|
[1]
|
Zhou, J., Yang, Q., Zhao, S., Sun, L., Li, R., Wang, J., et al. (2025) Evolving Landscape of Colorectal Cancer: Global and Regional Burden, Risk Factor Dynamics, and Future Scenarios (the Global Burden of Disease 1990-2050). Ageing Research Reviews, 104, Article 102666. [Google Scholar] [CrossRef] [PubMed]
|
|
[2]
|
Wu, S., Zhang, Y., Lin, Z. and Wei, M. (2025) Global Burden of Colorectal Cancer in 2022 and Projections to 2050: Incidence and Mortality Estimates from GLOBOCAN. BMC Cancer, 25, Article No. 1770. [Google Scholar] [CrossRef]
|
|
[3]
|
Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
|
|
[4]
|
Zhang, Y., Song, K., Zhou, Y., Chen, Y., Cheng, X., Dai, M., et al. (2025) Accuracy and Long-Term Effectiveness of Established Screening Modalities and Strategies in Colorectal Cancer Screening: An Umbrella Review. International Journal of Cancer, 157, 126-138. [Google Scholar] [CrossRef] [PubMed]
|
|
[5]
|
Zhang, J.Z., Yang, M. and Wang, X.S. (2024) Epidemiology and Disease Burden of Colorectal Cancer in China, the United States, and Worldwide: A Comparative Analysis and Reflection. Chinese Journal of Colorectal Diseases (Electronic Edition), 13, 89-93.
|
|
[6]
|
Zhou, H., Wang, Y., Wang, F., Meng, R., Yu, Y., Han, S., et al. (2025) Assessing Cross-Country Inequalities in Global Burden of Gastrointestinal Cancers: Slope and Concentration Index Approach. Discover Oncology, 16, Article No. 41. [Google Scholar] [CrossRef] [PubMed]
|
|
[7]
|
Abreu Lopez, B.A., Pinto-Colmenarez, R., Caliwag, F.M.C., Ponce-Lujan, L., Fermin, M.D., Granillo Cortés, A.V., et al. (2024) Colorectal Cancer Screening and Management in Low-and Middle-Income Countries and High-Income Countries: A Narrative Review. Cureus, 16, e70933. [Google Scholar] [CrossRef] [PubMed]
|
|
[8]
|
Capuozzo, M., Picone, C., Sabbatino, F., Santorsola, M., Caraglia, F., Iervolino, D., et al. (2025) Genetic, Epidemiological, Clinical, and Therapeutic Trajectories in Colon and Rectal Cancers. Cancers, 17, Article No. 3438. [Google Scholar] [CrossRef]
|
|
[9]
|
Swain, J., Preeti, Mohanty, C., Bajoria, A.A., Patnaik, S., Ward Gahlawat, A., et al. (2025) Deciphering the Metabolic Landscape of Colorectal Cancer through the Lens of Ahr-Mediated Intestinal Inflammation. Discover Oncology, 16, Article No. 275. [Google Scholar] [CrossRef] [PubMed]
|
|
[10]
|
Yan, L., Shi, J. and Zhu, J. (2024) Cellular and Molecular Events in Colorectal Cancer: Biological Mechanisms, Cell Death Pathways, Drug Resistance and Signalling Network Interactions. Discover Oncology, 15, Article No. 294. [Google Scholar] [CrossRef] [PubMed]
|
|
[11]
|
中国家族遗传性肿瘤临床诊疗专家共识(2021年版)(4)——家族遗传性结直肠癌[J]. 中国肿瘤临床, 2022, 49(1): 1-5.
