代谢综合征与子宫内膜癌的相关性及分子机制研究进展

Metabolic Syndrome and Endometrial Cancer: Research Progress on Correlation and Molecular Mechanisms

摘要: 子宫内膜癌(endometrial cancer, EC)是起源于子宫内膜的上皮性恶性肿瘤，是女性生殖系统三大恶性肿瘤之一，严重威胁女性生殖健康与生命安全。代谢综合征(metabolic syndrome, MS)是一组以高血糖、中心性肥胖、高血压及血脂异常等合并发病的临床综合征。近年来，大量临床与基础研究证实，代谢综合征与多种恶性肿瘤的发生发展密切相关，其中与子宫内膜癌的关联尤为突出。本文系统综述近年来代谢综合征相关因素和机制在子宫内膜癌发病中的作用和研究进展，旨在为子宫内膜癌的早期筛查、预防以及诊治提供新的靶点及科学理论依据。

Abstract: Endometrial cancer (EC) is an epithelial malignancy originating from the endometrium and is one of the three major malignancies of the female reproductive system, posing a serious threat to women’s reproductive health and life safety. Metabolic syndrome (MS) is a clinical syndrome characterized by a combination of hyperglycemia, central obesity, hypertension, and dyslipidemia. In recent years, a large number of clinical and basic studies have confirmed that metabolic syndrome is closely associated with the development and progression of various malignancies, with a particularly prominent link to endometrial cancer. This article systematically reviews recent research progress on the role and mechanisms of metabolic syndrome-related factors in the pathogenesis of endometrial cancer, aiming to provide new targets and a scientific theoretical basis for early screening, prevention, diagnosis, and treatment of endometrial cancer.