口疮散联合饮食指导治疗复发性口腔溃疡的临床研究

A Clinical Study on the Treatment of Recurrent Oral Ulcers Using a Kouchuang Powder Combined with Dietary Guidance

摘要: 目的：探究口疮散联合饮食指导在复发性口腔溃疡(ROU)临床治疗中的应用效果及安全性。方法：选取2023年4月~2025年3月本院收治的80例复发性口腔溃疡患者作为研究对象，采用随机数字表法将其分为研究组与对照组，各40例。对照组给予葡萄糖酸氯己定含漱液治疗，研究组另给予口疮散并结合饮食指导治疗。两组均以7天为一疗程，治疗后每月随访1次，观察至治疗结束后3个月。本课题分别观察治疗前、治疗后一周的各项指标，并随访治疗后3个月的复发情况。同时记录在两组治疗方案中出现的不良反应情况并进行评价。比较两组临床疗效、平均溃疡期、治疗后疼痛指数、复发情况及不良反应。结果：研究组疼痛指数低于对照组(P < 0.05)；研究组平均溃疡期短于对照组(P < 0.05)；研究组总有效率高于对照组(P < 0.05)；随访3个月，研究组复发率低于对照组(P < 0.05)；两组不良反应发生率比较，差异无统计学意义(P > 0.05)。结论：口疮散结合饮食指导治疗复发性口腔溃疡效果显著，可减轻疼痛、缩短溃疡愈合时间、降低复发率，且安全性良好。

Abstract: Objective: To explore the application effect and safety of Kouchuang Powder combined with dietary guidance in the clinical treatment of recurrent oral ulcer (ROU). Methods: A total of 80 patients with recurrent oral ulcer admitted to our hospital from April 2023 to March 2025 were selected as research subjects and divided into a study group and a control group using a random number table method, with 40 cases in each group. The control group was treated with chlorhexidine gluconate mouthwash, while the study group was additionally given Kouchuang Powder combined with dietary guidance. Both groups received a 7-day treatment course, followed by monthly follow-up visits for 3 months after treatment completion. Various indicators were observed before treatment and one week after treatment, and recurrence was recorded at the 3-month follow-up. Adverse reactions in both treatment regimens were documented and evaluated. Clinical efficacy, mean ulcer duration, post-treatment pain index, recurrence rate, and adverse reactions were compared between the two groups. Results: The pain index of the study group was lower than that of the control group (P < 0.05); the mean ulcer duration of the study group was shorter than that of the control group (P < 0.05); the total effective rate of the study group was higher than that of the control group (P < 0.05); at the 3-month follow-up, the recurrence rate of the study group was lower than that of the control group (P < 0.05); there was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: Kouchuang Powder combined with dietary guidance has a significant therapeutic effect on recurrent oral ulcer, which can relieve pain, shorten ulcer healing time, reduce the recurrence rate, and shows favorable safety.