|
|
[12]
|
Silva, M.P.M.E., Sabbaga, J., Najman, H.L., Nascimento, C.D.C., Cotta-Pereira, R.L., Nicoluzzi, J.E.L., et al. (2024) From Oncologist to Surgeon-Genetics in Colorectal Metastasis for Surgeons. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), 37, e1689. [Google Scholar] [CrossRef] [PubMed]
|
|
[13]
|
Møller, P., Ahadova, A., Kloor, M., Seppälä, T.T., Burn, J., Haupt, S., et al. (2025) Colorectal Carcinogenesis in the Lynch Syndromes and Familial Adenomatous Polyposis: Trigger Events and Downstream Consequences. Hereditary Cancer in Clinical Practice, 23, Article No. 3. [Google Scholar] [CrossRef] [PubMed]
|
|
[14]
|
Keum, N. and Giovannucci, E. (2019) Global Burden of Colorectal Cancer: Emerging Trends, Risk Factors and Prevention Strategies. Nature Reviews Gastroenterology & Hepatology, 16, 713-732. [Google Scholar] [CrossRef] [PubMed]
|
|
[15]
|
Akhondi, H., Kalteh, E.A. and Lotfi, M.H. (2025) Common Risk Factors in Gastrointestinal Cancers: A Narrative Review. Medical Principles and Practice, 34, 509-526. [Google Scholar] [CrossRef] [PubMed]
|
|
[16]
|
Molla, M.D., Symonds, E.L., Winter, J.M., Cock, C. and Wassie, M.M. (2025) Association between Metabolic Obesity Phenotypes and Risk of Colorectal Neoplasia in a South Australian Surveillance Colonoscopy Population. Preventive Medicine Reports, 61, Article 103360. [Google Scholar] [CrossRef]
|
|
[17]
|
Alhosani, F., Alhamidi, R.S., Ilce, B.Y., Altaie, A.M., Ali, N., Hamad, A.M., et al. (2025) Transcriptome-Wide Analysis and Experimental Validation from FFPE Tissue Identifies Stage-Specific Gene Expression Profiles Differentiating Adenoma, Carcinoma In-Situ and Adenocarcinoma in Colorectal Cancer Progression. International Journal of Molecular Sciences, 26, Article 4194. [Google Scholar] [CrossRef] [PubMed]
|
|
[18]
|
Saskova, K., Landfors, M., Hlavac, V., Seborova, K., Bruha, J., Honkova, K., et al. (2026) Patterns of Chromosomal Instability and Epigenetic Alterations in Colorectal Cancer Progression: From High-Grade Dysplasia to Liver Metastases. Mutagenesis, 41, 156-166. [Google Scholar] [CrossRef]
|
|
[19]
|
Brunet Guasch, M., Feeley, N.A., Soriano, I., Thorn, S., Tomlinson, I.P.M., Nicholson, M.D., et al. (2025) Mathematical Modeling Quantifies “Just-Right” APC Inactivation for Colorectal Cancer Initiation. Cancer Research, 85, 5113-5127. [Google Scholar] [CrossRef]
|
|
[20]
|
Fodde, R., Smits, R. and Clevers, H. (2001) APC, Signal Transduction and Genetic Instability in Colorectal Cancer. Nature Reviews Cancer, 1, 55-67. [Google Scholar] [CrossRef] [PubMed]
|
|
[21]
|
Smith, G., Carey, F.A., Beattie, J., Wilkie, M.J.V., Lightfoot, T.J., Coxhead, J., et al. (2002) Mutations in APC, Kirsten-Ras, and P53—Alternative Genetic Pathways to Colorectal Cancer. Proceedings of the National Academy of Sciences, 99, 9433-9438. [Google Scholar] [CrossRef] [PubMed]
|
|
[22]
|
Afrăsânie, V.A., Marinca, M.V., Gafton, B., Rusu, A., Froicu, E.M., Sur, D., et al. (2025) Navigating Beyond the Surface—Prognostic Significance of KRAS, NRAS, BRAF, PIK3CA, and TP53 Mutations Examined by Exons. Frontiers in Oncology, 15, Article 1557609. [Google Scholar] [CrossRef] [PubMed]
|
|
[23]
|
Öner, M.G., Rokavec, M., Kaller, M., Bouznad, N., Horst, D., Kirchner, T., et al. (2018) Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice via Increasing Levels of IL6R and Pai1. Gastroenterology, 155, 1868-1882. [Google Scholar] [CrossRef] [PubMed]
|
|
[24]
|
Tang, Y. and Fan, Y. (2024) Combined KRAS and TP53 Mutation in Patients with Colorectal Cancer Enhance Chemoresistance to Promote Postoperative Recurrence and Metastasis. BMC Cancer, 24, Article No. 1155. [Google Scholar] [CrossRef] [PubMed]
|
|
[25]
|
Andac-Aktas, A.B. and Calibasi-Kocal, G. (2025) Immunological Landscape of Colorectal Cancer: Tumor Microenvironment, Cellular Players and Immunotherapeutic Opportunities. Frontiers in Molecular Biosciences, 12, Article 1687556. [Google Scholar] [CrossRef]
|
|
[26]
|
Chen, Y., Liang, Z. and Lai, M. (2024) Targeting the Devil: Strategies against Cancer-Associated Fibroblasts in Colorectal Cancer. Translational Research, 270, 81-93. [Google Scholar] [CrossRef] [PubMed]
|
|
[27]
|
SOURCE Database: LRRFIP1. Princeton University.
