系统性红斑狼疮发病机制研究进展
Research Progress on the Pathogenesis of Systemic Lupus Erythematosus
DOI: 10.12677/acm.2026.1651988, PDF,    科研立项经费支持
作者: 王鸿儒, 邓冰冰：暨南大学附属第一医院皮肤科，广东 广州；东莞市滨海湾中心医院皮肤科，东莞市皮肤肿瘤及免疫炎症性皮肤病研究重点实验室，广东 东莞；路庆丽*：东莞市滨海湾中心医院皮肤科，东莞市皮肤肿瘤及免疫炎症性皮肤病研究重点实验室，广东 东莞；暨南大学第一临床医学院，广东 广州
关键词: 系统性红斑狼疮；发病机制；免疫系统；Systemic Lupus Erythematosus； Pathogenesis； Immune System
摘要: 作为一种与严重器官损伤相关的异质性自身免疫性疾病，在系统性红斑狼疮(Systemic lupus erythematosus, SLE)中，皮肤、关节、肾脏、血液、心血管系统和中枢神经系统都可能受累，每个患者都表现出不同的疾病模式，给社会及个人造成了经济负担。然而SLE的确切机制仍有待阐明，最新研究表明SLE与基因、环境因素及免疫系统之间的相互作用有关。目前比较清晰的发病机制仍是固有免疫系统和获得性免疫系统的异常。但近年来表观遗传修饰、肠道菌群也可能与SLE的发病息息相关。为更深入了解该复杂疾病的发病机制，本文就其相关的研究进展进行综述。
Abstract: As a heterogeneous autoimmune disease associated with severe organ damage, systemic lupus erythematosus (SLE) can involve the skin, joints, kidneys, cardiovascular system, and central nervous system, with each patient exhibiting a different pattern of disease, imposing an economic burden on society and individuals. However, the exact mechanisms of SLE remain to be elucidated. Recent studies suggest that SLE is related to the interaction between genes, environmental factors, and the immune system. The current clearer mechanisms of pathogenesis involve abnormalities in the innate immune system and the acquired immune system. In recent years, epigenetic modifications and gut microbiota may also be closely related to the onset of SLE. To gain a deeper understanding of the pathogenesis of this complex disease, this article reviews the relevant research progress.
文章引用：王鸿儒, 邓冰冰, 路庆丽. 系统性红斑狼疮发病机制研究进展[J]. 临床医学进展, 2026, 16(5): 1843-1852. https://doi.org/10.12677/acm.2026.1651988

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