ABCD1、CD99、β-Catenin在胰腺实性 假乳头状肿瘤中的诊断价值

Diagnostic Value of ABCD1, CD99 and β-Catenin in Solid Pseudopapillary Neoplasm of the Pancreas

摘要: 目的：探讨ABCD1、CD99、β-catenin在胰腺实性假乳头状肿瘤中的诊断及鉴别诊断价值。方法：收集已明确诊断的胰腺肿瘤170例，其中94例pSPN、69例pNEN、7例pACC，回顾性分析临床病理资料，并运用免疫组织化学方法检测ABCD1、β-catenin、CD99在3种肿瘤中的表达。结果：ABCD1在pSPN中阳性率100% (94/94)，在pNEN中阳性率4.3% (3/69)，在pACC中全部阴性(0/7)，ABCD1在pSPN中的敏感性100%；特异性96.9%；CD99在pSPN中阳性率97.9% (92/94)，在pNEN中阳性率15.9% (11/69)，在pACC中阳性率14.3% (1/7)，CD99在pSPN中的敏感性97.9%；特异性88.2%；β-catenin在pSPN中阳性率95.7% (90/94)，在pNEN中阳性率7.2% (4/69)，在pACC中阳性率14.3% (1/7)，β-catenin在pSPN中的敏感性及特异性分别为：95.7%；94.7%。因pACC样本量仅7例，其鉴别诊断价值仅为初步结果。结论：ABCD1、β-catenin、CD99的表达有助于pSPN的诊断与鉴别诊断，其中ABCD1较其它两种抗体有更好的敏感性及特异性。本研究关于pACC的鉴别结论需扩大样本量进一步验证。

Abstract: Objective: To explore the value of combined use of ABCD1, CD99, and β-catenin in the diagnosis and differential diagnosis of solid pseudopapillary neoplasm of the pancreas (pSPN). Methods: A total of 170 cases of pancreatic tumors with definite diagnoses were collected, including 94 cases of pSPN, 69 cases of neuroendocrine neoplasm of the pancreas(pNEN), and 7 cases of acinar cell carcinoma of the pancreas (pACC). The clinicopathological data were analyzed retrospectively, and the expressions of ABCD1, β-catenin, and CD99 in all cases were detected by immunohistochemical method. Results: The positive rate of ABCD1 in pSPN is 100% (94/94), in pNEN is 4.3% (3/69), and in pACC is completely negative (0/7). The sensitivity and specificity of ABCD1 in pSPN are 100% and 96.9% respectively. The positive rate of CD99 in pSPN is 97.9% (92/94), in pNEN is 15.9% (11/69), and in pACC is 14.3% (1/7). The sensitivity and specificity of CD99 in pSPN are 97.9% and 88.2% respectively. The positive rate of β-catenin in pSPN is 95.7% (90/94), in pNEN is 7.2% (4/69), and in pACC is 14.3% (1/7). The sensitivity and specificity of β-catenin in pSPN are 95.7% and 94.7% respectively. Since only 7 cases of pACC were included, its value in differential diagnosis represents a preliminary finding. Conclusion: The expression of ABCD1, β-catenin and CD99 is helpful for the diagnosis and differential diagnosis of pSPN, among which ABCD1 has better sensitivity and specificity than the other two antibodies. The conclusions regarding the differential diagnosis of pACC in this study need to be further verified with an expanded sample size.