|
|
[28]
|
Nguyen, J.B. and Modis, Y. (2013) Crystal Structure of the Dimeric Coiled-Coil Domain of the Cytosolic Nucleic Acid Sensor LRRFIP1. Journal of Structural Biology, 181, 82-88. [Google Scholar] [CrossRef] [PubMed]
|
|
[29]
|
Liu, Y. and Yin, H.L. (1998) Identification of the Binding Partners for Flightless I, a Novel Protein Bridging the Leucine-Rich Repeat and the Gelsolin Superfamilies. Journal of Biological Chemistry, 273, 7920-7927. [Google Scholar] [CrossRef] [PubMed]
|
|
[30]
|
Zhang, Y., Wang, L., Wang, S., et al. (2014) Characterization of Gcf2/LRRFIP1 in Experimental Cerebral Ischemia and Its Role as a Modulator of Akt, mTOR and β-Catenin Signaling Pathways. Neuroscience, 268, 48-65.
|
|
[31]
|
Li, W.Q., Yu, H.Y., Li, Y.M., Wang, X., et al. (2014) Higher LRRFIP1 Expression in Glioblastoma Multiforme Is Associated with Better Response to Teniposide, a Type II Topoisomerase Inhibitor. Biochemical and Biophysical Research Communications, 446, 1261-1267. [Google Scholar] [CrossRef] [PubMed]
|
|
[32]
|
蒋祝昌, 佘军红. 富含亮氨酸重复序列的结合蛋白1的研究进展[J]. 国际生物医学工程杂志, 2012, 35(1): 61-64.
|
|
[33]
|
Zhou, L., Jiao, Y., Xue, J., et al. (2025) LRRFIP1 Inhibits White Adipocyte Differentiation by Suppressing the E2F6/C/EBPα Axis. Diabetes & Metabolism Journal.
|
|
[34]
|
Yang, P., An, H., Liu, X., Wen, M., Zheng, Y., Rui, Y., et al. (2010) The Cytosolic Nucleic Acid Sensor LRRFIP1 Mediates the Production of Type I Interferon via a β-Catenin-Dependent Pathway. Nature Immunology, 11, 487-494. [Google Scholar] [CrossRef] [PubMed]
|
|
[35]
|
Takimoto, M. (2019) Multidisciplinary Roles of LRRFIP1/GCF2 in Human Biological Systems and Diseases. Cells, 8, Article 108. [Google Scholar] [CrossRef] [PubMed]
|
|
[36]
|
Zhang, M., Li, H., Wang, T., et al. (2022) LRRFIP1 Enhances the Wnt/β-Catenin Pathway by Binding to DVLs in Myelodysplastic Syndrome. Chinese Journal of Hematology, 43, 410-417.
|
|
[37]
|
Wang, F., Li, Y., Zhou, X., et al. (2017) GCF2/LRRFIP1 Promotes Colorectal Cancer Metastasis and Liver Invasion through Integrin-Dependent RhoA Activation. Cancer Letters, 403, 91-101.
