, and conducts a systematic review of the progress in tongue image acquisition and processing, model network architecture, model optimization, and the application research of deep learning tongue diagnosis models in digestive diseases. It is found that existing studies still have shortcomings such as limited sample size and few multimodal models. In the future, we should move towards a multi-center, large-sample, and standardized collection approach. We can combine the tongue diagnosis model with gastroscopy images for comprehensive prediction, thereby improving the prediction accuracy of the intelligent tongue diagnosis model. Additionally, we can further introduce the temporal convolutional network (TCN) to capture the long-term evolution trend of tongue conditions, enabling the assessment of therapeutic effects and prognosis, and promoting the development of interdisciplinary applications between medicine and artificial intelligence.
文章引用:林映清, 刘熙荣. 深度学习舌诊模型在消化道疾病中的应用研究进展[J]. 临床医学进展, 2026, 16(5): 1723-1731. https://doi.org/10.12677/acm.2026.1651975

参考文献

[1] Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R.L., Soerjomataram, I., et al. (2024) Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 74, 229-263. [Google Scholar] [CrossRef] [PubMed]
[2] Arnold, M., Ferlay, J., van Berge Henegouwen, M.I. and Soerjomataram, I. (2020) Global Burden of Oesophageal and Gastric Cancer by Histology and Subsite in 2018. Gut, 69, 1564-1571. [Google Scholar] [CrossRef] [PubMed]
[3] 张绍丽, 曹毛毛, 杨帆, 等. 上消化道癌前病变患者健康相关生活质量评价及影响因素研究[J]. 中国肿瘤, 2024, 33(9): 747-755.
[4] 杨闪闪, 娄彦妮, 贾立群. 舌苔形成机制的研究进展[J]. 中华中医药杂志, 2022, 37(10): 5857-5860.
[5] 李萌, 于靖文, 丁媛, 等. 慢性萎缩性胃炎患者舌象、脉象与胃镜象相关性分析[J]. 辽宁中医杂志, 2024, 51(5): 10-14.
[6] 陈中倩. 慢性萎缩性胃炎唇象、舌象、胃镜象辨证分布规律研究[D]: [硕士学位论文]. 济南: 山东中医药大学, 2017.
[7] 周明瀚, 刘旺华, 李花, 等. 原发性高血压阴虚阳亢证舌象客观化研究[J]. 中华中医药杂志, 2022, 37(6): 3401-3404.
[8] Jiang, T., Lu, Z., Hu, X., Zeng, L., Ma, X., Huang, J., et al. (2022) Deep Learning Multi-Label Tongue Image Analysis and Its Application in a Population Undergoing Routine Medical Checkup. Evidence-Based Complementary and Alternative Medicine, 2022, Article ID: 3384209. [Google Scholar] [CrossRef] [PubMed]
[9] 段梦遥, 王楚皓, 谈宇权, 等. 315例冠心病患者舌象特征客观化研究[J]. 中医杂志, 2024, 65(9): 921-927.
[10] Shi, Y., Guo, D., Chun, Y., Liu, J., Liu, L., Tu, L., et al. (2023) A Lung Cancer Risk Warning Model Based on Tongue Images. Frontiers in Physiology, 14, Article 1154294. [Google Scholar] [CrossRef] [PubMed]
[11] 范宝超, 黄旭晖, 谭为. 肿瘤舌象信息研究进展[J]. 世界科学技术-中医药现代化, 2020, 22(5): 1614-1618.
[12] Dosovitskiy, A., Beyer, L., Kolesnikov, A., et al. (2021) An Image Is Worth 16 × 16 Words: Transformers for Image Recognition at Scale. arXiv: 2010.11929.
[13] Mazurowski, M.A., Dong, H., Gu, H., Yang, J., Konz, N. and Zhang, Y. (2023) Segment Anything Model for Medical Image Analysis: An Experimental Study. Medical Image Analysis, 89, Article ID: 102918. [Google Scholar] [CrossRef] [PubMed]
[14] Chen, L.C., Papandreou, G., Schroff, F., et al. (2017) Rethinking Atrous Convolution for Semantic Image Segmentation. arXiv: 1706.05587.
[15] Tang, W., Gao, Y., Liu, L., Xia, T., He, L., Zhang, S., et al. (2020) An Automatic Recognition of Tooth-Marked Tongue Based on Tongue Region Detection and Tongue Landmark Detection via Deep Learning. IEEE Access, 8, 153470-153478. [Google Scholar] [CrossRef
[16] Yan, J., Cai, J., Xu, Z., Guo, R., Zhou, W., Yan, H., et al. (2023) Tongue Crack Recognition Using Segmentation Based Deep Learning. Scientific Reports, 13, Article No. 511. [Google Scholar] [CrossRef] [PubMed]
[17] Hu, J., Yan, Z. and Jiang, J. (2022) Classification of Fissured Tongue Images Using Deep Neural Networks. Technology and Health Care, 30, 271-283. [Google Scholar] [CrossRef] [PubMed]
[18] 卢宏涛, 张秦川. 深度卷积神经网络在计算机视觉中的应用研究综述[J]. 数据采集与处理, 2016, 31(1): 1-17.
