中药防治内质网应激治疗糖尿病周围神经病变的研究进展
Research Progress of Traditional Chinese Medicine in Preventing and Treating Diabetic Peripheral Neuropathy by Regulating Endoplasmic Reticulum Stress
DOI: 10.12677/tcm.2026.155284, PDF,   
作者: 耿 越：黑龙江中医药大学第一临床医学院，黑龙江 哈尔滨；马 建*：黑龙江中医药大学附属第一医院内分泌科，黑龙江 哈尔滨
关键词: 糖尿病周围神经病变；内质网应激；未折叠蛋白反应；中药；雪旺细胞；Diabetic Peripheral Neuropathy； Endoplasmic Reticulum Stress； Unfolded Protein Response； Traditional Chinese Medicine； Schwann Cells
摘要: 糖尿病周围神经病变(DPN)是糖尿病常见并发症，发病机制复杂，尚缺乏有效逆转药物。内质网应激(ERS)及未折叠蛋白反应(UPR)在高糖诱导的雪旺细胞损伤及神经细胞凋亡中发挥关键作用。中药从“气虚血瘀”“络脉痹阻”等病机入手，在调控ERS、保护周围神经方面具有多靶点优势。本文系统综述ERS-UPR信号通路在DPN发病中的作用机制，以及中药复方及活性单体通过调控上述通路治疗DPN的研究进展，以期为DPN的临床治疗提供理论参考。
Abstract: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus with complex pathogenesis and a lack of effective reversal drugs. Endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) play critical roles in high glucose‑induced Schwann cell injury and neuronal apoptosis. Traditional Chinese medicine (TCM), targeting the pathogenesis of “qi deficiency and blood stasis”, exhibits multi‑target advantages in regulating ERS and protecting peripheral nerves. This article systematically reviews the mechanisms of the ERS‑UPR signaling pathways in the pathogenesis of DPN, as well as the research progress of Chinese herbal formulas and active monomers in treating DPN by modulating these pathways, aiming to provide a theoretical reference for the clinical treatment of DPN.
文章引用：耿越, 马建. 中药防治内质网应激治疗糖尿病周围神经病变的研究进展[J]. 中医学, 2026, 15(5): 305-312. https://doi.org/10.12677/tcm.2026.155284

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