|
|
[38]
|
Li, Y., Li, W., Yang, Y., Lu, Y., He, C., Hu, G., et al. (2009) MicroRNA-21 Targets LRRFIP1 and Contributes to VM-26 Resistance in Glioblastoma Multiforme. Brain Research, 1286, 13-18. [Google Scholar] [CrossRef] [PubMed]
|
|
[39]
|
Maurice, M.M. and Angers, S. (2025) Mechanistic Insights into Wnt-β-Catenin Pathway Activation and Signal Transduction. Nature Reviews Molecular Cell Biology, 26, 371-388. [Google Scholar] [CrossRef] [PubMed]
|
|
[40]
|
Petersen, C.H., Mahmood, B., Badsted, C., Dahlby, T., Rasmussen, H.B., Hansen, M.B., et al. (2019) Possible Predisposition for Colorectal Carcinogenesis Due to Altered Gene Expressions in Normal Appearing Mucosa from Patients with Colorectal Neoplasia. BMC Cancer, 19, Article No. 643. [Google Scholar] [CrossRef] [PubMed]
|
|
[41]
|
Labbé, P., Faure, E., Lecointe, S., Le Scouarnec, S., Kyndt, F., Marrec, M., et al. (2017) The Alternatively Spliced LRRFIP1 Isoform-1 Is a Key Regulator of the Wnt/β-Catenin Transcription Pathway. Biochimica et Biophysica Acta—Molecular Cell Research, 1864, 1142-1152. [Google Scholar] [CrossRef] [PubMed]
|
|
[42]
|
Khezri, M.R., Jafari, R., Yousefi, K. and Zolbanin, N.M. (2022) The PI3K/AKT Signaling Pathway in Cancer: Molecular Mechanisms and Possible Therapeutic Interventions. Experimental and Molecular Pathology, 127, Article 104787. [Google Scholar] [CrossRef] [PubMed]
|
|
[43]
|
Han, B., Lin, X. and Hu, H. (2024) Regulation of PI3K Signaling in Cancer Metabolism and PI3K-Targeting Therapy. Translational Breast Cancer Research, 5, 33. [Google Scholar] [CrossRef] [PubMed]
|
|
[44]
|
Li, J., Tuo, D., Guo, G., Gao, Y. and Gan, J. (2024) The Clinical Significance and Oncogenic Function of LRRFIP1 in Pancreatic Cancer. Discover Oncology, 15, Article No. 123. [Google Scholar] [CrossRef] [PubMed]
|
|
[45]
|
Jere, S.W., Abrahamse, H. and Houreld, N.N. (2023) Interaction of the AKT and β-Catenin Signalling Pathways and the Influence of Photobiomodulation on Cellular Signalling Proteins in Diabetic Wound Healing. Journal of Biomedical Science, 30, Article No. 81. [Google Scholar] [CrossRef] [PubMed]
|
|
[46]
|
Jia, H., Bian, C. and Chang, Y. (2025) Exploring the Molecular Interactions between Ferroptosis and the Wnt/β-Catenin Signaling Pathway: Implications for Cancer and Disease Therapy. Critical Reviews in Oncology/Hematology, 210, Article 104674. [Google Scholar] [CrossRef] [PubMed]
|
|
[47]
|
Peixoto, A., Ferreira, D., Miranda, A., Relvas-Santos, M., Freitas, R., Veth, T.S., et al. (2025) Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells. iScience, 28, Article 111758. [Google Scholar] [CrossRef] [PubMed]
|
|
[48]
|
Bakhoum, S.F., Ngo, B., Laughney, A.M., Cavallo, J., Murphy, C.J., Ly, P., et al. (2018) Chromosomal Instability Drives Metastasis through a Cytosolic DNA Response. Nature, 553, 467-472. [Google Scholar] [CrossRef] [PubMed]
|
|
[49]
|
Shim, A., Chen, Y. and Maciejowski, J. (2025) Activation and Regulation of cGAS-Sting Signaling in Cancer Cells. Molecular Cell, 85, 3807-3822. [Google Scholar] [CrossRef]
|
|
[50]
|
Cho, M.G. and Gupta, G.P. (2025) Unveiling cGAS Mechanisms: Insights into DNA Damage and Immune Sensing in Cancer. DNA Repair, 153, Article 103878. [Google Scholar] [CrossRef] [PubMed]