[19] Lecun, Y., Bottou, L., Bengio, Y. and Haffner, P. (1998) Gradient-Based Learning Applied to Document Recognition. Proceedings of the IEEE, 86, 2278-2324. [Google Scholar] [CrossRef
[20] Krizhevsky, A., Sutskever, I. and Hinton, G.E. (2017) ImageNet Classification with Deep Convolutional Neural Networks. Communications of the ACM, 60, 84-90. [Google Scholar] [CrossRef
[21] Simonyan, K. and Zisserman, A. (2015) Very Deep Convolutional Networks for Large-Scale Image Recognition. arXiv: 1409.1556.
[22] Szegedy, C., Liu, W., Jia, Y., et al. (2014) Going Deeper with Convolutions. arXiv: 1409.4842.
[23] He, K., Zhang, X., Ren, S., et al. (2015) Deep Residual Learning for Image Recognition. arXiv: 1512.03385.
[24] Xie, S., Girshick, R., Dollár, P., et al. (2017) Aggregated Residual Transformations for Deep Neural Networks. arXiv: 1611.05431.
[25] DeVries, T. and Taylor, G.W. (2017) Improved Regularization of Convolutional Neural Networks with Cutout. arXiv: 1708.04552.
[26] Zhong, Z., Zheng, L., Kang, G., et al. (2017) Random Erasing Data Augmentation. arXiv: 1708.04896.
[27] Chawla, N.V., Bowyer, K.W., Hall, L.O. and Kegelmeyer, W.P. (2002) SMOTE: Synthetic Minority Over-Sampling Technique. Journal of Artificial Intelligence Research, 16, 321-357. [Google Scholar] [CrossRef
[28] Ling, C. and Sheng, V.S. (2008) Cost-Sensitive Learning and the Class Imbalance Problem. In: Sammut, C. and Webb, G.I., Eds., Encyclopedia of Machine Learning. https://link.springer.com/referencework/10.1007/978-0-387-30164-8 [Google Scholar] [CrossRef
[29] Qiao, X., Lu, C., Duan, M., Liu, Z., Liu, Y., Chen, W., et al. (2024) Intelligent Tongue Diagnosis Model for Gastrointestinal Diseases Based on Tongue Images. Biomedical Signal Processing and Control, 96, Article ID: 106643. [Google Scholar] [CrossRef
[30] Srivastava, N., Hinton, G., Krizhevsky, A., et al. (2014) Dropout: A Simple Way to Prevent Neural Networks from Overfitting. Journal of Machine Learning Research, 15, 1929-1958.
[31] Ioffe, S. and Szegedy, C. (2015) Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift. arXiv: 1502.03167.
[32] Prechelt, L. (2012) Early Stopping—But When? In: Montavon, G., Orr, G.B. and Müller, K.R., Eds., Neural Networks: Tricks of the Trade, Springer, 53-67. [Google Scholar] [CrossRef
[33] Ma, C., Zhang, P., Du, S., Li, Y. and Li, S. (2023) Construction of Tongue Image-Based Machine Learning Model for Screening Patients with Gastric Precancerous Lesions. Journal of Personalized Medicine, 13, Article 271. [Google Scholar] [CrossRef] [PubMed]
[34] 顾晓, 邢莹莹. 幽门螺杆菌CagA诱导胃部炎癌转化的研究进展[J]. 中国药科大学学报, 2025, 56(1): 132-138.
[35] 赫捷, 陈万青, 李兆申, 等. 中国胃癌筛查与早诊早治指南(2022, 北京) [J]. 中华肿瘤杂志, 2022, 44(7): 634-666.
[36] Yuan, L., Yang, L., Zhang, S., Xu, Z., Qin, J., Shi, Y., et al. (2023) Development of a Tongue Image-Based Machine Learning Tool for the Diagnosis of Gastric Cancer: A Prospective Multicentre Clinical Cohort Study. eClinicalMedicine, 57, Article ID: 101834. [Google Scholar] [CrossRef] [PubMed]
[37] Sun, X., Huang, L., Qu, L., Chen, C., Zeng, X., Zhou, Z., et al. (2025) Development of a Tongue Image-Based Machine Learning Tool for the Diagnosis of Colorectal Cancer: A Prospective Multicentre Clinical Cohort Study. IEEE Journal of Biomedical and Health Informatics. [Google Scholar] [CrossRef] [PubMed]
[38] 张景慧, 王娟, 赵玉洁. 基于机器学习的胃肠道疾病舌诊模型构建[J]. 山东大学学报(医学版), 2024, 62(1): 38-47, 70.
[39] 黄丽, 李艳霞, 吴练练, 等. 基于深度学习的良恶性胃溃疡人工智能辅助诊断系统研究[J]. 中华消化内镜杂志, 2020, 37(7): 476-480.
[40] 徐伟超, 李博林, 许亚培, 等. 基于快速区域卷积神经网络萎缩性胃炎-胃癌胃镜图像自动识别模型的建立及临床测试[J]. 世界科学技术-中医药现代化, 2021, 23(9): 3274-3280.