LRRFIP1调控结直肠癌细胞凋亡及相关信号 通路的研究进展
Progress in Research on LRRFIP1 Regulation of Colorectal Cancer Cell Apoptosis and Related Signaling Pathways
DOI: 10.12677/acm.2026.1652064, PDF,   
作者: 李恩德:哈尔滨医科大学附属第四医院病理科,黑龙江 哈尔滨
关键词: LRRFIP1TNFαFADD细胞凋亡结直肠癌LRRFIP1 TNFα FADD Cell Apoptosis Colorectal Cancer
摘要: 结直肠癌(CRC)是全球最常见的消化道恶性肿瘤之一,其发生发展与细胞凋亡密切相关。近年来有多项研究发现,亮氨酸富重复无飞相互作用蛋白1 (LRRFIP1)在多种癌症中呈现表达趋势,并能通过抑制死亡受体通路而削弱肿瘤细胞对凋亡诱导的敏感性。本文围绕“LRRFIP1–TNFα/FADD–细胞凋亡”这一轴心,旨在介绍LRRFIP1的分子特征、TNFα/FADD通路的凋亡调控机制、LRRFIP1-TNFα/FADD轴在CRC中的临床意义及靶向策略,并对未来研究方向进行展望,以期为CRC治疗提供新的理论依据。
Abstract: Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract worldwide, and its occurrence and development are closely related to cell apoptosis. In recent years, multiple studies have found that Leucine-Rich Repeat Flightless-Interacting Protein 1 (LRRFIP1) shows expression trends in various cancers and can weaken tumor cells’ sensitivity to apoptosis induction by inhibiting the death receptor pathway. This article centers on the “LRRFIP1 - TNFα/FADD - cell apoptosis” axis, aiming to introduce the molecular characteristics of LRRFIP1, the apoptosis regulatory mechanism of the TNFα/FADD pathway, the clinical significance and targeted strategies of the LRRFIP1-TNFα/FADD axis in CRC, and to project future research directions, intending to provide new theoretical basis for CRC treatment.
文章引用:李恩德. LRRFIP1调控结直肠癌细胞凋亡及相关信号 通路的研究进展[J]. 临床医学进展, 2026, 16(5): 2533-2541. https://doi.org/10.12677/acm.2026.1652064

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