纳米载药系统在消除口腔致龋生物膜的应用 进展
Advances in Nano-Drug Delivery Systems for the Eradication of Oral Cariogenic Biofilms
DOI: 10.12677/acm.2026.1652004, PDF,   
作者: 张鑫怡, 邓 洋*：重庆医科大学附属口腔医院，重庆；口腔疾病研究重庆市重点实验室，重庆
关键词: 纳米载药；生物膜；龋病；Nano-Drug Delivery； Biofilm； Dental Caries
摘要: 龋病是口腔内常见的非传染性疾病，随着其不断发展会严重危害人类的身心健康。龋病的主要致病因素之一是以变异链球菌为主的致龋微生物之间的相互作用，使用抗菌药物消除致龋微生物或妨碍其增殖作用成为防治龋病的一大热点。常规给药体系用于口腔龋病存在明显不足，随着纳米载药系统逐渐步入人们视线，不同的纳米给药体系被研究运用于此。其中，聚合物纳米颗粒、胶束、液晶纳米系统、脂质体纳米颗粒和无机纳米颗粒因其独特的抗菌和黏附特性，在消除口腔致龋生物膜方面显示出巨大的潜力。因此，本文综述了可用于消除口腔内致龋生物膜的常见纳米载药体系。
Abstract: Dental caries is a common non-communicable disease in the oral cavity, and its progression can severely impact human physical and mental health. One of the primary etiological factors of dental caries is the interaction among cariogenic microorganisms, predominantly Streptococcus mutans. The use of antimicrobial agents to eliminate cariogenic microorganisms or inhibit their proliferation has emerged as a major focus in caries prevention and treatment. Conventional drug delivery systems exhibit significant limitations when applied to oral caries management. With the gradual emergence of nanodrug delivery systems into the research spotlight, various nanoscale delivery platforms have been explored for this application. Among these, polymeric nanoparticles, micelles, liquid crystalline nanosystems, liposomal nanoparticles, and inorganic nanoparticles have demonstrated considerable potential for eliminating oral cariogenic biofilms due to their unique antimicrobial and adhesive properties. Therefore, this review summarizes the common nano-drug delivery systems applicable for the elimination of oral cariogenic biofilms.
文章引用：张鑫怡, 邓洋. 纳米载药系统在消除口腔致龋生物膜的应用 进展[J]. 临床医学进展, 2026, 16(5): 1981-1988. https://doi.org/10.12677/acm.2026.1652004

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