从钟基因到临床节律紊乱：甲状腺疾病的昼夜节律新视角

From Clock Genes to Clinical Rhythm Disturbance: A Novel Circadian Rhythm Perspective on Thyroid Diseases

摘要: 近年来，生物钟基因在甲状腺疾病的发生和发展中发挥着日益显著的作用，逐渐引起了研究者们的广泛关注。昼夜节律的失调与甲状腺功能异常之间的紧密关联，不仅影响了患者的临床表现，还可能对治疗效果产生重要影响。现有研究表明，生物钟基因通过调节甲状腺激素的合成与分泌，影响甲状腺的生理功能及其代谢活动。然而，关于昼夜节律紊乱如何具体影响甲状腺功能的机制仍需进一步探索。此外，相关的临床研究也揭示了节律紊乱在甲状腺疾病治疗中的潜在影响。本文旨在综述钟基因在甲状腺疾病中的作用机制，探讨昼夜节律紊乱对甲状腺功能的影响，并分析相关临床研究成果，为未来的研究和治疗提供新的视角和方向。

Abstract: In recent years, circadian clock genes have played an increasingly significant role in the pathogenesis and progression of thyroid diseases, garnering widespread attention from researchers. The close association between circadian rhythm disruption and thyroid dysfunction not only influences the clinical manifestations of patients but may also substantially impact treatment efficacy. Current studies indicate that circadian clock genes modulate the physiological functions and metabolic activities of the thyroid gland by regulating the synthesis and secretion of thyroid hormones. However, the precise mechanisms through which circadian rhythm disturbances specifically affect thyroid function require further investigation. Additionally, relevant clinical research has revealed the potential implications of rhythm disruption in the treatment of thyroid disorders. This article aims to review the mechanisms of clock genes in thyroid diseases, explore the impact of circadian rhythm disruption on thyroid function, and analyze relevant clinical research findings, thereby providing new perspectives and directions for future research and treatment.