肠道菌群–代谢物轴调控绝经后骨质疏松骨代谢失衡的机制研究进展
Research Progress on the Mechanism of Gut Microbiota-Metabolite Axis in Regulating Bone Metabolic Imbalance in Postmenopausal Osteoporosis
DOI: 10.12677/tcm.2026.155292, PDF,   
作者: 黃 笑：广西中医药大学研究生院，广西 南宁；广西中医药大学第一附属医院内分泌科，广西 南宁
关键词: 绝经后骨质疏松；肠道菌群；代谢物；肠–骨轴；骨代谢失衡；免疫调节；Postmenopausal Osteoporosis； Gut Microbiota； Metabolites； Gut-Bone Axis； Bone Metabolic Imbalance； Immunoregulation
摘要: 绝经后骨质疏松症是一种以骨量减少和骨微结构破坏为特征的全身性骨病，其核心在于骨代谢失衡。近年来，肠道菌群及其代谢产物构成的“肠道菌群–代谢物轴”在调控骨代谢中的作用日益凸显。本文综述了绝经后状态下肠道菌群紊乱的特征，重点探讨了短链脂肪酸、胆汁酸、色氨酸代谢物等肠道菌群衍生代谢物如何通过影响免疫系统、肠屏障功能及内分泌信号等途径，调控骨代谢失衡的分子机制，旨在阐明该轴在疾病发病中的作用，为发现新的诊断标志物和治疗靶点提供依据。
Abstract: Postmenopausal osteoporosis is a systemic bone disease characterized by reduced bone mass and deteriorated bone microarchitecture, with the core pathogenesis lying in imbalanced bone metabolism. In recent years, the “gut microbiota-metabolite axis” composed of gut microbiota and their metabolites has played an increasingly prominent role in regulating bone metabolism. This article reviews the characteristics of gut microbiota dysbiosis in the postmenopausal state, and focuses on the molecular mechanisms by which gut microbiota-derived metabolites such as short-chain fatty acids, bile acids, and tryptophan metabolites regulate bone metabolic imbalance via modulating the immune system, intestinal barrier function, and endocrine signaling. It aims to clarify the role of this axis in the disease pathogenesis and provide evidence for identifying novel diagnostic biomarkers and therapeutic targets.
文章引用：黃笑. 肠道菌群–代谢物轴调控绝经后骨质疏松骨代谢失衡的机制研究进展[J]. 中医学, 2026, 15(5): 363-369. https://doi.org/10.12677/tcm.2026.155292

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