|
|
[51]
|
Alim, L.F., Keane, C. and Souza-Fonseca-Guimaraes, F. (2024) Molecular Mechanisms of Tumour Necrosis Factor Signalling via TNF Receptor 1 and TNF Receptor 2 in the Tumour Microenvironment. Current Opinion in Immunology, 86, Article 102409. [Google Scholar] [CrossRef] [PubMed]
|
|
[52]
|
Tucci, G., Pacella, I., Pinzon Grimaldos, A., Rossi, A., Cammarata, I., Zagaglioni, M., et al. (2025) TNF Production or TNFR2 Expression Characterize Distinct States of Regulatory T Cells That Cooperate in Treg Expansion in Cancer and Chronic Inflammation. European Journal of Immunology, 55, e70062. [Google Scholar] [CrossRef]
|
|
[53]
|
Nam, Y.W., Shin, J., Kim, S., Hwang, C.H., Lee, C., Hwang, G., et al. (2024) EGFR Inhibits TNF-α-Mediated Pathway by Phosphorylating TNFR1 at Tyrosine 360 and 401. Cell Death & Differentiation, 31, 1318-1332. [Google Scholar] [CrossRef] [PubMed]
|
|
[54]
|
Suriano, A.R., Sanford, A.N., Kim, N., Oh, M., Kennedy, S., Henderson, M.J., et al. (2005) GCF2/LRRFIP1 Represses Tumor Necrosis Factor Alpha Expression. Molecular and Cellular Biology, 25, 9073-9081. [Google Scholar] [CrossRef] [PubMed]
|
|
[55]
|
Darnay, B.G. and Aggarwal, B.B. (1997) Early Events in TNF Signaling: A Story of Associations and Dissociations. Journal of Leukocyte Biology, 61, 559-566. [Google Scholar] [CrossRef] [PubMed]
|
|
[56]
|
Micheau, O. and Tschopp, J. (2003) Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes. Cell, 114, 181-190. [Google Scholar] [CrossRef] [PubMed]
|
|
[57]
|
Walczak, H. (2013) Death Receptor-Ligand Systems in Cancer, Cell Death, and Inflammation. Cold Spring Harbor Perspectives in Biology, 5, a008698. [Google Scholar] [CrossRef] [PubMed]
|
|
[58]
|
Douchi, D., Ohtsuka, H., Ariake, K., Masuda, K., Kawasaki, S., Kawaguchi, K., et al. (2015) Silencing of LRRFIP1 Reverses the Epithelial-Mesenchymal Transition via Inhibition of the Wnt/β-Catenin Signaling Pathway. Cancer Letters, 365, 132-140. [Google Scholar] [CrossRef] [PubMed]
|
|
[59]
|
Huang, Y., et al. (2021) Silencing of LRRFIP1 Enhances the Chemosensitivity of Pancreatic Cancer Cells to Gemcitabine via Activation of the JNK/c-Jun Signaling Pathway. Pancreatology.
|
|
[60]
|
基于生物信息学筛选骨关节炎中谷氨酰胺代谢关键基因LRRFIP1和MFSD11作为新型诊断标志物[J]. Scientific Reports, 2025.
|
|
[61]
|
Li, D., Wang, C., Qing, Y., Bao, X., Xu, J., Wang, X., et al. (2025) Potential Glutamine Metabolism-Related Biomarkers Were Identified in Osteoarthritis by Bioinformatics. Scientific Reports, 15, Article No. 45797. [Google Scholar] [CrossRef]
|
|
[62]
|
庹大云, 郭固楠, 张乐佳, 甘进锋, 李金平. GCF2/LRRFIP1的生物学功能及其在肿瘤中的作用[J]. 黑龙江科学, 2022, 13(6): 114-116.
|
|
[63]
|
Fong, K.S.K. and de Couet, H.G. (1999) Novel Proteins Interacting with the Leucine-Rich Repeat Domain of Human Flightless-I Identified by the Yeast Two-Hybrid System. Genomics, 58, 146-157. [Google Scholar] [CrossRef] [PubMed]
|
|
[64]
|
Oon, C.E., Anbazhagan, P. and Tan, C.T. (2025) Therapeutic Potential of Targeting Ubiquitin-Specific Proteases in Colorectal Cancer. Drug Discovery Today, 30, Article 104356. [Google Scholar] [CrossRef] [PubMed]
|