基于“和解少阳”理论探讨小柴胡颗粒联合 泮托拉唑治疗胃食管反流病的疗效观察

Observation on the Efficacy of Xiaochaihu Granules Combined with Pantoprazole in the Treatment of Gastroesophageal Reflux Disease Based on the Theory of “Relieving Shaoyang Disorder”

摘要: 目的：基于“和解少阳”理论观察小柴胡颗粒联合泮托拉唑治疗胃食管反流病的临床疗效。方法：选取2023年09月至2025年09月于天柱县中医医院治疗64例胃食管反流病患者，按照随机数字法分为2组，对照组32例以泮托拉唑口服，治疗组32例在对照组基础上予小柴胡颗粒口服，2组疗程均为12周。对比两组患者治疗前后的中医证候积分、食管黏膜损伤评分及临床疗效。结果：治疗12周后，两组中医证候积分、食管黏膜损伤评分均改善，且治疗组优于对照组，差异有统计学意义(P < 0.05)。结论：小柴胡颗粒联合泮托拉唑可有效缓解胃食管反流病患者的临床症状，减轻食管黏膜损伤，提高生活质量，以“和解少阳”立论的小柴胡颗粒符合胃食管反流病病机病证。

Abstract: Objective: To observe the clinical efficacy of Xiaochaihu Granules combined with pantoprazole in treating gastroesophageal reflux disease (GERD) based on the theory of “relieving shaoyang disorder”. Methods: A total of 64 GERD patients treated at Tianzhu County Hospital of Traditional Chinese Medicine from September 2023 to September 2025 were enrolled and randomly divided into two groups using a random number method. The control group (n = 32) received oral pantoprazole, while the treatment group (n = 32) received oral Xiaochaihu Granules in addition to pantoprazole. Both groups underwent a 12-week treatment course. The Traditional Chinese Medicine syndrome scores, esophageal mucosal injury scores, and clinical efficacy were compared before and after treatment. Results: After 12 weeks of treatment, both groups showed improvement in Traditional Chinese Medicine syndrome scores and esophageal mucosal injury scores, with the treatment group demonstrating superior outcomes compared to the control group (P < 0.05). Conclusion: Xiaochaihu Granules combined with pantoprazole can effectively alleviate clinical symptoms of GERD patients, reduce esophageal mucosal injury, and improve quality of life. The therapeutic principle of “relieving shaoyang disorder” in Xiaochaihu Granules aligns with the pathogenesis and clinical manifestations of GERD.