代谢影响自主神经对肿瘤的发生与发展的影响

The Influence of Metabolism on the Autonomic Nerves on Tumor Occurrence and Development

摘要: 肿瘤疾病的发生机制十分复杂，起病十分隐晦，难以精准诊断，这导致了肿瘤疾病的发病率与死亡率始终居高不下，是当前威胁全球人类生命健康的重大公共卫生问题之一。近年来随着分子生物学与神经医学研究的不断深入，越来越多研究证据表明，肿瘤的发生发展不仅与肿瘤细胞自身的增殖、突变相关，还和肿瘤微环境中的神经调控、代谢重编程过程存在密切关联。其中，机体代谢状态的改变会直接影响自主神经系统的功能活性与信号传导，进而通过一系列复杂的分子通路，调控肿瘤细胞的增殖、侵袭、转移以及免疫逃逸过程，对肿瘤的发生发展起到关键的推动作用。本综述将围绕代谢、自主神经系统与肿瘤三者的交互关系展开梳理，系统总结代谢对自主神经调控肿瘤进程的影响机制，以期为肿瘤的临床诊断与新型治疗方案开发提供新的理论参考。

Abstract: The pathogenesis of tumor diseases is very complex, the onset is very obscure, and it is difficult to accurately diagnose, which leads to the high incidence and mortality of tumor diseases. It is one of the major public health problems that threaten human life and health worldwide. In recent years, with the deepening of molecular biology and neuromedicine research, more and more research evidence shows that the occurrence and development of tumors are not only related to the proliferation and mutation of tumor cells themselves, but also closely related to the neural regulation and metabolic reprogramming process in the tumor microenvironment. Among them, the changes in the metabolic state of the body will directly affect the functional activity and signal transduction of the autonomic nervous system, and then regulate the proliferation, invasion, metastasis and immune escape process of tumor cells through a series of complex molecular pathways, which play a key role in promoting the occurrence and development of tumors. This review will focus on the interaction between metabolism, the autonomic nervous system and tumor, and systematically summarize the mechanism of metabolism on the regulation of tumor progression by the autonomic nervous system, in order to provide a new theoretical reference for the clinical diagnosis and new treatment of tumors.